Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Matthew Rajcula"'
Autor:
Virginia Smith Shapiro, Haidong Dong, Khashayarsha Khazaie, Xin Liu, Shaylene McCue, Matthew Rajcula, Michael J. Shapiro, Sydney B. Crotts, David J. Friedman
Many tumors exhibit increased incorporation of sialic acids into cell-surface glycans, which impact the tumor microenvironment. Sialic acid immunoglobulin-like lectins (Siglec) are receptors that recognize sialic acids and modulate immune responses,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812fed0ee91f24fd254196cea5b5055e
https://doi.org/10.1158/2326-6066.c.6550544
https://doi.org/10.1158/2326-6066.c.6550544
Autor:
Virginia Smith Shapiro, Haidong Dong, Khashayarsha Khazaie, Xin Liu, Shaylene McCue, Matthew Rajcula, Michael J. Shapiro, Sydney B. Crotts, David J. Friedman
Supplementary Tables S1-S2 and Supplementary Figures S1-S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d97fe1888db2bdca5747aa72edc7411
https://doi.org/10.1158/2326-6066.22544138
https://doi.org/10.1158/2326-6066.22544138
Autor:
David J. Friedman, Monika Kizerwetter, Paul Belmonte, Matthew Rajcula, Keith Theodore, Hyun Se Kim Lee, Michael J. Shapiro, Haidong Dong, Virginia Smith Shapiro
Publikováno v:
The Journal of Immunology. 208:1845-1850
Inhibitory receptors have a critical role in the regulation of immunity. Siglecs are a family of primarily inhibitory receptors expressed by immune cells that recognize specific sialic acid modifications on cell surface glycans. Many tumors have incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::804592450ef1595bd2c2ff048786be02
https://doi.org/10.4049/jimmunol.2101165
https://doi.org/10.4049/jimmunol.2101165
Autor:
Brandon Lee Maniaci, David Friedman, Sydney Crotts, Matthew Rajcula, Keith Theodore, Hyun Se Kim Lee, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 208:61.02-61.02
The lifetime risk for colorectal cancer in the United States is approximately 4%. Individuals with Inflammatory Bowel Disease, including Ulcerative Colitis and Crohn’s Disease, have a substantially increased risk of developing colorectal cancer. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bf11856bb934a9d4d1954d95a604a8b
https://doi.org/10.4049/jimmunol.208.supp.61.02
https://doi.org/10.4049/jimmunol.208.supp.61.02
Autor:
Sydney B Crotts, Regina Antonetti, Michael J Shapiro, Matthew Rajcula, Keith Theodore, Hyun Se Kim Lee, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 208:103.09-103.09
Inflammatory bowel disorders (IBD) including ulcerative colitis (UC) and Crohn’s disease (CD) affect between 1–3 million people in the United States with prevalence on the rise. Patients present with symptoms including diarrhea, abdominal cramps,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cf45bb4193a565617774b28d2c9debf
https://doi.org/10.4049/jimmunol.208.supp.103.09
https://doi.org/10.4049/jimmunol.208.supp.103.09
Autor:
Michael Jonathan Lehrke, Michael J Shapiro, Matthew Rajcula, Keith Theodore, Hyun Se Kim Lee, Virginia Smith Shapiro
Publikováno v:
The Journal of Immunology. 208:107.15-107.15
Iron-sulfur (Fe-S) clusters are cofactors essential for the activity of numerous enzymes including DNA polymerases, helicases, and glycosylases. They are synthesized in the mitochondria as Fe-S intermediates and are exported to the cytoplasm for matu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc6d6e0de1ca17acc2f77b7f60ece22
https://doi.org/10.4049/jimmunol.208.supp.107.15
https://doi.org/10.4049/jimmunol.208.supp.107.15
Autor:
Justin Choe, Paul Belmonte, Matthew Rajcula, Keith Theodore, Hyun Se Kim Lee, Michael J Shapiro, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 208:174.09-174.09
In this study, we harnessed immunomodulatory Siglec-sialic acid interactions to mitigate autoimmune rejection of beta cells in Type 1 Diabetes (T1D). Mice engineered to express the sialyltransferase ST8Sia6 in beta cells (βST mice) were backcrossed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f2d5e54b8799e5dbed5e34097a21f16
https://doi.org/10.4049/jimmunol.208.supp.174.09
https://doi.org/10.4049/jimmunol.208.supp.174.09
Autor:
Sydney B Crotts, David J Friedman, Michael J Shapiro, Matthew Rajcula, Virginia Smith Shapiro
Publikováno v:
The Journal of Immunology. 206:60.15-60.15
Inflammatory bowel disorders (IBD), including Crohn’s disease and colitis, have a prevalence between 10–20%. IBD patients experience a reduced quality of life due to symptoms such as diarrhea, abdominal cramps, anal bleeding. The exact etiology o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80ad1dc03fb2313733a326d0f7768c6e
https://doi.org/10.4049/jimmunol.206.supp.60.15
https://doi.org/10.4049/jimmunol.206.supp.60.15
Autor:
Drew Nicholas Wilfahrt, Rachael Philips, Monika Kizerwetter, Jyoti K Lama, Matthew Rajcula, Madeleine Kennedy, Virginia Smith Shapiro
Publikováno v:
The Journal of Immunology. 206:24.15-24.15
After activation, CD4+ T cells undergo metabolic modifications in order to orchestrate successful immune responses. In particular, naïve T cells shift to a more glycolysis-heavy metabolic program that produces the necessary metabolites for growth, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a1e4ba98cf969ac79a16dc6a65ed524
https://doi.org/10.4049/jimmunol.206.supp.24.15
https://doi.org/10.4049/jimmunol.206.supp.24.15
Autor:
David J Friedman, Sydney B Crotts, Michael J Shapiro, Matthew Rajcula, Shaylene McCue, Khashayarsha Khazaie, Haidong Dong, Virginia Smith Shapiro
Publikováno v:
The Journal of Immunology. 206:56.14-56.14
Checkpoint blockade has improved patient outcome through reinvigorating T cells against cancer. Despite this success, many patients don’t respond, leaving them with few options. Tumors utilize many immunosuppressive mechanisms, including altering t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c1b234ea0b4cb0227ef8ee89f86de4
https://doi.org/10.4049/jimmunol.206.supp.56.14
https://doi.org/10.4049/jimmunol.206.supp.56.14