Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Matthew R. Wright"'
Publikováno v:
Drugs in R&D, Vol 24, Iss 2, Pp 155-167 (2024)
Abstract Background and Objectives Despite significant progress in biomedical research, the rate of success in oncology drug development remains inferior to that of other therapeutic fields. Mechanistic models provide comprehensive understanding of t
Externí odkaz:
https://doaj.org/article/edd67a37d356415091a99db705d813f0
Autor:
Yuan Chen, Fang Ma, Nicholas S. Jones, Kenta Yoshida, Po‐Chang Chiang, Matthew R. Durk, Matthew R. Wright, Jin Yan Jin, Leslie W. Chinn
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 6, Pp 332-341 (2020)
Fenebrutinib is a CYP3A substrate and time‐dependent inhibitor, as well as a BCRP and OATP1B transporter inhibitor in vitro. Physiologically‐based pharmacokinetic (PBPK) modeling strategies with the ultimate goal of understanding complex drug‐d
Externí odkaz:
https://doaj.org/article/4b03517de89446c89515dc196f2449a5
Autor:
Marc Kschonsak, Christine C Jao, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S Dragovich, Matthew Volgraf, Matthew R Wright, Jian Payandeh, Claudio Ciferri, John C Tellis
Publikováno v:
eLife, Vol 12 (2023)
The voltage-gated sodium (NaV) channel NaV1.7 has been identified as a potential novel analgesic target due to its involvement in human pain syndromes. However, clinically available NaV channel-blocking drugs are not selective among the nine NaV chan
Externí odkaz:
https://doaj.org/article/1b1793fee7d349608601029e46d0c8cd
Publikováno v:
Drug Metabolism and Disposition. 50:1170-1181
Predicting human pharmacokinetics (PK) during the drug discovery phase is valuable to assess doses required to reach therapeutic exposures. For orally administered compounds, however, this can be especially difficult, since the absorption process is
Publikováno v:
The Journals of Gerontology: Series B.
Objectives The share of adults cohabiting at later ages has risen in the past few decades, though little is known about income pooling among midlife cohabitors. Cohabitation could be an attractive option because partners may be able to preserve their
Autor:
Christine C Jao, Marc Kschonsak, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S Dragovich, Matthew Volgraf, Matthew R Wright, Jian Payandeh, Claudio Ciferri, John C Tellis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd282fdd94d6f54f454fbf1d90a6ee32
https://doi.org/10.7554/elife.84151.sa2
https://doi.org/10.7554/elife.84151.sa2
Autor:
Marc Kschonsak, Christine C. Jao, Christopher P. Arthur, Alexis L. Rohou, Philippe Bergeron, Daniel Ortwine, Steven J. McKerrall, David H. Hackos, Lunbin Deng, Jun Chen, Peter S. Dragovich, Matthew Volgraf, Matthew R. Wright, Jian Payandeh, Claudio Ciferri, John C. Tellis
The voltage-gated sodium (NaV) channel NaV1.7 has been identified as a potential novel pain target due to its striking human genetics. However, clinically available drugs (e.g. lidocaine, carbamazepine, etc.) are not selective among the nine NaV chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb81783c5e491a22f8ca88176067e13
https://doi.org/10.1101/2022.11.10.515983
https://doi.org/10.1101/2022.11.10.515983
Publikováno v:
Journal of Family Issues. 44:538-559
Marital quality has been declining among recent cohorts, but whether this pattern characterizes middle-aged and older married adults is largely unknown. The doubling of the divorce rate among persons over the age of 50 years foretells poorer quality
Autor:
Matthew R, Wright
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2390
The improvement in the ability of the pharmaceutical industry to predict human pharmacokinetic behavior are attributable to major technological shifts from 1990 to the present day. The opportunity for the application of AI/ML based approaches in the
Publikováno v:
J Gerontol B Psychol Sci Soc Sci
Objectives Loneliness in later life is associated with poorer health and higher risk of mortality. Our study assesses whether gray divorced adults report higher levels of loneliness than the widowed and whether social support or repartnership offset