Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis.

Autor: Jessica H Chertow, Matthew S Alkaitis, Glenn Nardone, Allison K Ikeda, Aubrey J Cunnington, Joseph Okebe, Augustine O Ebonyi, Madi Njie, Simon Correa, Shamanthi Jayasooriya, Climent Casals-Pascual, Oliver Billker, David J Conway, Michael Walther, Hans Ackerman

Publikováno v: PLoS Pathogens, Vol 11, Iss 9, p e1005119 (2015)

Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeosta

Externí odkaz: https://doaj.org/article/6df109d8e2704dc1834e0a80da25a24b

Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain.

Autor: Matthew S Alkaitis, Carlos Solorzano, Russell P Landry, Daniele Piomelli, Joyce A DeLeo, E Alfonso Romero-Sandoval

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10891 (2010)

An alarming portion of patients develop persistent or chronic pain following surgical procedures, but the mechanisms underlying the transition from acute to chronic pain states are not fully understood. In general, endocannabinoids (ECBs) inhibit noc

Externí odkaz: https://doaj.org/article/9827bb5ea81a4be38bffbb8c85ac6b2c

Decreased Rate of Plasma Arginine Appearance in Murine Malaria May Explain Hypoargininemia in Children With Cerebral Malaria

Autor: Anthony F. Suffredini, Oliver Billker, Karl B. Seydel, Terrie E. Taylor, David J. Roberts, Jessica H. Chertow, Honghui Wang, Ian J. C. MacCormick, Matthew S. Alkaitis, Carol A. Rowley, Allison K. Ikeda, Hans Ackerman

Publikováno v: Journal of Infectious Diseases. 214:1840-1849

Plasmodium infection depletes arginine, the substrate for nitric oxide synthesis, and impairs endothelium-dependent vasodilation. Increased conversion of arginine to ornithine by parasites or host arginase is a proposed mechanism of arginine depletio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ac39d87cc078c19a351dce5993904f
https://doi.org/10.1093/infdis/jiw452

Resolution and quantification of arginine, monomethylarginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma using HPLC with internal calibration

Autor: Glenn Nardone, Matthew S. Alkaitis, Jessica H. Chertow, Hans Ackerman

Publikováno v: Biomedical Chromatography

NG,NG‐dimethyl‐l‐arginine (asymmetric dimethylarginine, ADMA),NG‐monomethyl‐l‐arginine (l‐NMMA) and NG,N G’‐dimethyl‐l‐arginine (symmetric dimethylarginine, SDMA) are released during hydrolysis of proteins containing methylated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac15bacd636332a22f4c28823362ba8e
https://doi.org/10.1002/bmc.3548

Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis

Autor: Climent Casals-Pascual, Allison K. Ikeda, Simon Correa, Glenn Nardone, Hans Ackerman, Shamanthi Jayasooriya, David J. Conway, Aubrey J. Cunnington, Oliver Billker, Matthew S. Alkaitis, Madi Njie, Augustine O. Ebonyi, Jessica H. Chertow, Joseph Okebe, Michael Walther

Publikováno v: PLoS Pathogens, Vol 11, Iss 9, p e1005119 (2015)
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
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PLoS Pathogens

Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeosta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a39718ec74c751dd637b5f831618568
https://doaj.org/article/6df109d8e2704dc1834e0a80da25a24b