Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Matthew T, Harper"'
Autor:
Joanna-Marie Howes, Matthew T. Harper
Publikováno v:
Platelets, Vol 35, Iss 1 (2024)
AbstractSmall molecule drugs play a major role in the study of human platelets. Effective action of a drug requires it to bind to one or more targets within the platelet (target engagement). However, although in vitro assays with isolated proteins ca
Externí odkaz:
https://doaj.org/article/9aade0f0cb9a4384bad97a096502b8f7
Autor:
Venkat M. K. Vadlamani, Kavinda K. J. Gunasinghe, Xavier W. Chee, Taufiq Rahman, Matthew T. Harper
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract CD39 (ectonucleoside triphosphate diphosphohydrolase-1; ENTPD1) metabolizes extracellular ATP and ADP to AMP. AMP is subsequently metabolized by CD79 to adenosine. CD39 activity is therefore a key regulator of purinergic signalling in cancer
Externí odkaz:
https://doaj.org/article/0581af87244d40ae89108dfbb7344a87
Publikováno v:
Platelets, Vol 33, Iss 7, Pp 1090-1095 (2022)
Thrombin is a potent platelet activator, acting through proteinase-activated receptors −1 and −4 (PAR1 and PAR4). Of these, PAR-1 is activated more rapidly and by lower thrombin concentrations. Consequently, PAR-1 has been extensively investigate
Externí odkaz:
https://doaj.org/article/28e019c8c241410d81c7994c80d91efb
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Inflammatory diseases are often characterised by excessive neutrophil infiltration from the blood stream to the site of inflammation, which damages healthy tissue and prevents resolution of inflammation. Development of anti-inflammatory drug
Externí odkaz:
https://doaj.org/article/6d2a5339f846494bb9dd0e2fd3029ed2
Publikováno v:
Platelets, Vol 32, Iss 7, Pp 855-862 (2021)
Platelets are the major cellular contributor to arterial thrombosis. However, activated platelets form two distinct subpopulations during thrombosis. Pro-aggregatory platelets aggregate to form the main body of the thrombus. In contrast, procoagulant
Externí odkaz:
https://doaj.org/article/cce5abcaf42947278bb922cd8ea642bd
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Arterial thrombosis triggers myocardial infarction and is a leading cause of death worldwide. Procoagulant platelets, a subpopulation of activated platelets that expose phosphatidylserine (PS), promote coagulation and occlusive thrombosis. P
Externí odkaz:
https://doaj.org/article/a61c572fb7214bba92742c82d9ed3aec
Autor:
Nima Abbasian, Matthew T. Harper
Publikováno v:
Platelets, Vol 32, Iss 7, Pp 992-994 (2021)
Platelet-derived extracellular polyphosphate (PolyP) is a major mediator of thrombosis. PolyP is a linear chain of inorganic phosphate (Pi) and is stored in platelet dense granules. Pi enters cells from the extracellular fluid through phosphate trans
Externí odkaz:
https://doaj.org/article/ac170e70031a49608bb886790f23be67
Autor:
Hao Wei, Matthew T. Harper
Publikováno v:
Platelets, Vol 32, Iss 1, Pp 105-112 (2021)
Platelet lifespan is regulated by intrinsic apoptosis. Platelet apoptosis can be triggered by BH3 mimetics that inhibit the pro-survival Bcl-2 family protein, Bcl-xL. Here, we investigated several small molecules that are reported to act as BH3 mimet
Externí odkaz:
https://doaj.org/article/0309b57345474e64b0a379648063f182
Publikováno v:
Platelets, Vol 32, Iss 5, Pp 579-581 (2021)
Externí odkaz:
https://doaj.org/article/6ab7fd32e072483c93d5ecce813a8dae
Publikováno v:
Platelets, Vol 31, Iss 7, Pp 964-967 (2020)
Externí odkaz:
https://doaj.org/article/c0bee1d509fd4a44984c1e0b8d36e9b0