High-Throughput Screening Platforms in the Discovery of Novel Drugs for Neurodegenerative Diseases

Autor: Hasan Aldewachi, Radhwan N. Al-Zidan, Matthew T. Conner, Mootaz M. Salman

Publikováno v: Bioengineering, Vol 8, Iss 2, p 30 (2021)

Neurodegenerative diseases (NDDs) are incurable and debilitating conditions that result in progressive degeneration and/or death of nerve cells in the central nervous system (CNS). Identification of viable therapeutic targets and new treatments for C

Externí odkaz: https://doaj.org/article/d50b761220e2440cb90bc5efa8d28fd4

Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways.

Autor: Philip Kitchen, Fredrik Öberg, Jennie Sjöhamn, Kristina Hedfalk, Roslyn M Bill, Alex C Conner, Matthew T Conner, Susanna Törnroth-Horsefield

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143027 (2015)

Aquaporin membrane protein channels mediate cellular water flow. Human aquaporin 5 (AQP5) is highly expressed in the respiratory system and secretory glands where it facilitates the osmotically-driven generation of pulmonary secretions, saliva, sweat

Externí odkaz: https://doaj.org/article/999e92a6256e47d0a85df8d89f6d84c8

High-Throughput Screening Platforms in the Discovery of Novel Drugs for Neurodegenerative Diseases

Autor: Matthew T. Conner, Mootaz M. Salman, Hasan Aldewachi, Radhwan Nidal Al-Zidan

Publikováno v: Bioengineering, Vol 8, Iss 30, p 30 (2021)
Bioengineering

Neurodegenerative diseases (NDDs) are incurable and debilitating conditions that result in progressive degeneration and/or death of nerve cells in the central nervous system (CNS). Identification of viable therapeutic targets and new treatments for C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200879af96aa50749671497917ba085a
https://www.mdpi.com/2306-5354/8/2/30

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Autor: Charlotte Clarke-Bland, Andrea M. Halsey, Hiroaki Ishida, Matthew T. Conner, Alex C. Conner, Philip Kitchen, Ann Logan, Susanna Törnroth-Horsefield, Julie Winkel Missel, Mootaz M. Salman, Pontus Gourdon, Sharif Almutiri, Stefan Kreida, Hans J. Vogel, Zubair Ahmed, Roslyn M. Bill, Tamim Al-Jubair, Justin A. MacDonald

Publikováno v: Kitchen, P, Salman, M M, Halsey, A M, Clarke-Bland, C, MacDonald, J A, Ishida, H, Vogel, H J, Almutiri, S, Logan, A, Kreida, S, Al-Jubair, T, Winkel Missel, J, Gourdon, P, Törnroth-Horsefield, S, Conner, M T, Ahmed, Z, Conner, A C & Bill, R M 2020, ' Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema ', Cell, vol. 181, no. 4, pp. 784-799 . https://doi.org/10.1016/j.cell.2020.03.037
Cell

Summary Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c988cdd7f5d6e5a62e364529ce9b2792
https://curis.ku.dk/ws/files/244572535/OA_Targeting_Aquaporin_4_Subcellular_Localization_to_Treat_Central_Nervous_System_Edema.pdf

Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA‑MB‑231 breast cancer cell line

Autor: Matthew T. Conner, Simon J. Dunmore, David A. Nagel, James Brown, Eric J. Hill, Angel L. Armesilla, Muhammad Arif, Philip Kitchen, Roslyn M. Bill, Stephane R. Gross, Amtul R. Carmichael, Alex C. Conner

Publikováno v: Oncology Letters

Aquaporins are membrane proteins that regulate cellular water flow. Recently, aquaporins have been proposed as mediators of cancer cell biology. A subset of aquaporins, referred to as aquaglyceroporins are known to facilitate the transport of glycero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78676c918722526b4d03280a8b2855a0
https://doi.org/10.3892/ol.2018.8759