Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Matthew Riopel"'
Autor:
Matthew Riopel, Melanie Vassallo, Erik Ehinger, Jennifer Pattison, Karen Bowden, Holger Winkels, Maria Wilson, Ron de Jong, Sanjay Patel, Deepika Balakrishna, James Bilakovics, Andrea Fanjul, Artur Plonowski, Christopher J. Larson, Klaus Ley, Pedro Cabrales, Joseph L. Witztum, Jerrold M. Olefsky, Yun Sok Lee
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 89-101 (2019)
Objective: Atherosclerosis is a major cause of cardiovascular disease. Monocyte-endothelial cell interactions are partly mediated by expression of monocyte CX3CR1 and endothelial cell fractalkine (CX3CL1). Interrupting the interaction between this li
Externí odkaz:
https://doaj.org/article/9aa1e09a965d493391f4ff36b42d349a
Autor:
Matthew Riopel, Jae-Su Moon, Gautam K. Bandyopadhyay, Seohee You, Kevin Lam, Xiao Liu, Tatiana Kisseleva, David Brenner, Yun Sok Lee
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101039- (2020)
Objective: Recent evidence indicates that inhibition of prolyl hydroxylase domain (PHD) proteins can exert beneficial effects to improve metabolic abnormalities in mice and humans. However, the underlying mechanisms are not clearly understood. This s
Externí odkaz:
https://doaj.org/article/06c284378d004c56b6f14b5961bc43b3
Publikováno v:
Diabetes, vol 71, iss 7
Diabetes
Diabetes
In obesity, increased mitochondrial metabolism with the accumulation of oxidative stress leads to mitochondrial damage and β-cell dysfunction. In particular, β-cells express antioxidant enzymes at relatively low levels and are highly vulnerable to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8a624d97f032b89613550d5c9c12e1
https://escholarship.org/uc/item/0kz0c5dw
https://escholarship.org/uc/item/0kz0c5dw
In obesity, increased mitochondrial metabolism with the accumulation of oxidative stress leads to mitochondrial damage and beta cell dysfunction. In particular, beta cells express anti-oxidant enzymes at relatively low levels and are highly vulnerabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485c525235e6e10d31bf5cdb1184ee43
https://doi.org/10.2337/figshare.19607331
https://doi.org/10.2337/figshare.19607331
Autor:
Holger Winkels, Karen Bowden, Sanjay Patel, Jerrold M. Olefsky, Jennifer Pattison, Artur Plonowski, Klaus Ley, Andrea Fanjul, Matthew Riopel, Yun Sok Lee, Melanie Vassallo, Maria Wilson, James Bilakovics, Pedro Cabrales, Deepika Balakrishna, Erik Ehinger, Ron de Jong, Christopher J. Larson, Joseph L. Witztum
Publikováno v:
Molecular Metabolism, Vol 20, Iss, Pp 89-101 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Atherosclerosis is a major cause of cardiovascular disease. Monocyte-endothelial cell interactions are partly mediated by expression of monocyte CX3CR1 and endothelial cell fractalkine (CX3CL1). Interrupting the interaction between this lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3eeb9bacbcd694ebba9edfa0888ac2
https://doi.org/10.1016/j.molmet.2018.11.011
https://doi.org/10.1016/j.molmet.2018.11.011
Autor:
Gautam Bandyopadhyay, Jae-Su Moon, Tatiana Kisseleva, Matthew Riopel, Yun Sok Lee, David A. Brenner, Xiao Liu, Seohee You, Kevin Lam
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 41, Iss, Pp 101039-(2020)
Molecular Metabolism, Vol 41, Iss, Pp 101039-(2020)
Objective Recent evidence indicates that inhibition of prolyl hydroxylase domain (PHD) proteins can exert beneficial effects to improve metabolic abnormalities in mice and humans. However, the underlying mechanisms are not clearly understood. This st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c824dd051cd1fa4ab56ab0c0cb5d7e8a
https://escholarship.org/uc/item/6855g2w5
https://escholarship.org/uc/item/6855g2w5
Autor:
Gautam Bandyopadhyay, Joshua Wollam, Revathy Sampath-Kumar, Matthew Riopel, Da Young Oh, Roi Isaac, Jerrold M. Olefsky, Denise E. Lackey, Dalila El Ouarrat, Jong Bae Seo, Yun Sok Lee
Publikováno v:
Cell metabolism, vol 31, iss 1
Summary Insulin resistance is a major factor in obesity-linked type 2 diabetes. PPARγ is a master regulator of adipogenesis, and small molecule agonists, termed thiazolidinediones, are potent therapeutic insulin sensitizers. Here, we studied the rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c672e9d63ffb002037fd9ce51c6b9833
https://escholarship.org/uc/item/0gv7h5s9
https://escholarship.org/uc/item/0gv7h5s9
Autor:
Anne N. Murphy, Jin Young Huh, Pedro Cabrales, Jerrold M. Olefsky, Matthew Riopel, Gordon I. Smith, Aleksander Andreyev, Jong Bae Seo, Gautam Bandyopadhyay, Yun Sok Lee, Scott C. Beeman, Samuel Klein
Publikováno v:
Nature metabolism, vol 1, iss 1
Decreased adipose tissue oxygen tension and increased HIF-1α expression can trigger adipose tissue inflammation and dysfunction in obesity. Our current understanding of obesity-associated decreased adipose tissue oxygen tension is mainly focused on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c745c2bb8cb39c6a9e7da7d69699dc
https://doi.org/10.1038/s42255-018-0003-x
https://doi.org/10.1038/s42255-018-0003-x
Publikováno v:
Oncotarget
Paediatrics Publications
Paediatrics Publications
// Jason Peart 1, 2 , Jinming Li 1, 3 , Hojun Lee 1, 3 , Matthew Riopel 1 , Zhi-Chao Feng 1 and Rennian Wang 1, 3 1 Children's Health Research Institute, London, Ontario, N6C 2V5, Canada 2 Department of Pathology, University of Western Ontario, Londo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f865976cc86e61dd870eb55921faf9eb
https://doi.org/10.18632/oncotarget.17969
https://doi.org/10.18632/oncotarget.17969
Autor:
Jong Bae, Seo, Matthew, Riopel, Pedro, Cabrales, Jin Young, Huh, Guatam K, Bandyopadhyay, Alexander Yu, Andreyev, Anne N, Murphy, Scott C, Beeman, Gordon I, Smith, Samuel, Klein, Yun Sok, Lee, Jerrold M, Olefsky
Publikováno v:
Nature metabolism
Decreased adipose tissue oxygen tension and increased HIF-1α expression can trigger adipose tissue inflammation and dysfunction in obesity. Our current understanding of obesity-associated decreased adipose tissue oxygen tension is mainly focused on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8c2d47f236e42b0948e660120be4b14
https://pubmed.ncbi.nlm.nih.gov/31528845
https://pubmed.ncbi.nlm.nih.gov/31528845