Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Matthew S. Wilken"'
Autor:
Leah S. VandenBosch, Stefanie G. Wohl, Matthew S. Wilken, Marcus Hooper, Connor Finkbeiner, Kristen Cox, Laura Chipman, Thomas A. Reh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract Diseases and damage to the retina lead to losses in retinal neurons and eventual visual impairment. Although the mammalian retina has no inherent regenerative capabilities, fish have robust regeneration from Müller glia (MG). Recently, we h
Externí odkaz:
https://doaj.org/article/2236c493995b463399eb89df70e4b027
Autor:
Nikolas L. Jorstad, Matthew S. Wilken, Levi Todd, Connor Finkbeiner, Paul Nakamura, Nicholas Radulovich, Marcus J. Hooper, Alex Chitsazan, Brent A. Wilkerson, Fred Rieke, Thomas A. Reh
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2195-2208.e5 (2020)
Summary: Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates. We find that this process can be induced in mouse MG, after injury, by transgenic expression of the proneural transcription factor Ascl1 and the HDAC i
Externí odkaz:
https://doaj.org/article/92d77537dc5a471fb270672b687e7c22
Autor:
Stefanie G. Wohl, Thomas A. Reh, Kristen E. Cox, Connor Finkbeiner, Matthew S. Wilken, Laura Chipman, Marcus J. Hooper, Leah S. VandenBosch
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
Diseases and damage to the retina lead to losses in retinal neurons and eventual visual impairment. Although the mammalian retina has no inherent regenerative capabilities, fish have robust regeneration from Müller glia (MG). Recently, we have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc02b6e75d03dc42eee70368e8d2bc7d
https://doaj.org/article/2236c493995b463399eb89df70e4b027
https://doaj.org/article/2236c493995b463399eb89df70e4b027
Autor:
Matthew S. Wilken, Florian Busch, Zibo Chen, Ryan Kibler, Galen Dods, Vicki H. Wysocki, Christie Ciarlo, Mengxuan Jia, Hanna Liao, Michael C. Jewett, John A. Stamatoyannopoulos, Jocelynn R. Pearl, Basile I. M. Wicky, Shon Green, David Baker, Zachary L. VanAernum, Hana El-Samad, Scott E. Boyken, Andrew Hunt
Publikováno v:
Science
Designer gates Signaling in cells can occur through protein-protein interactions. Chen et al. describe the design of logic gates that can regulate protein association. The gates were built from small, designed proteins that all have a similar structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8ef1f35b344f8981120798e53c38a6
https://doi.org/10.1126/science.aay2790
https://doi.org/10.1126/science.aay2790
Autor:
Thomas A. Reh, Nick Radulovich, Paul A. Nakamura, Levi Todd, Nikolas L. Jorstad, Matthew S. Wilken, Fred Rieke, Brent A. Wilkerson, Marcus J. Hooper, Alex Chitsazan
Müller glia can serve as a source for retinal regeneration in some non-mammalian vertebrates. Recently we found that this process can be induced in mouse Müller glia after injury, by combining transgenic expression of the proneural transcription fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cec3fd9a12e6ae04b75df34e5ac424d
https://doi.org/10.1101/753483
https://doi.org/10.1101/753483
Autor:
Laura Chipman, Matthew S. Wilken, Thomas A. Reh, Leah S. VandenBosch, Stefanie G. Wohl, Kristen E. Cox
Diseases and damage to the retina lead to losses in retinal neurons and eventual visual impairment. Although the mammalian retina has no inherent regenerative capabilities, fish have robust regeneration from Müller glia (MG). Recently, we have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f803acfbb1796d5e9b0bee112b667b11
Autor:
Thomas A. Reh, Connor Finkbeiner, Paul A. Nakamura, Nikolas L. Jorstad, Matthew S. Wilken, Brent A. Wilkerson, Alex Chitsazan, Levi Todd, Marcus J. Hooper, Nicholas Radulovich, Fred Rieke
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2195-2208.e5 (2020)
Summary: Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates. We find that this process can be induced in mouse MG, after injury, by transgenic expression of the proneural transcription factor Ascl1 and the HDAC i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53df093df4fba9d71f57edcd13a240e8
https://pubmed.ncbi.nlm.nih.gov/32075759
https://pubmed.ncbi.nlm.nih.gov/32075759
Autor:
Olivia Bermingham-McDonogh, Matthew S. Wilken, Thomas A. Reh, Brent A. Wilkerson, Leah S. VandenBosch, Alex Chitsazan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Hearing loss is often due to the absence or the degeneration of hair cells in the cochlea. Understanding the mechanisms regulating the generation of hair cells may therefore lead to better treatments for hearing disorders. To elucidate the transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c894e171cc097db6ce94ffa9344cc43
https://doi.org/10.1038/s41598-019-45515-2
https://doi.org/10.1038/s41598-019-45515-2
Autor:
Thomas A. Reh, Matthew S. Wilken
Publikováno v:
Current Opinion in Genetics & Development. 40:57-64
Retinal regeneration from resident Müller glia cells is robust in teleost fish, but is severely limited in birds and mammals. After neurotoxic injury, chick Müller glia can proliferate, and activate neurogenic genes, but they display limited capaci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf4fab6e74938abebd89295ead7b56c
https://doi.org/10.1016/j.gde.2016.05.028
https://doi.org/10.1016/j.gde.2016.05.028
Autor:
Thomas A. Reh, Yumi Ueki, Olivia Bermingham-McDonogh, Matthew S. Wilken, Laura Chipman, Kristen E. Cox
Publikováno v:
Development (Cambridge, England)
The primary glial cells in the retina, the Müller glia, differentiate from retinal progenitors in the first postnatal week. CNTF/LIF/STAT3 signaling has been shown to promote their differentiation; however, another key glial differentiation signal,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bd7d8642e074c46a86aae937d4cf1a
https://doi.org/10.1242/dev.118745
https://doi.org/10.1242/dev.118745