Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Matthew T O'Neill"'
Autor:
Michael J Coffey, Brad E Sleebs, Alessandro D Uboldi, Alexandra Garnham, Magdalena Franco, Nicole D Marino, Michael W Panas, David JP Ferguson, Marta Enciso, Matthew T O'Neill, Sash Lopaticki, Rebecca J Stewart, Grant Dewson, Gordon K Smyth, Brian J Smith, Seth L Masters, John C Boothroyd, Justin A Boddey, Christopher J Tonkin
Publikováno v:
eLife, Vol 4 (2015)
Infection by Toxoplasma gondii leads to massive changes to the host cell. Here, we identify a novel host cell effector export pathway that requires the Golgi-resident aspartyl protease 5 (ASP5). We demonstrate that ASP5 cleaves a highly constrained a
Externí odkaz:
https://doaj.org/article/87c2bb0c16e043169ac8333f604bb8e0
Autor:
Brad E Sleebs, Sash Lopaticki, Danushka S Marapana, Matthew T O'Neill, Pravin Rajasekaran, Michelle Gazdik, Svenja Günther, Lachlan W Whitehead, Kym N Lowes, Lea Barfod, Lars Hviid, Philip J Shaw, Anthony N Hodder, Brian J Smith, Alan F Cowman, Justin A Boddey
Publikováno v:
PLoS Biology, Vol 12, Iss 7, p e1001897 (2014)
The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a c
Externí odkaz:
https://doaj.org/article/577c998d81b343c095e557df66f4d3e1
Autor:
Lin Chen, Sash Lopaticki, David T Riglar, Chaitali Dekiwadia, Alex D Uboldi, Wai-Hong Tham, Matthew T O'Neill, Dave Richard, Jake Baum, Stuart A Ralph, Alan F Cowman
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002199 (2011)
Invasion of erythrocytes by Plasmodium falciparum involves a complex cascade of protein-protein interactions between parasite ligands and host receptors. The reticulocyte binding-like homologue (PfRh) protein family is involved in binding to and init
Externí odkaz:
https://doaj.org/article/d6f689f89410428290a6fcb764369739
Autor:
Melanie H. Dietrich, Mikha Gabriela, Kitsanapong Reaksudsan, Matthew W. A. Dixon, Li-Jin Chan, Amy Adair, Stephanie Trickey, Matthew T. O'Neill, Li Lynn Tan, Sash Lopaticki, Julie Healer, Sravya Keremane, Alan F. Cowman, Wai-Hong Tham
Publikováno v:
Biochemical Journal. 479:2529-2546
Transmission blocking interventions can stop malaria parasite transmission from mosquito to human by inhibiting parasite infection in mosquitos. One of the most advanced candidates for a malaria transmission blocking vaccine is Pfs230. Pfs230 is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8200538f8b6130bb0907cba51ccb49
https://doi.org/10.1042/bcj20220554
https://doi.org/10.1042/bcj20220554
Autor:
Charlie Jennison, Leonardo Lucantoni, Matthew T. O’Neill, Robyn McConville, Sara M. Erickson, Alan F. Cowman, Brad E. Sleebs, Vicky M. Avery, Justin A. Boddey
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3796-3806.e4 (2019)
Summary: Plasmodium falciparum gametocytes infect mosquitoes and are responsible for malaria transmission. New interventions that block transmission could accelerate malaria elimination. Gametocytes develop within erythrocytes and activate protein ex
Externí odkaz:
https://doaj.org/article/6043059db5da4594912be1fa76539835
Autor:
Annie S.P. Yang, Matthew T. O’Neill, Charlie Jennison, Sash Lopaticki, Cody C. Allison, Jennifer S. Armistead, Sara M. Erickson, Kelly L. Rogers, Andrew M. Ellisdon, James C. Whisstock, Rebecca E. Tweedell, Rhoel R. Dinglasan, Donna N. Douglas, Norman M. Kneteman, Justin A. Boddey
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3105-3116 (2017)
Malaria sporozoites are deposited into the skin by mosquitoes and infect hepatocytes. The molecular basis of how Plasmodium falciparum sporozoites migrate through host cells is poorly understood, and direct evidence of its importance in vivo is lacki
Externí odkaz:
https://doaj.org/article/c5e848ec4e7c450ba45671fa5262bdfc
Autor:
Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan W. J. Steel, Cindy Evelyn, Matthew T. O’Neill, Niccolay Madiedo Soler, Nichollas E. Scott, Kelly L. Rogers, Ethan D. Goddard-Borger, Justin A. Boddey
Publikováno v:
Nature Communications. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fcf30cf4b7c23ed6970b206096a6f39
https://doi.org/10.1038/s41467-022-32664-8
https://doi.org/10.1038/s41467-022-32664-8
Autor:
Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan W. J. Steel, Cindy Evelyn, Matthew T. O’Neill, Niccolay Madiedo Soler, Nichollas E. Scott, Kelly L. Rogers, Ethan D. Goddard-Borger, Justin A. Boddey
Publikováno v:
Nature Communications. 13
Tryptophan C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmodium falciparum expresses a DPY19 tryptophan C-mannosyltransferase in the endoplasmic reticulum and that DPY19-deficienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19956a36cfe26c06a3ff82ff5482aecb
https://doi.org/10.1038/s41467-022-32076-8
https://doi.org/10.1038/s41467-022-32076-8
Autor:
Melanie H Dietrich, Li-Jin Chan, Amy Adair, Coralie Boulet, Matthew T O'Neill, Li Lynn Tan, Sravya Keremane, Yee-Foong Mok, Alvin W Lo, Paul Gilson, Wai-Hong Tham
Publikováno v:
FEMS Microbes. 3
During the different stages of the Plasmodium life cycle, surface-associated proteins establish key interactions with the host and play critical roles in parasite survival. The 6-cysteine (6-cys) protein family is one of the most abundant surface ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::722795543a49c30772bb6f934c27d6a1
https://doi.org/10.1093/femsmc/xtac005
https://doi.org/10.1093/femsmc/xtac005
Autor:
Melanie H, Dietrich, Li-Jin, Chan, Amy, Adair, Coralie, Boulet, Matthew T, O'Neill, Li Lynn, Tan, Sravya, Keremane, Yee-Foong, Mok, Alvin W, Lo, Paul, Gilson, Wai-Hong, Tham
Publikováno v:
FEMS microbes. 3
During the different stages of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3277fe5158ab3ee3eaf046394aeab48b
https://pubmed.ncbi.nlm.nih.gov/35308105
https://pubmed.ncbi.nlm.nih.gov/35308105