Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Matthew S. Elitt"'
Autor:
Angela M. Lager, Olivia G. Corradin, Jared M. Cregg, Matthew S. Elitt, H. Elizabeth Shick, Benjamin L. L. Clayton, Kevin C. Allan, Hannah E. Olsen, Mayur Madhavan, Paul J. Tesar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mo
Externí odkaz:
https://doaj.org/article/71dbdedc40fa404b962276780906a9a8
Autor:
Matthew S. Elitt, H. Elizabeth Shick, Mayur Madhavan, Kevin C. Allan, Benjamin L.L. Clayton, Chen Weng, Tyler E. Miller, Daniel C. Factor, Lilianne Barbar, Baraa S. Nawash, Zachary S. Nevin, Angela M. Lager, Yan Li, Fulai Jin, Drew J. Adams, Paul J. Tesar
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 711-726 (2018)
Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancem
Externí odkaz:
https://doaj.org/article/85ceab688bb44f7d8336a4d35cb11973
Autor:
Kevin C. Allan, Tyler E. Miller, Andrew R. Morton, Marissa A. Scavuzzo, Matthew S. Elitt, Benjamin L.L. Clayton, Lucille R. Hu, Jost K. Vrabic, Hannah E. Olsen, Daniel C. Factor, Jonathan E. Henninger, Richard A. Young, Charles Y. Lin, Peter C. Scacheri, Paul J. Tesar
SUMMARYPluripotent stem cells (PSCs) provide an unlimited source for generating somatic cell types. However, generating fully mature cells constitutes a bottleneck for realizing their full potential in research and medicine. Here, we report a transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ee17af1d86d3aea0ee785bea3821dc2
https://doi.org/10.1101/2022.11.17.516981
https://doi.org/10.1101/2022.11.17.516981
Autor:
Joel L. Sax, Samantha N. Hershman, Zita Hubler, Dharmaraja Allimuthu, Matthew S. Elitt, Ilya Bederman, Drew J. Adams
Regeneration of myelin in the CNS is being pursued as a potential therapeutic approach for multiple sclerosis. Several labs have reported small molecules that promote oligodendrocyte formation and remyelination in vivo. Recently, we reported that man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e56aac94439e508a8ac34538192f20
https://doi.org/10.1101/2022.06.21.497032
https://doi.org/10.1101/2022.06.21.497032
Autor:
Ronald A. Conlon, Berit Powers, Matthew S. Elitt, Daniela Schlatzer, H. Elizabeth Shick, Yuka Maeno-Hikichi, Lilianne Barbar, David F. LePage, Weihong Jiang, Hannah E. Olsen, Hien T Zhao, Stevephen Hung, Adam Swayze, Frank Rigo, Paul J. Tesar, Kevin C. Allan, Zachary S. Nevin, Baraa S. Nawash, Masahiro Hitomi, Artur S. Gevorgyan, Mayur Madhavan
Publikováno v:
Nature
Mutations in PLP1, the gene that encodes proteolipid protein (PLP), result in failure of myelination and neurological dysfunction in the X-chromosome-linked leukodystrophy Pelizaeus–Merzbacher disease (PMD)1,2. Most PLP1 mutations, including point
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316136b1462be634a5e5c31e077ee96d
http://europepmc.org/articles/PMC7810164
http://europepmc.org/articles/PMC7810164
Publikováno v:
Ophthalmic Genetics. 41:101-107
Purpose: Cutis marmorata telangiectatica congenita (CMTC) is a rare congenital disorder typified by localized or generalized cutaneous vascular anomalies, which dissipate over time. We review the diagnostic approach to CMTC and present a comprehensiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1537289f19527832fad10ddb32cc699
https://doi.org/10.1080/13816810.2020.1744018
https://doi.org/10.1080/13816810.2020.1744018
Autor:
Yan Li, Matthew S. Elitt, Zachary S. Nevin, Paul J. Tesar, Angela M. Lager, H. Elizabeth Shick, Chen Weng, Drew J. Adams, Mayur Madhavan, Tyler E. Miller, Kevin C. Allan, Lilianne Barbar, Fulai Jin, Daniel C. Factor, Baraa S. Nawash, Benjamin L.L. Clayton
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 711-726 (2018)
Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667b09ef40330db9dbda4a2c78c57762
http://www.sciencedirect.com/science/article/pii/S2213671118303205
http://www.sciencedirect.com/science/article/pii/S2213671118303205
Autor:
William K. Wilson, Matthew S. Elitt, Dharmaraja Allimuthu, Paul J. Tesar, Ilya Bederman, Mayur Madhavan, Franz Bracher, H. Elizabeth Shick, Martin Giera, Joel L. Sax, Jing Jin, Yuriy Fedorov, Eric Garrison, Zita Hubler, Drew J. Adams, Kevin C. Allan, Robert H. Miller, Daniel C. Factor, Matthew A. Thompson, Molly Karl, Zachary S. Nevin
Publikováno v:
Nature, 560(7718), 372
Nature
Nature
Regeneration of myelin is mediated by oligodendrocyte progenitor cells (OPCs), an abundant stem cell population in the CNS and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the central nervous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bd92c8bbc40fd074b077d070760713
https://doi.org/10.1038/s41586-018-0360-3
https://doi.org/10.1038/s41586-018-0360-3
Autor:
Masahiro Hitomi, Ronald A. Conlon, Berit Powers, Matthew S. Elitt, Baraa S. Nawash, Zachary S. Nevin, Frank Rigo, David F. LePage, H. Elizabeth Shick, Weihong Jiang, Mayur Madhavan, Paul J. Tesar, Hannah E. Olsen, Kevin C. Allan, Lilianne Barbar, Yuka Maeno-Hikichi
Mutations in proteolipid protein 1 (PLP1) result in failure of myelination and severe neurological dysfunction in the X-linked pediatric leukodystrophy Pelizaeus-Merzbacher disease (PMD). The majority of PLP1 variants, including supernumerary copies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb9aef0fb00a04d13ee97f5b90e39d5
Autor:
Jared M. Cregg, Benjamin L.L. Clayton, Olivia Corradin, Angela M. Lager, Mayur Madhavan, H. Elizabeth Shick, Kevin C. Allan, Paul J. Tesar, Hannah E. Olsen, Matthew S. Elitt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Oligodendrocyte dysfunction underlies many neurological disorders, but rapid assessment of mutation-specific effects in these cells has been impractical. To enable functional genetics in oligodendrocytes, here we report a highly efficient method for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba808321f8673eb923826fd9adceee21
https://doi.org/10.1038/s41467-018-06102-7
https://doi.org/10.1038/s41467-018-06102-7