Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Matthew T Duvernay"'
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57805 (2013)
The physiological and pathological functions of angiotensin II are largely mediated through activating the cell surface angiotensin II type 1 receptor (AT1R). However, the molecular mechanisms underlying the transport of newly synthesized AT1R from t
Externí odkaz:
https://doaj.org/article/886be236c7fe449eaa380a929e358ed1
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65528 (2013)
Protease activated receptor-4 (PAR4) is one of the thrombin receptors on human platelets and is a potential target for the management of thrombotic disorders. We sought to develop potent, selective, and novel PAR4 antagonists to test the role of PAR4
Externí odkaz:
https://doaj.org/article/f1fe95d2121446d78f56e84568d803ff
Autor:
Breanne H.Y. Gibson, Matthew T. Duvernay, Stephanie N. Moore‐Lotridge, Matthew J. Flick, Jonathan G. Schoenecker
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 4, Pp 469-480 (2020)
Abstract The musculoskeletal system is critical for movement and the protection of organs. In addition to abrupt injuries, daily physical demands inflict minor injuries, necessitating a coordinated process of repair referred to as the acute‐phase r
Externí odkaz:
https://doaj.org/article/ef606f45d3c84023a06b0b642dcad098
Autor:
Rachel A. Rigg, Laura D. Healy, Tiffany T. Chu, Anh T. P. Ngo, Annachiara Mitrugno, Jevgenia Zilberman-Rudenko, Joseph E. Aslan, Monica T. Hinds, Lisa Dirling Vecchiarelli, Terry K. Morgan, András Gruber, Kayla J. Temple, Craig W. Lindsley, Matthew T. Duvernay, Heidi E. Hamm, Owen J. T. McCarty
Publikováno v:
Platelets, Vol 30, Iss 1, Pp 126-135 (2019)
Human platelets express two protease-activated receptors (PARs), PAR1 (F2R) and PAR4 (F2RL3), which are activated by a number of serine proteases that are generated during pathological events and cause platelet activation. Recent interest has focused
Externí odkaz:
https://doaj.org/article/6960b5c705204591a63ac3d50fe5f52c
Autor:
Rebecca S. Cook, Dana M. Brantley-Sieders, David L. Elion, Jill M. Pulley, Meghan M. Joly, Robert R. Lavieri, Heidi Hamm, Jae G. Maeng, Matthew T. Duvernay, Wendy E. Bendeman, Bushra Rahman, Donna J. Hicks, Thomas A. Werfel
Although new drug discoveries are revolutionizing cancer treatments, repurposing existing drugs would accelerate the timeline and lower the cost for bringing treatments to cancer patients. Our goal was to repurpose CPI211, a potent and selective anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554902981c1ddb8ee844d3b98442fefa
https://doi.org/10.1158/1535-7163.c.6542767
https://doi.org/10.1158/1535-7163.c.6542767
Autor:
Rebecca S. Cook, Dana M. Brantley-Sieders, David L. Elion, Jill M. Pulley, Meghan M. Joly, Robert R. Lavieri, Heidi Hamm, Jae G. Maeng, Matthew T. Duvernay, Wendy E. Bendeman, Bushra Rahman, Donna J. Hicks, Thomas A. Werfel
Flow chart depicting the decision making steps towards selecting TBXA2R as a potential therapeutic target for drug repurposing of CPI211.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2fc2cb86334453a863d17dd9016ea5
https://doi.org/10.1158/1535-7163.22520773
https://doi.org/10.1158/1535-7163.22520773
Autor:
Rebecca S. Cook, Dana M. Brantley-Sieders, David L. Elion, Jill M. Pulley, Meghan M. Joly, Robert R. Lavieri, Heidi Hamm, Jae G. Maeng, Matthew T. Duvernay, Wendy E. Bendeman, Bushra Rahman, Donna J. Hicks, Thomas A. Werfel
Supplemental Table S1. Kaplan-Meier analysis of clinical cancer expression datasets (RNA-Seq) to assess the relationship between disease free patient survival and TBXA2R expression levels, as determined using Kmplot.com software, using the software-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013796120427f7f909528763e42c11cd
https://doi.org/10.1158/1535-7163.22520770.v1
https://doi.org/10.1158/1535-7163.22520770.v1
Autor:
Breanne H. Y. Gibson, Matthew T. Duvernay, Lydia J. McKeithan, Teresa A. Benvenuti, Tracy A. Warhoover, Jeffrey E. Martus, Gregory A. Mencio, Brian R. Emerson, Stephanie N. Moore-Lotridge, Alexandra J. Borst, Jonathan G. Schoenecker
Publikováno v:
Spine Deform
PURPOSE: Posterior spinal fusion (PSF) activates the fibrinolytic protease plasmin, which is implicated in blood loss and transfusion. While antifibrinolytic drugs have improved blood loss and reduced transfusion, variable blood loss has been observe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0348c803ad6d2f291a015c603dc0ff5a
https://europepmc.org/articles/PMC9891390/
https://europepmc.org/articles/PMC9891390/
Autor:
Stephanie N. Moore-Lotridge, Matthew J. Flick, Jonathan G. Schoenecker, Matthew T. Duvernay, Breanne H.Y. Gibson
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 4, Pp 469-480 (2020)
Research and Practice in Thrombosis and Haemostasis
Research and Practice in Thrombosis and Haemostasis
The musculoskeletal system is critical for movement and the protection of organs. In addition to abrupt injuries, daily physical demands inflict minor injuries, necessitating a coordinated process of repair referred to as the acute‐phase response (
Autor:
Fumie Nakashima, Claus Schneider, Juan Antonio Giménez-Bastida, Ezekiel O. Iwalewa, Matthew T. Duvernay, Abdul-Musawwir Alli-Oluwafuyi, Sai Han Presley, Paula B. Luis
Publikováno v:
Biochimie
Curcumin shows antiglycemic effects in animals. Curcumin is chemically unstable at physiological pH, and its oxidative degradation products were shown to contribute to its anti-inflammatory effects. Since the degradation products may also contribute