Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Matthew Rankin"'
Autor:
Lili Guo, Seunghun Paul Lee, George Ho, Lisa Norquay, Ivona Bakaj, Bin Zhu, Matthew Rankin, Jack Kauffman, Mark J. Macielag, Xuqing Zhang
Publikováno v:
ACS Med Chem Lett
[Image: see text] A novel series of pyridones were discovered as potent EP3 antagonists. Optimization guided by EP3 binding and functional assays as well as by eADME and PK profiling led to multiple compounds with good physical properties, excellent
Autor:
Bin Zhu, Xuqing Zhang, Lili Guo, Matthew Rankin, Ivona Bakaj, George Ho, Seunghun P. Lee, Lisa Norquay, Mark Macielag
Publikováno v:
ACS Med Chem Lett
[Image: see text] A novel series of 7-alkylidenyltetrahydroindazole-based acylsulfonamides were discovered as potent EP3 antagonists. The initial lead compound 7 exhibited potent in vitro EP3 inhibitory activity and good selectivity against other EP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344f2c288be9c0bded62ef975efb184d
https://europepmc.org/articles/PMC8762748/
https://europepmc.org/articles/PMC8762748/
Autor:
Haojia Wu, Romer Gonzalez Villalobos, Xiang Yao, Dermot Reilly, Tao Chen, Matthew Rankin, Eugene Myshkin, Matthew D. Breyer, Benjamin D. Humphreys
Publikováno v:
Cell Metab
Diabetic kidney disease (DKD) occurs in ∼40% of patients with diabetes and causes kidney failure, cardiovascular disease, and premature death. We analyzed the response of a murine DKD model to five treatment regimens using single-cell RNA sequencin
Autor:
June Zhi Xu, James Littrell, Seunghun Paul Lee, Guozhang Xu, Matthew Rankin, Jenson Qi, Ivona Bakaj, Alessandro Pocai
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinology
Frontiers in Endocrinology
The glucagon-like peptide-1 receptor (GLP-1R) is a G-protein-coupled receptor (GPCR) whose activation results in suppression of food intake and improvement of glucose metabolism. Several receptor interacting proteins regulate the signaling of GLP-1R
Autor:
Lisa Norquay, Bin Zhu, Mark J. Macielag, Matthew Rankin, Jack Kauffman, Xuqing Zhang, Seunghun Paul Lee, Ivona Bakaj, George Ho, Lili Guo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 47:128232
Autor:
Seunghun Paul Lee, George Ho, Lisa Norquay, Mark J. Macielag, Xuqing Zhang, Jack Kauffman, Lili Guo, Matthew Rankin, Bin Zhu, Ivona Bakaj
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 47:128172
A novel series of pyridone-based EP3 receptor antagonists was optimized for good physical properties and oral bioavailability in rodents. The lead compounds 3h, 3l and 4d displayed good in vitro profiles, moderate to good metabolic stability and good
Autor:
Matthew Rankin
Publikováno v:
Mens: Revue d'histoire intellectuelle de l'Amérique française. 6:135
Autor:
Matthew Rankin, Christian Bérubé
Publikováno v:
Mens: Revue d'histoire intellectuelle de l'Amérique française. 4:149
Autor:
Craig, Matthew Rankin
Publikováno v:
Theses and Dissertations.
In metabolic acidosis, the early increase in PEPCK mRNA and enzyme protein content contributes to the accelerated rates of ammonium and glucose formation. In situ hybridization demonstrated that expression of PEPCK was confined to medullary rays of r