Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Matthew Stirling"'
Autor:
Brianna J. Stubbs, Pete J. Cox, Rhys D. Evans, Peter Santer, Jack J. Miller, Olivia K. Faull, Snapper Magor-Elliott, Satoshi Hiyama, Matthew Stirling, Kieran Clarke
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Background and aims: Currently there is considerable interest in ketone metabolism owing to recently reported benefits of ketosis for human health. Traditionally, ketosis has been achieved by following a high-fat, low-carbohydrate “ketogenic” die
Externí odkaz:
https://doaj.org/article/4785bd7e27a6422d91b18f2118b159b5
Autor:
Mark Rolfe, Julie X. Zhang, Gabriel S. Weatherhead, Christopher A. Tsu, Yuan Tian, Matthew Stirling, Marjorie S. Solomon, Corinne L. Reimer, Ashok D. Patil, Anne M. Mazzola, Jason Labutti, Lawrence R. Dick, J. Scott Daniels, Yueying Cao, Frank J. Bruzzese, Jonathan L. Blank, Mark J. Williamson
Supplementary Fig. S2 from Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d6b3c01afa13c5032c97a247196bc9
https://doi.org/10.1158/1535-7163.22484490
https://doi.org/10.1158/1535-7163.22484490
Autor:
Mark Rolfe, Julie X. Zhang, Gabriel S. Weatherhead, Christopher A. Tsu, Yuan Tian, Matthew Stirling, Marjorie S. Solomon, Corinne L. Reimer, Ashok D. Patil, Anne M. Mazzola, Jason Labutti, Lawrence R. Dick, J. Scott Daniels, Yueying Cao, Frank J. Bruzzese, Jonathan L. Blank, Mark J. Williamson
Supplementary Table S1 from Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e3daae3978bdef7d650a92159c9248
https://doi.org/10.1158/1535-7163.22484487.v1
https://doi.org/10.1158/1535-7163.22484487.v1
Autor:
Mark Rolfe, Julie X. Zhang, Gabriel S. Weatherhead, Christopher A. Tsu, Yuan Tian, Matthew Stirling, Marjorie S. Solomon, Corinne L. Reimer, Ashok D. Patil, Anne M. Mazzola, Jason Labutti, Lawrence R. Dick, J. Scott Daniels, Yueying Cao, Frank J. Bruzzese, Jonathan L. Blank, Mark J. Williamson
Strains within the genus Salinospora have been shown to produce complex natural products having antibiotic and antiproliferative activities. The biochemical basis for the cytotoxic effects of salinosporamide A has been linked to its ability to inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5252834913f8cac5179e0fd33b018f31
https://doi.org/10.1158/1535-7163.c.6531429
https://doi.org/10.1158/1535-7163.c.6531429
Publikováno v:
Green Chemistry. 23:788-795
Reducing or eliminating organic solvent use in pharmaceutical manufacturing is perhaps the most effective way to reduce the environmental, health, and safety impacts of drug substance manufacturing. With this in mind, we have developed a process to m
Autor:
Todd B. Sells, Ryan Chau, Jeffrey A. Ecsedy, Rachel E. Gershman, Kara Hoar, Jessica Huck, David A. Janowick, Vivek J. Kadambi, Patrick J. LeRoy, Matthew Stirling, Stephen G. Stroud, Tricia J. Vos, Gabriel S. Weatherhead, Deborah R. Wysong, Mengkun Zhang, Suresh K. Balani, Joseph B. Bolen, Mark G. Manfredi, Christopher F. Claiborne
Publikováno v:
ACS Medicinal Chemistry Letters. 6:630-634
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, select
Autor:
Hiroki Wada, Tony Raynham, Rebekah E. Beevers, Jeremy Major, Jess Taylor, Neil Grimster, David W. Walker, Parminder Kaur Ruprah, Svenja Burckhardt, Hannah Fiona Sore, James Nally, Alison Reid, Steven P. Langston, Andrew H. Henry, Helen J. Payne, Yvonne Ferguson, John C Reader, Eva Figueroa, Michael Shaw, Abid Masood, Nawaz Mohammed Khan, Valérie Reader, Lloyd J. Payne, Kerry Jenkins, Stephen Thompson, Ruth Adams, Matthew Stirling, Richard J. Boyce, Adam C. Talbot, Gilles Raphy, Jones Mark, Robert Judkins, James M. Cobb, Justine Y.Q. Lai
Publikováno v:
Medicinal Research Reviews. 25:310-330
This work describes the preparation of approximately 13,000 compounds for rapid identification of hits in high-throughput screening (HTS). These compounds were designed as potential serine/threonine or tyrosine kinase inhibitors. The library consists
Autor:
Matthew Stirling, Valerie Reader, Enrique Luis Michelotti, Colin M. Tice, John C. Reader, Bridget A. Donohue
Publikováno v:
Journal of Combinatorial Chemistry. 4:23-32
A library of 422 1-(2-thiazolyl)-5-(trifluoromethyl)pyrazole-4-carboxamides was prepared in five steps using solution-phase chemistry. The first step in the synthesis was the reaction of ethyl 2-ethoxymethylene-3-oxo-4,4,4-trifluorobutanoate with thi
Autor:
Bridget A. Donohue, Enrique Luis Michelotti, Matthew Stirling, Colin M. Tice, John C. Reader, Valerie Reader
Publikováno v:
ChemInform. 33
A library of 422 1-(2-thiazolyl)-5-(trifluoromethyl)pyrazole-4-carboxamides was prepared in five steps using solution-phase chemistry. The first step in the synthesis was the reaction of ethyl 2-ethoxymethylene-3-oxo-4,4,4-trifluorobutanoate with thi
Autor:
Mark J. Williamson, Jonathan L. Blank, Frank J. Bruzzese, Yueying Cao, J. Scott Daniels, Lawrence R. Dick, Jason Labutti, Anne M. Mazzola, Ashok D. Patil, Corinne L. Reimer, Marjorie S. Solomon, Matthew Stirling, Yuan Tian, Christopher A. Tsu, Gabriel S. Weatherhead, Julie X. Zhang, Mark Rolfe
Publikováno v:
Molecular cancer therapeutics. 5(12)
Strains within the genus Salinospora have been shown to produce complex natural products having antibiotic and antiproliferative activities. The biochemical basis for the cytotoxic effects of salinosporamide A has been linked to its ability to inhibi