Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Matthew S Rich"'
1
Akademický článek
CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles
Autor: Brian D Mueller, Sean A Merrill, Shigeki Watanabe, Ping Liu, Longgang Niu, Anish Singh, Pablo Maldonado-Catala, Alex Cherry, Matthew S Rich, Malan Silva, Andres Villu Maricq, Zhao-Wen Wang, Erik M Jorgensen
Publikováno v: eLife, Vol 12 (2023)
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter. Presynaptic output is a function of the density of calcium channels, the dynami
Externí odkaz: https://doaj.org/article/aff5d801f72a4f8aba271286f81e70b1
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2
Akademický článek
High-efficiency CRISPR gene editing in C. elegans using Cas9 integrated into the genome.
Autor: Matthew L Schwartz, M Wayne Davis, Matthew S Rich, Erik M Jorgensen
Publikováno v: PLoS Genetics, Vol 17, Iss 11, p e1009755 (2021)
Gene editing in C. elegans using plasmid-based CRISPR reagents requires microinjection of many animals to produce a single edit. Germline silencing of plasmid-borne Cas9 is a major cause of inefficient editing. Here, we present a set of C. elegans st
Externí odkaz: https://doaj.org/article/777ecedabc114ade999538b172ce2a3a
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3
CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles
Autor: Sean A Merrill, Brian D Mueller, Shigeki Watanabe, Ping Liu, Longgang Niu, Anish Singh, Pablo Maldonado-Catala, Alex Cherry, Matthew S Rich, Malan Silva, Andres Villu Maricq, Zhao-Wen Wang, Erik M Jorgensen
Publikováno v: eLife. 12
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter. Presynaptic output is a function of the density of calcium channels, the dynami
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7191531d374219f8d5cf7defa1e52c5
https://doi.org/10.7554/elife.81407
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6
No evidence that synonymous mutations in yeast genes are mostly deleterious
Autor: Leonid Kruglyak, Andreas Beyer, Joshua S. Bloom, Jan Grossbach, Tami D. Lieberman, Christopher P. Mancuso, Matthew S. Rich, Gavin Sherlock, Erik van Nimwegen, Craig D. Kaplan
In a recent paper1, Shen et al. reported that most mutations in the coding regions of 21 yeast genes were strongly deleterious, and that the distributions of fitness effects were similar for synonymous and nonsynonymous mutations. Taken at face value
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::401171fb4d4319bdc77f78dc2f8bdb69
https://doi.org/10.1101/2022.07.14.500130
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7
Engineered Biosensors from Dimeric Ligand-Binding Domains
Autor: David Baker, Benjamin W Jester, Matthew S. Rich, Christine E. Tinberg, Stanley Fields
Publikováno v: ACS Synthetic Biology. 7:2457-2467
Biosensors are important components of many synthetic biology and metabolic engineering applications. Here, we report a second generation of Saccharomyces cerevisiae digoxigenin and progesterone biosensors based on destabilized dimeric ligand-binding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0151fa82792a1c42818e5e59b97c7926
https://doi.org/10.1021/acssynbio.8b00242
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8
A Massively Parallel Fluorescence Assay to Characterize the Effects of Synonymous Mutations on TP53 Expression
Autor: Geetha Bhagavatula, Stanley Fields, Matthew S. Rich, David L. Young, Maximillian Marin
Publikováno v: Molecular Cancer Research. 15:1301-1307
Although synonymous mutations can affect gene expression, they have generally not been considered in genomic studies that focus on mutations that increase the risk of cancer. However, mounting evidence implicates some synonymous mutations as driver m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6725d4fd25ba6d7682bc6276db256fbe
https://doi.org/10.1158/1541-7786.mcr-17-0245
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9
Comprehensive Analysis of the SUL1 Promoter of Saccharomyces cerevisiae
Autor: Alan F. Rubin, Stanley Fields, Monica R. Sanchez, Matthew S. Rich, Giang T. Ong, Nozomu Yachie, Maitreya J. Dunham, Celia Payen
Publikováno v: Genetics. 203:191-202
In the yeast Saccharomyces cerevisiae, beneficial mutations selected during sulfate-limited growth are typically amplifications of the SUL1 gene, which encodes the high-affinity sulfate transporter, resulting in fitness increases of >35% . Cis-regula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ccfca1a16c79e9207a124dbb85defbf
https://doi.org/10.1534/genetics.116.188037
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10
The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes
Autor: Natasha Pashkova, Stanley C. Winistorfer, Robert C. Piper, Lokesh Gakhar, Maitreya J. Dunham, Liping Yu, Matthew S. Rich, Anna B. Sunshine
Publikováno v: Developmental Cell. 25(5):520-533
SummarySorting of ubiquitinated membrane proteins into lumenal vesicles of multivesicular bodies is mediated by the Endosomal Sorting Complex Required for Transport (ESCRT) apparatus and accessory proteins such as Bro1, which recruits the deubiquitin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cf0667d928e9001cc2387c145009de
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