Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Matthew S Waitkus"'
Autor:
Seethalakshmi Hariharan, Benjamin T. Whitfield, Christopher J. Pirozzi, Matthew S. Waitkus, Michael C. Brown, Michelle L. Bowie, David M. Irvin, Kristen Roso, Rebecca Fuller, Janell Hostettler, Sharvari Dharmaiah, Emiley A. Gibson, Aaron Briley, Avani Mangoli, Casey Fraley, Mariah Shobande, Kevin Stevenson, Gao Zhang, Prit Benny Malgulwar, Hannah Roberts, Martin Roskoski, Ivan Spasojevic, Stephen T. Keir, Yiping He, Maria G. Castro, Jason T. Huse, David M. Ashley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH-mutant astrocytomas, have been implicated in dysfunctional imm
Externí odkaz:
https://doaj.org/article/93956c3a4d2c4721a96aa5db55f8df28
Autor:
Kevin J. Tu, Bill H. Diplas, Joshua A. Regal, Matthew S. Waitkus, Christopher J. Pirozzi, Zachary J. Reitman
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Enzymes with novel functions are needed to enable new organic synthesis techniques. Drawing inspiration from gain-of-function cancer mutations that functionally alter proteins and affect cellular metabolism, we developed METIS (Mutated Enzym
Externí odkaz:
https://doaj.org/article/94c7355530204fc0a288b6a401f0b9e5
Autor:
Cheng Xu, Heng Liu, Christopher J. Pirozzi, Lee H. Chen, Paula K. Greer, Bill H. Diplas, Liwei Zhang, Matthew S. Waitkus, Yiping He, Hai Yan
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-12 (2021)
Abstract Diffuse intrinsic pontine gliomas (DIPGs) are high-grade tumors of the brainstem that often occur in children, with a median overall survival of less than one year. Given the fact that DIPGs are resistant to chemotherapy and are not amenable
Externí odkaz:
https://doaj.org/article/e93641f3ec424b8eb9474f91fac10d50
Autor:
Lee H. Chen, Changcun Pan, Bill H. Diplas, Cheng Xu, Landon J. Hansen, Yuliang Wu, Xin Chen, Yibo Geng, Tao Sun, Yu Sun, Peng Zhang, Zhen Wu, Junting Zhang, Deling Li, Yang Zhang, Wenhao Wu, Yu Wang, Guangyu Li, Jie Yang, Xiaoyue Wang, Ce Xu, Sizhen Wang, Matthew S. Waitkus, Yiping He, Roger E. McLendon, David M. Ashley, Hai Yan, Liwei Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Brainstem gliomas are heterogenous in terms of clinical outcome and disease etiology. Here, the authors present a genetic and epigenetic landscape of brainstem gliomas, finding distinct epigenetic clusters associated with unique genetic and clinical
Externí odkaz:
https://doaj.org/article/20c3ed793a784a5b8bd512a9238d11e8
Autor:
Bill H. Diplas, Xujun He, Jacqueline A. Brosnan-Cashman, Heng Liu, Lee H. Chen, Zhaohui Wang, Casey J. Moure, Patrick J. Killela, Daniel B. Loriaux, Eric S. Lipp, Paula K. Greer, Rui Yang, Anthony J. Rizzo, Fausto J. Rodriguez, Allan H. Friedman, Henry S. Friedman, Sizhen Wang, Yiping He, Roger E. McLendon, Darell D. Bigner, Yuchen Jiao, Matthew S. Waitkus, Alan K. Meeker, Hai Yan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERT p WT-IDH WT glioblastoma). Here, the authors present a genetic landscape of TERTp WT-IDH WT glioblastoma, identifying
Externí odkaz:
https://doaj.org/article/dd48eac540f1490a9bb31a4f740711ca
Autor:
Seethalakshmi Hariharan, Benjamin T. Whitfield, Christopher J. Pirozzi, Matthew S. Waitkus, Michael C. Brown, Michelle L. Bowie, David M. Irvin, Kristen Roso, Rebecca Fuller, Janell Hostettler, Sharvari Dharmaiah, Emiley A. Gibson, Aaron Briley, Avani Mangoli, Casey Fraley, Mariah Shobande, Kevin Stevenson, Gao Zhang, Prit Benny Malgulwar, Hannah Roberts, Martin Roskoski, Ivan Spasojevic, Stephen T. Keir, Yiping He, Maria G. Castro, Jason T. Huse, David M. Ashley
Publikováno v:
bioRxiv
Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations inATRX, defining molecular alterations inIDH-mutant astrocytomas, have been implicated in dysfunctional immune signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ab341a30e4ab8c2358affae1c167fe
https://europepmc.org/articles/PMC10153255/
https://europepmc.org/articles/PMC10153255/
Autor:
Hai Yan, Yiping He, Darell D. Bigner, Roger E. McLendon, Ivan Spasojevic, Ping Fan, Cheryl B. Bock, Yu Wang, Jie Feng, Paula K. Greer, Lee H. Chen, Landon J. Hansen, Huishan Zhu, Catherine Y. Wang, Matthew S. Waitkus, Austin B. Carpenter, Christopher J. Pirozzi
Genes displaying more than 2-fold change among IDH1LSL:R132H/WT ad-GFP versus ad-Cre NSCs were selected for pathway analysis by DAVID.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0474a9e4bef24cd9485631bd44f80b72
https://doi.org/10.1158/1541-7786.22517364
https://doi.org/10.1158/1541-7786.22517364
Autor:
Hai Yan, Yiping He, Matthew S. Waitkus, Ivan Spasojevic, Zhaohui Wang, Christopher J. Pirozzi, Rui Yang, Lee H. Chen, Bill H. Diplas, Casey J. Moure
Differentially Methylated Probes Parental vs. Edited Clones or Parental vs. Unedited Clones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267db3d0d1df51bfdc550c6257af44ff
https://doi.org/10.1158/1541-7786.22513459.v1
https://doi.org/10.1158/1541-7786.22513459.v1
Autor:
Hai Yan, Yiping He, Darell D. Bigner, Roger E. McLendon, Ivan Spasojevic, Ping Fan, Cheryl B. Bock, Yu Wang, Jie Feng, Paula K. Greer, Lee H. Chen, Landon J. Hansen, Huishan Zhu, Catherine Y. Wang, Matthew S. Waitkus, Austin B. Carpenter, Christopher J. Pirozzi
Sequences of primers used for genotyping of animals and for q-RT-PCR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afe34e6d83cdc07de43702046ba43a7
https://doi.org/10.1158/1541-7786.22517370.v1
https://doi.org/10.1158/1541-7786.22517370.v1
Autor:
Hai Yan, Yiping He, Matthew S. Waitkus, Ivan Spasojevic, Zhaohui Wang, Christopher J. Pirozzi, Rui Yang, Lee H. Chen, Bill H. Diplas, Casey J. Moure
Conummee Copy Number Calls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6349ec79b13cd5b5556977db980e8004
https://doi.org/10.1158/1541-7786.22513465
https://doi.org/10.1158/1541-7786.22513465