Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Matthew S. J. Mangan"'
Autor:
Matthew S J Mangan, Friederike Gorki, Karoline Krause, Alexander Heinz, Anne Pankow, Thomas Ebert, Dieter Jahn, Karsten Hiller, Veit Hornung, Marcus Maurer, Florian I Schmidt, Ralf Gerhard, Eicke Latz
Publikováno v:
PLoS Biology, Vol 20, Iss 11, p e3001351 (2022)
Pyrin is a cytosolic immune sensor that nucleates an inflammasome in response to inhibition of RhoA by bacterial virulence factors, triggering the release of inflammatory cytokines, including IL-1β. Gain-of-function mutations in the MEFV gene encodi
Externí odkaz:
https://doaj.org/article/d2b24fda68f24955ab6c72841f51a496
Autor:
Tomasz Próchnicki, Matilde B. Vasconcelos, Kim S. Robinson, Matthew S. J. Mangan, Dennis De Graaf, Kateryna Shkarina, Marta Lovotti, Lena Standke, Romina Kaiser, Rainer Stahl, Fraser G. Duthie, Maximilian Rothe, Kateryna Antonova, Lea-Marie Jenster, Zhi Heng Lau, Sarah Rösing, Nora Mirza, Clarissa Gottschild, Dagmar Wachten, Claudia Günther, Thomas A. Kufer, Florian I. Schmidt, Franklin L. Zhong, Eicke Latz
Publikováno v:
Nature immunology 24(4), 595-603 (2023). doi:10.1038/s41590-023-01451-y
Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form inflammasome complexes with the adapter ASC and caspase-1, inducing gasdermin D (GSDMD)-dependent cell death and maturation and release of IL-1β and IL-18. The triggers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951cef744dde927be85ce561d1cb4398
Autor:
Anil Akbal, Alesja Dernst, Marta Lovotti, Matthew S. J. Mangan, Róisín M. McManus, Eicke Latz
Publikováno v:
Cellular & molecular immunology 19(11), 1201-1214 (2022). doi:10.1038/s41423-022-00922-w
Cellular and Molecular Immunology
Cellular and Molecular Immunology
NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon detection of an activating stimulus, NLRP3 transitions from an inactive homo-oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce1c4f5416b34b342207670b67960e6
https://pub.dzne.de/record/165241
https://pub.dzne.de/record/165241
Autor:
Matthew S. J. Mangan, Friederike Gorki, Karoline Krause, Alexander Heinz, Anne Pankow, Thomas Ebert, Dieter Jahn, Karsten Hiller, Veit Hornung, Marcus Maurer, Florian I. Schmidt, Ralf Gerhard, Eicke Latz
Publikováno v:
PLoS biology 20(11), e3001351 (2022). doi:10.1371/journal.pbio.3001351
PLoS Biology
PLoS Biology
Pyrin is a cytosolic immune sensor that nucleates an inflammasome in response to inhibition of RhoA by bacterial virulence factors, triggering the release of inflammatory cytokines, including IL-1β. Gain-of-function mutations in the MEFV gene encodi
Autor:
Matthew S J, Mangan, Catherina H, Bird, Dion, Kaiserman, Anthony Y, Matthews, Corinne, Hitchen, David L, Steer, Philip E, Thompson, Phillip I, Bird
Publikováno v:
The Journal of biological chemistry. 291(7)
The intracellular protease inhibitor Sb9 (SerpinB9) is a regulator of the cytotoxic lymphocyte protease GzmB (granzyme B). Although GzmB is primarily involved in the destruction of compromised cells, recent evidence suggests that it is also involved