Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthew Ryals"'
Autor:
Jake Gagnon, Lira Pi, Matthew Ryals, Qingwen Wan, Wenxing Hu, Zhengyu Ouyang, Baohong Zhang, Kejie Li
Publikováno v:
Life, Vol 12, Iss 6, p 850 (2022)
To guide analysts to select the right tool and parameters in differential gene expression analyses of single-cell RNA sequencing (scRNA-seq) data, we developed a novel simulator that recapitulates the data characteristics of real scRNA-seq datasets w
Externí odkaz:
https://doaj.org/article/c154c563ce07478f9cfe8b1033529622
Autor:
Matthew Ryals, Robert J. Morell, Daniel Martin, Erich T. Boger, Patricia Wu, David W. Raible, Lisa L. Cunningham
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Mechanosensory hair cells of the inner ear transduce auditory and vestibular sensory input. Hair cells are susceptible to death from a variety of stressors, including treatment with therapeutic drugs that have ototoxic side effects. There is a need f
Externí odkaz:
https://doaj.org/article/8768a529d8e7418aabe65310ea6eb6d2
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186001 (2017)
Ototoxicity is a significant side effect of a number of drugs, including the aminoglycoside antibiotics and platinum-based chemotherapeutic agents that are used to treat life-threatening illnesses. Although much progress has been made, the mechanisms
Externí odkaz:
https://doaj.org/article/d41a7cf9593b462f87e1f4fa7c84a664
Autor:
Michael D Nguyen, Scott T Lee, Ashley E Ross, Matthew Ryals, Vishesh I Choudhry, B Jill Venton
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87165 (2014)
Adenosine is a neuroprotective agent that inhibits neuronal activity and modulates neurotransmission. Previous research has shown adenosine gradually accumulates during pathologies such as stroke and regulates neurotransmission on the minute-to-hour
Externí odkaz:
https://doaj.org/article/9fe83c92b2f74212bd1fbb3b6b52ea2a
Autor:
Peter E. Lipsky, Sarah E Heuer, Matthew Ryals, Amrie C. Grammer, Rob D Robl, Michelle D. Catalina, Laurie S. Davis, Bernard Lauwerys, Sushma Madamanchi
Publikováno v:
Lupus. 25:1150-1170
Lupus patients are in need of modern drugs to treat specific manifestations of their disease effectively and safely. In the past half century, only one new treatment has been approved by the US Food and Drug Administration (FDA) for systemic lupus er
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f29fa5898182587bccb2b41cd2f8a9
https://doi.org/10.1177/0961203316657437
https://doi.org/10.1177/0961203316657437
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 10, p e0186001 (2017)
PLoS ONE, Vol 12, Iss 10, p e0186001 (2017)
Ototoxicity is a significant side effect of a number of drugs, including the aminoglycoside antibiotics and platinum-based chemotherapeutic agents that are used to treat life-threatening illnesses. Although much progress has been made, the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa0dae09758f5667a9c974fc7966e2c
https://pubmed.ncbi.nlm.nih.gov/29049311
https://pubmed.ncbi.nlm.nih.gov/29049311
Systemic lupus erythematosus (SLE) is a complex and heterogeneous disease with few approved therapies. Drug development for SLE has been historically unsuccessful, with numerous failed clinical trials, and the approval of only a single new agent in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b29f972f647c70513b2ecfb335709bcd
https://doi.org/10.1016/b978-0-12-801917-7.00066-8
https://doi.org/10.1016/b978-0-12-801917-7.00066-8
Publikováno v:
Pharmacology Research & Perspectives
Adenosine is a neuromodulator that regulates neurotransmission in the brain and central nervous system. Recently, spontaneous adenosine release that is cleared in 3–4 sec was discovered in mouse spinal cord slices and anesthetized rat brains. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e0450a9a16b7fc7f54c66915ba14aa
https://doi.org/10.1002/prp2.189
https://doi.org/10.1002/prp2.189
Autor:
Scott T. Lee, Matthew Ryals, Michael D. Nguyen, Ashley E. Ross, B. Jill Venton, Vishesh I. Choudhry
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87165 (2014)
PLoS ONE
PLoS ONE
Adenosine is a neuroprotective agent that inhibits neuronal activity and modulates neurotransmission. Previous research has shown adenosine gradually accumulates during pathologies such as stroke and regulates neurotransmission on the minute-to-hour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6456161027b26e0c1af73fec403045ed
http://europepmc.org/articles/PMC3907895?pdf=render
http://europepmc.org/articles/PMC3907895?pdf=render
Autor:
Matthew Ryals, Soumen Roy, Tracy S. Fitzgerald, Lisa L. Cunningham, Astrid Botty Van den Bruele
Therapeutic drugs with ototoxic side effects cause significant hearing loss for thousands of patients annually. Two major classes of ototoxic drugs are cisplatin and the aminoglycoside antibiotics, both of which are toxic to mechanosensory hair cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93e5d44b4868fcf996b7df5f42746d2
https://europepmc.org/articles/PMC3809804/
https://europepmc.org/articles/PMC3809804/