Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Matthew S. Kennedy"'
Autor:
Maria Chatzopoulou, Katrina S. Madden, Liam J. Bromhead, Christopher Greaves, Thomas J. Cogswell, Solange Da Silva Pinto, Sébastien R. G. Galan, Irene Georgiou, Matthew S. Kennedy, Alice Kennett, Geraint Apps, Angela J. Russell, Graham M. Wynne
Publikováno v:
ACS Medicinal Chemistry Letters. 13:262-270
Palladium-catalyzed reactions are among the most commonly used procedures in organic synthesis. The products have a range of uses, including as intermediates in total synthesis and as screening compounds for drug discovery or agrochemical projects. D
Autor:
Matthew S. Kennedy, Paul M. Roberts, Stephen G. Davies, Aileen B. Frost, James E. Thomson, Ai M. Fletcher
Publikováno v:
Tetrahedron. 72:2139-2163
All rights reserved.A range of enantiopure 1,2,3,4-tetrahydroisoquinolines have been prepared directly from α-hydroxy-β-amino esters. Activation of the α-hydroxy group upon treatment with Tf2O and 2,6-di-tert-butyl-4-methylpyridine promotes azirid
Publikováno v:
Tetrahedron. 74(51)
A divergent strategy for the asymmetric syntheses of d -fagomine and three of its diastereoisomers has been developed. The diastereoselective conjugate addition of an enantiopure lithium amide to an α,β-unsaturated ester was used as the key step to
Autor:
Catherine J. Greenaway, James E. Thomson, Matthew S. Kennedy, Stephen G. Davies, Christoph Mayer, Ai M. Fletcher, Paul M. Roberts
Publikováno v:
Tetrahedron. 74(38)
A total of nine enantiopure syn-β-substituted-α-amino acids have been synthesised, comprising both syn-β-hydroxy-α-amino acids and syn-β-fluoro-α-amino acids. The key step in the synthetic strategy towards these syn-β-substituted-α-amino acid
Autor:
Matthew S. Kennedy, Ai M. Fletcher, James E. Thomson, Stephen G. Davies, Kristína Csatayová, Thomas R. Fowler, Paul M. Roberts
Publikováno v:
Journal of Organic Chemistry. 82(23)
The asymmetric syntheses of a range of N- and O-protected 3-deoxy-3-aminosphingoid bases have been achieved using two complementary approaches. dl-Serine was converted to a racemic N,N-dibenzyl-protected γ-amino-α,β-unsaturated ester which was res
Autor:
Aileen B. Frost, Ai M. Fletcher, Matthew S. Kennedy, Stephen G. Davies, Paul M. Roberts, James E. Thomson
Publikováno v:
ChemInform. 47
The synthesis of the enantiopure tetrahydroisoquinolines is achieved by a short sequence consisting of aminohydroxylation of cinnamates (I) with a chiral bis-benzylic amine (II) followed by activation of the α-hydroxy group of products (III).