Antibody-mediated depletion of select leukocyte subsets in blood and tissue of nonhuman primates

Autor: Matthew S. Sutton, Allison N. Bucsan, Chelsea C. Lehman, Megha Kamath, Supriya Pokkali, Diogo M. Magnani, Robert Seder, Patricia A. Darrah, Mario Roederer

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Understanding the immunological control of pathogens requires a detailed evaluation of the mechanistic contributions of individual cell types within the immune system. While knockout mouse models that lack certain cell types have been used to help de

Externí odkaz: https://doaj.org/article/95faee24c36f4d139c41cce54445ee40

Latent Mycobacterium tuberculosis Infection Is Associated With a Higher Frequency of Mucosal-Associated Invariant T and Invariant Natural Killer T Cells

Autor: Dominic Paquin-Proulx, Priscilla R. Costa, Cassia G. Terrassani Silveira, Mariana P. Marmorato, Natalia B. Cerqueira, Matthew S. Sutton, Shelby L. O’Connor, Karina I. Carvalho, Douglas F. Nixon, Esper G. Kallas

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Increasing drug resistance and the lack of an effective vaccine are the main factors contributing to Mycobacterium tuberculosis (Mtb) being a major cause of death globally. Despite intensive research efforts, it is not well understood why some indivi

Externí odkaz: https://doaj.org/article/bc3008eb4bfb4fadafa584ab5605eb04

CD8β Depletion Does Not Prevent Control of Viral Replication or Protection from Challenge in Macaques Chronically Infected with a Live Attenuated Simian Immunodeficiency Virus

Autor: Gabrielle L. Barry, Alexis J. Balgeman, Thomas C. Friedrich, Nancy J. Sullivan, Annie W. Lau-Kilby, Shelby L. O’Connor, Andrea M. Weiler, Amy L. Ellis-Connell, John R. Mascola, Yan Zhou, Matthew S. Sutton, Rosemarie D. Mason, Scott Hetzel, Kristin K. Biris, Mario Roederer

Publikováno v: Journal of Virology. 93

We evaluated the contribution of CD8αβ(+) T cells to control of live-attenuated simian immunodeficiency virus (LASIV) replication during chronic infection and subsequent protection from pathogenic SIV challenge. Unlike previous reports with a CD8α

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2d48811429189e652b29045f176860
https://doi.org/10.1128/jvi.00537-19

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

Autor: Marie Pancera, Mark K. Louder, Stephen D. Schmidt, Matthew S. Sutton, Lawrence Shapiro, Peter D. Kwong, Jinal N. Bhiman, Amarendra Pegu, Mangaiarkarasi Asokan, Penny L. Moore, Robert T. Bailer, Ryan P. Staupe, Sijy O'Dell, John R. Mascola, Salim Abdool-Karim, Chaim A. Schramm, Evan M. Cale, Lynn Morris, Marissa C. Jarosinski, Rebecca M. Lynch, Keyun Wang, Jason Gorman, Nicole A. Doria-Rose, Gwo-Yu Chuang, Aliaksandr Druz, Krisha McKee, Constantinos Kurt Wibmer, Barton F. Haynes, Nigel Garrett, Isabella R. Fraschilla, Ryan S. Roark, Michael J. Ernandes

Publikováno v: Journal of Virology. 90:76-91

The epitopes defined by HIV-1 broadly neutralizing antibodies (bNAbs) are valuable templates for vaccine design, and studies of the immunological development of these antibodies are providing insights for vaccination strategies. In addition, the most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359db5eeeae922e0cc80ef3b6f9fe7de
https://doi.org/10.1128/jvi.01791-15

Latent Mycobacterium tuberculosis Infection Is Associated With a Higher Frequency of Mucosal-Associated Invariant T and Invariant Natural Killer T Cells

Autor: Mariana P Marmorato, Shelby L. O’Connor, Matthew S. Sutton, Cassia G. T. Silveira, Karina I. Carvalho, Esper G. Kallas, Priscilla R. Costa, Douglas F. Nixon, Natalia B. Cerqueira, Dominic Paquin-Proulx

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Immunology, Vol 9 (2018)

Increasing drug resistance and the lack of an effective vaccine are the main factors contributing to Mycobacterium tuberculosis (Mtb) being a major cause of death globally. Despite intensive research efforts, it is not well understood why some indivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e19df14f960436560588ace1bd1e5df