The role of endothelial cell attachment to elastic fibre molecules in the enhancement of monolayer formation and retention, and the inhibition of smooth muscle cell recruitment

Autor: Richard A. Black, Cay M. Kielty, Ann E. Canfield, Matthew R. Williamson, Adrian Shuttleworth

Publikováno v: Biomaterials. 28:5307-5318

The endothelium is an essential modulator of vascular tone and thrombogenicity and a critical barrier between the vessel wall and blood components. In tissue-engineered small-diameter vascular constructs, endothelial cell detachment in flow can lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c687da66197ccdacb0713855507f3390
https://doi.org/10.1016/j.biomaterials.2007.08.019

Gravity spun polycaprolactone fibres for soft tissue engineering: Interaction with fibroblasts and myoblasts in cell culture

Autor: Allan G.A. Coombes, Matthew R. Williamson, Eric F. Adams

Publikováno v: Biomaterials. 27:1019-1026

Poly(epsilon-caprolactone) (PCL) fibres were produced by wet spinning from solutions in acetone under low shear (gravity flow) conditions. As-spun PCL fibres exhibited a mean strength and stiffness of 7.9 MPa and 0.1 GPa, respectively and a rough, po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91c5da8612d6ead9d80e8878363a188
https://doi.org/10.1016/j.biomaterials.2005.06.018

Precipitation casting of polycaprolactone for applications in tissue engineering and drug delivery

Autor: Allan G.A. Coombes, Simone C. Rizzi, S. Downes, Matthew R. Williamson, W.A. Wallace, Jake E. Barralet

Publikováno v: Biomaterials. 25:315-325

Microporous materials have been produced by gradual precipitation from solutions of poly(epsilon-caprolactone) (PCL) in acetone induced by solvent extraction across a semi-permeable PCL membrane which is formed in situ at the polymer solution/non-sol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697b9a3bdcac71b73617190cce7bdcd5
https://doi.org/10.1016/s0142-9612(03)00535-0

Cell-matrix biology in vascular tissue engineering

Autor: Matthew R. Williamson, Daniel V. Bax, C. Adrian Shuttleworth, Cay M. Kielty, Simon Stephan, Stephen Ball, Amanda Lomas

Publikováno v: Stephan, S, Ball, S G, Williamson, M, Bax, D V, Lomas, A, Shuttleworth, C A & Kielty, C M 2006, ' Cell-matrix biology in vascular tissue engineering ', Journal of Anatomy, vol. 209, no. 4, pp. 495-502 . https://doi.org/10.1111/j.1469-7580.2006.00633.x

We are developing biocompatible small-calibre vascular substitutes based on polymeric scaffolds that incorporate cell-matrix signals to enhance vascular cell attachment and function. Our graft scaffold comprises an outer electrostatically spun porous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96ce46888e60faab78b02edb0da5400
https://europepmc.org/articles/PMC2100353/

PCL-PU composite vascular scaffold production for vascular tissue engineering: attachment, proliferation and bioactivity of human vascular endothelial cells

Autor: Matthew R. Williamson, Richard A. Black, Cay M. Kielty

Publikováno v: Biomaterials. 27(19)

A new compliant scaffold suitable for small-diameter vascular grafts has been developed that promotes strong attachment of endothelial cells. Composite scaffolds were produced by wet spinning polycaprolactone (PCL) fibres which form the luminal surfa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3aeb708d81ad85a8268f8c9e777554
https://pubmed.ncbi.nlm.nih.gov/16530824