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pro vyhledávání: '"Matthew T, Burger"'
Autor:
Matthew T. Burger, Jocelyn Holash, Richard Zang, J. Alex Aycinena, Cornelia Bellamacina, Mika Lindvall, Gisele Nishiguchi, Jiong Lan, Wooseok Han, Christopher Wilson, Joerg Trappe, Peter Drueckes, Estelle Pfister, Audrey Kauffmann, Christine Fritsch, Tiffany Tsang, Jamie Narberes, Robert Warne, Paul Feucht, Michael Doyle, Jianjun Yu, Julie Chan, Stephen Basham, Xiao-Hong Niu, Jing Lu, Yumin Dai, Tatiana Zavorotinskaya, Marjorie Ison, Christie Fanton, Joseph Castillo, Min Chen, Yingyun Wang, John L. Langowski, Pablo D. Garcia
Purpose: PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this, we found that PIMs are highly expressed in human hematologic cancers and show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b7a0911566c282b44322df88773977
https://doi.org/10.1158/1078-0432.c.6522398
https://doi.org/10.1158/1078-0432.c.6522398
Autor:
Matthew T. Burger, Jocelyn Holash, Richard Zang, J. Alex Aycinena, Cornelia Bellamacina, Mika Lindvall, Gisele Nishiguchi, Jiong Lan, Wooseok Han, Christopher Wilson, Joerg Trappe, Peter Drueckes, Estelle Pfister, Audrey Kauffmann, Christine Fritsch, Tiffany Tsang, Jamie Narberes, Robert Warne, Paul Feucht, Michael Doyle, Jianjun Yu, Julie Chan, Stephen Basham, Xiao-Hong Niu, Jing Lu, Yumin Dai, Tatiana Zavorotinskaya, Marjorie Ison, Christie Fanton, Joseph Castillo, Min Chen, Yingyun Wang, John L. Langowski, Pablo D. Garcia
PDF file - 346KB, Supplementary Figure 1. Normal vs. Tumor expression of PIM kinases mRNA across 17 tissue types. Supplementary Figure 2. Comparison of LGB321 on-target activity vs. Previously described pan-PIM inhibitor. Supplementary Figure 3. KINO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cf370c3ede2546f0f7aab800bf1d63
https://doi.org/10.1158/1078-0432.22452158.v1
https://doi.org/10.1158/1078-0432.22452158.v1
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142741 (2015)
Toll-like receptors (TLRs) are important sensors of the innate immune system that recognize conserved structural motifs and activate cells via a downstream signaling cascade. The CD180/MD1 molecular complex is an unusual member of the TLR family, sin
Externí odkaz:
https://doaj.org/article/52fd7410c06e4ddba8312f9c98f35ea8
Autor:
Matthew T, Burger, Gisele, Nishiguchi, Wooseok, Han, Jiong, Lan, Robert, Simmons, Gordana, Atallah, Yu, Ding, Victoriano, Tamez, Yanchen, Zhang, Michelle, Mathur, Kristine, Muller, Cornelia, Bellamacina, Mika K, Lindvall, Richard, Zang, Kay, Huh, Paul, Feucht, Tatiana, Zavorotinskaya, Yumin, Dai, Steve, Basham, Julie, Chan, Elaine, Ginn, Alex, Aycinena, Jocelyn, Holash, Joseph, Castillo, John L, Langowski, Yingyun, Wang, Min Y, Chen, Amy, Lambert, Christine, Fritsch, Audry, Kauffmann, Estelle, Pfister, K Gary, Vanasse, Pablo D, Garcia
Publikováno v:
Journal of medicinal chemistry. 58(21)
Pan proviral insertion site of Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitors have recently begun to be tested in humans to assess whether pan PIM kinase inhibition may provide benefit to cancer patients. Herein, the synthesis, in vitro
Autor:
W. Clark Still, Matthew T. Burger
Publikováno v:
The Journal of Organic Chemistry. 62:4785-4790
A simple, dye(R)-labeled and conformationally restricted ionophore 2 was prepared and screened for peptide binding using solid-supported combinatorial libraries of 24 389 protected and unprotected tripeptides. The ionophore was found generally to bin
Publikováno v:
ChemInform. 28
Different synthetic strategies are required for the two kinds of libraries being developed for combinatoral chemistry. Preparation of a 'focused' library involves conversion of a known synthetic route to the solid-phase or automated format, whereas g
Publikováno v:
Current opinion in chemical biology. 1(1)
Different synthetic strategies are required for the two kinds of libraries being developed for combinatoral chemistry. Preparation of a 'focused' library involves conversion of a known synthetic route to the solid-phase or automated format, whereas g
Autor:
Matthew T. Burger, Gisele Nishiguchi, Wooseok Han, Jiong Lan, Robert Simmons, Gordana Atallah, Yu Ding, Victoriano Tamez, Yanchen Zhang, Michelle Mathur, Kristine Muller, Cornelia Bellamacina, MikaK. Lindvall, Richard Zang, Kay Huh, Paul Feucht, Tatiana Zavorotinskaya, Yumin Dai, Steve Basham, Julie Chan
Publikováno v:
Journal of Medicinal Chemistry; Nov2015, Vol. 58 Issue 21, p8373-8386, 14p
Autor:
Matthew T. Burger, W. Clark Still
Publikováno v:
The Journal of Organic Chemistry. 60:7382-7383
Publikováno v:
Journal of the American Chemical Society. 116:3593-3594