Výsledky vyhledávání - "Matthew Sarkisian"

Abstract 5961: Inhibition of AURKA destabilizes glioblastoma primary cilia and sensitizes cells to tumor treating fields (TTFields) in vitro and ex vivo

Autor: Jia Tian, Julianne Mallinger, Ping Shi, Dahao Ling, Loic Deleyrolle, Min Lin, Habibeh Khoshbouei, Matthew Sarkisian

Publikováno v: Cancer Research. 83:5961-5961

Tumor Treating Fields (TTFields) can prolong survival of patients with glioblastoma (GBM), but GBM cells still escape this therapy requiring an urgent need for new or adjunct treatments. Recently we reported that TTFields disrupt primary cilia on GBM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f7838b23923dd15df1d58f3d1f59e92
https://doi.org/10.1158/1538-7445.am2023-5961

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Abstract 904: Optimizing CAR T therapy via metabolic engineering for the treatment of glioblastoma

Autor: Tanya Ghosh, Avirup Chakraborty, Linchun Jin, Diana Feier, Aryeh Silver, Maryam Rahman, Catherine Flores, Matthew Sarkisian, Jianping Huang, Duane A. Mitchell, Loic P. Deleyrolle

Publikováno v: Cancer Research. 83:904-904

Glioblastoma represent a great challenge and current therapies are negligibly effective, with disease recurrence being inevitable. T cell therapy has emerged as a viable treatment for brain malignancies. While promising, the efficacy of this approach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3fac5e551fee2bb4182bce43ec4104e
https://doi.org/10.1158/1538-7445.am2023-904

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EXTH-38. NEOADJUVANT PD1 BLOCKADE ALTERS THE TUMOR IMMUNE MICROENVIRONMENT AFTER SURGERY IN A PRECLINICAL MODEL OF RECURRENT GLIOBLASTOMA

Autor: Lan Hoang-Minh, Kelena Klippel, Bently Doonan, Christina Von Roemeling, Vrunda Trivedi, Changlin Yang, Akshayaa Sriharan, Connor Francis, David Shin, Aida Karachi, Zhanna Galochkina, Matthew Sarkisian

Publikováno v: Neuro-Oncology. 24:vii217-vii218

SIGNIFICANCE Promising clinical trials for glioblastoma are evaluating the efficacy of neoadjuvant immunotherapy in the context of recurrent tumor surgery. OBJECTIVE We investigated the effects of neoadjuvant PD1 blockade on the glioma tumor microenv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcba1f4ba0f75fb816c1336f2485a753
https://doi.org/10.1093/neuonc/noac209.836

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TMIC-56. TUMOR CELL ARCHITECTURAL HETEROGENEITY AND SPATIAL INTERACTIONS WITH THE TUMOR IMMUNE MICROENVIRONMENT IN GBM

Autor: Aryeh Silver, Diana Feier, Guimei Tian, Michael Andrews, Mariana Dajac, Changlin Yang, Tanya Ghosh, Dongtao Fu, Christina Von Roemeling, Maryam Rahman, Matthew Sarkisian, Jianping Huang, Jeffrey Harrison, Duane Mitchell, Loic Deleyrolle

Publikováno v: Neuro-Oncology. 24:vii283-vii284

INTRODUCTION Glioblastoma (GBM) contains cell populations with distinct metabolic requirements, with fast-cycling cells harnessing aerobic glycolysis, and treatment-resistant slow-cycling cells (SCCs) preferentially engaging lipid metabolism. The int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4a300cc812a51cbbc92acf90cdad288
https://doi.org/10.1093/neuonc/noac209.1100

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TMET-21. ENHANCING THE METABOLIC FITNESS OF T CELLS TO TREAT BRAIN TUMORS

Autor: Tanya Ghosh, Linchun Jin, Diana Feier, Aryeh Silver, Guimei Tian, Mariana Dajac, Maryam Rahman, Catherine Flores, Matthew Sarkisian, Jianping Huang, Duane Mitchell, Loic Deleyrolle

Publikováno v: Neuro-Oncology. 24:vii266-vii266

INTRODUCTION Glioblastoma is a challenge for neuro-oncologists and current therapies are minimally effective. Standard-of- care treatment is almost inevitably followed by disease recurrence. Adoptive T cell transfer has emerged as a viable therapeuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::754d3d4a8ea15558210e5eb9f32eb283
https://doi.org/10.1093/neuonc/noac209.1026

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TMIC-32. TUMOR CELL CILIA ASSOCIATE WITH SPECIFIC IMMUNE CELL POPULATIONS IN HUMAN AND MOUSE MODELS OF GBM

Autor: Loic Deleyrolle, Jeffrey Harrison, Gregory Takacs, Matthew Sarkisian

Publikováno v: Neuro-Oncology. 24:vii278-vii278

INTRODUCTION Glioblastoma (GBM) typically recurs after standard of care therapies. A major obstacle is that GBMs employ various mechanisms to suppress the host immune system, preventing destruction and removal of cancer cells. A better understanding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15925d80259e9f86433da1a15ae2aa21
https://doi.org/10.1093/neuonc/noac209.1076

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Abstract 3252: Tumor treating fields suppression of ciliogenesis enhances temozolomide toxicity

Autor: Ping Shi, Jia Tian, Brittany Ulm, Julianne Mallinger, Habibeh Khoshbouei, Loic Deleyrolle, Matthew Sarkisian

Publikováno v: Cancer Research. 82:3252-3252

Tumor Treating Fields (TTFields) are low intensity, alternating intermediate frequency (200kHz) electrical fields that extend survival of glioblastoma patients receiving maintenance temozolomide (TMZ) chemotherapy. How TTFields exert efficacy on canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26a05295f552ca8b33a4a9c1a9c1526b
https://doi.org/10.1158/1538-7445.am2022-3252

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