Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Matthew S. Addie"'
Autor:
Matthew S. Addie, Richard J. K. Taylor
Publikováno v:
ARKIVOC, Vol 2000, Iss 5, Pp 660-666 (2000)
Externí odkaz:
https://doaj.org/article/4a9ff891c1fd42f2aff0775943b11c1a
Publikováno v:
Synlett. 2012:285-289
Heteroaryl amines readily undergo Buchwald-Hartwig amination reactions with a range of aryl and heteroaryl bromides at room temperature using t-BuXPhos Pd-precatalyst and NaOt-Bu. The pharmaceutically attractive biaryl amines are generally formed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8b723444d7abd623f21a5496b9bc7b7
https://doi.org/10.1055/s-0031-1290069
https://doi.org/10.1055/s-0031-1290069
Autor:
Michael R. Webb, Xavier Franci, Mathieu Pizzonero, Richard J. K. Taylor, Craig S. Donald, James Dale, Matthew S. Addie, Catherine M. Crawforth
Publikováno v:
Tetrahedron. 64:4778-4791
The Stille coupling between a common oxazole vinyl iodide and stereodefined stannyl-diene units is described as the cornerstone of a unified synthetic route to the inthomycin family of bioactive Streptomyces metabolites. This procedure has been utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90c80ddc646b91eed52e9f6a0400deaf
https://doi.org/10.1016/j.tet.2008.01.116
https://doi.org/10.1016/j.tet.2008.01.116
Autor:
Richard J. K. Taylor, Matthew S. Addie
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :527-531
Ultrasound-promoted desulfonylation of 5-substituted 4-tosyloxazoles, prepared from tosylmethyl isocyanide and carboxylic acid chlorides or by dianion chemistry, leads to 5-monosubstituted oxazoles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3de27aa8cf4bc558d5ad71eaaadb97e9
https://doi.org/10.1039/a908987j
https://doi.org/10.1039/a908987j
Autor:
Graeme C. Moody, Alleyn T. Plowright, J. Matthew Wood, Matthew S. Addie, Scott Boyd, Paul D. Kemmitt, David Whalley, Chris Sheldon, Andrew V. Turnbull, Stephen Chapman, Andrew G. Leach, Pablo Morentin Gutierrez, Paul Schofield, Linda K. Buckett, William McCoull, Nicholas John Newcombe, Alan Martin Birch, Chloe Jenner, Martin J. Packer, Thorsten Nowak, Robert D. M. Davies, Susan Birtles, Steven Wang, Steve Stokes, Roger John Butlin, Suzanne S. Bowker, John Revill, Craig S. Donald, Clive Green
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(12)
A novel series of DGAT-1 inhibitors was discovered from an oxadiazole amide high throughput screening (HTS) hit. Optimisation of potency and ligand lipophilicity efficiency (LLE) resulted in a carboxylic acid containing clinical candidate 53 (AZD3988
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e16429eb9afcdf02cbee31792660806
https://pubmed.ncbi.nlm.nih.gov/22608962
https://pubmed.ncbi.nlm.nih.gov/22608962
Autor:
Matthew S. Addie, Richard J. K. Taylor
Publikováno v:
ChemInform. 31
Ultrasound-promoted desulfonylation of 5-substituted 4-tosyloxazoles, prepared from tosylmethyl isocyanide and carboxylic acid chlorides or by dianion chemistry, leads to 5-monosubstituted oxazoles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a8a962bce8259168064e79efddd1cd1
https://doi.org/10.1002/chin.200022104
https://doi.org/10.1002/chin.200022104
Autor:
Matthew S. Addie, Michael R. Webb, Mathieu Pizzonero, Catherine M. Crawforth, Craig S. Donald, Richard J. K. Taylor, Xavier Franci, James Dale
Publikováno v:
ChemInform. 39
The Stille coupling between a common oxazole vinyl iodide and stereodefined stannyl-diene units is described as the cornerstone of a unified synthetic route to the inthomycin family of bioactive Streptomyces metabolites. This procedure has been utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f94daac5c6aa8f30a9ab261235c0b571
https://doi.org/10.1002/chin.200840205
https://doi.org/10.1002/chin.200840205
Autor:
Michael Butters, Alan Martin Birch, Peter W. Kenny, Pawel Siedlecki, Paul Robert Owen Whittamore, Jennifer Whitehouse, Ludovic Otterbein, Matthew S. Addie, Andrew Pannifer, Melvyn J. Taylor, Paul M. Murray, Linda Godfrey, David Whalley, Andy Stocker, Jeremy S. Parker, Andrew David Morley, Nikos G. Oikonomakos, Kristy Readman, Linda A. Townsend, Stuart Norman Lile Bennett, Paul Schofield
Publikováno v:
Bioorganic & Medicinal Chemistry Letters 16:21(Nov2006):5567-5571
Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described. Representative compounds have been shown to bind at the dimer in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a027fdd96a6fc9f365265c8ad7e44fb1
https://pubmed.ncbi.nlm.nih.gov/16945526
https://pubmed.ncbi.nlm.nih.gov/16945526
Autor:
Matthew S. Addie, Richard J. K. Taylor
Publikováno v:
e-EROS Encyclopedia of Reagents for Organic Synthesis
(C12H13IO4)n (MW 348.12) (polystyrene-supported derivative of (diacetoxyiodo)benzene used in the oxidation of aniline,1, 2 oxidation of hydroquinones,3-5 oxidative spirocyclization,4 phenolic oxidative coupling,6, 7 oxidation of alcohols,4, 8 oxidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b7a855438511686f7799e6c09a1901a
https://doi.org/10.1002/047084289x.rn00085
https://doi.org/10.1002/047084289x.rn00085
Autor:
Matthew S. Addie, Philippa Dudley, Ken Page, Sabina Cosulich, Linette Ruston, David Buttar, Gordon S. Currie, Clare Lane, Barry R. Davies, Claire Crafter, Johnson Paul David, Stuart E. Pearson, Richard W. A. Luke, Hannah Greenwood, Gillian M. Lamont, Ryan Greenwood, Matthew R. Box
Publikováno v:
Cancer Research. 71:4478-4478
AKT is a key node in the most frequently de-regulated signaling pathway in human cancer and has been shown to mediate resistance to a range of cytotoxic, anti-hormonal and targeted therapies. We decided to explore inhibitors of AKT as potential new a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e878c9eb863a7acc7fb17631ada7407
https://doi.org/10.1158/1538-7445.am2011-4478
https://doi.org/10.1158/1538-7445.am2011-4478