Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Matthew R. Swiatnicki"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The E2F family of transcription factors is important for many cellular processes, from their canonical role in cell cycle regulation to other roles in angiogenesis and metastasis. Alteration of the Rb/E2F pathway occurs in various forms of c
Externí odkaz:
https://doaj.org/article/cd3d8c51cc584568b05e926126d6c529
Autor:
Matthew R Swiatnicki, Jonathan P Rennhack, Mylena M O Ortiz, Daniel P Hollern, Ashlee V Perry, Rachel Kubiak, Sarai M Riveria Riveria, Sandra O'Reilly, Eran R Andrechek
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010362 (2022)
The role of EGFR in lung cancer is well described with numerous activating mutations that result in phosphorylation and tyrosine kinase inhibitors that target EGFR. While the role of the EGFR kinase in non-small cell lung cancer (NSCLC) is appreciate
Externí odkaz:
https://doaj.org/article/803ec9957ab743e9ab0f4a7a00cdb9a8
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007135 (2018)
Human breast cancer has been characterized by extensive transcriptional heterogeneity, with dominant patterns reflected in the intrinsic subtypes. Mouse models of breast cancer also have heterogeneous transcriptomes and we noted that specific histolo
Externí odkaz:
https://doaj.org/article/783676e198304b68981bb11108122789
Autor:
S. O'Reilly, S. M. Riveria Riveria, Jonathan P. Rennhack, D. Hollern, A. V. Perry, R. Kubiak, Matthew R. Swiatnicki, Eran R. Andrechek
The role of EGFR in lung cancer is well described with numerous activating mutations that result in phosphorylation and tyrosine kinase inhibitors that target EGFR. While the role of the EGFR kinase in non-small cell lung cancer (NSCLC) is appreciate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e56705ae704878b755e9acb6c667b69c
https://doi.org/10.1101/2021.09.14.460311
https://doi.org/10.1101/2021.09.14.460311
Autor:
William J. Muller, Morag Park, Jonathan P. Rennhack, Dongmei Zuo, Harvey W. Smith, Jarey Wang, Alison Hirukawa, Thomas F. Westbrook, Kamilia Daldoul, Matthew R. Swiatnicki, Salendra Singh, Lyndsay Harris, Vinay Varadan, Cynthia Lavoie, Virginie Sanguin-Gendreau, Eran R. Andrechek
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 249-257.e8 (2019)
Summary: Monoclonal antibodies (mAbs) targeting the oncogenic receptor tyrosine kinase ERBB2/HER2, such as Trastuzumab, are the standard of care therapy for breast cancers driven by ERBB2 overexpression and activation. However, a substantial proporti
Autor:
Christina Ross, Karol Szczepanek, Matthew R. Swiatnicki, Sophia Y. Lunt, Yueqi Zhang, Eran R. Andrechek, Muthu Jayatissa, Caralynn Li, Martin P. Ogrodzinski, Briana To, William Hanrahan, Evan Bylett, Caleb Dulak, Kent W. Hunter, Jonathan P. Rennhack
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Mouse models have an essential role in cancer research, yet little is known about how various models resemble human cancer at a genomic level. Here, we complete whole genome sequencing and transcriptome profiling of two widely used mouse models of br
E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration
Autor:
Matthew R. Swiatnicki, Brooke C. Matson, Sean A. Misek, Jonathan P. Rennhack, Andrew McAuliff, Daniel P. Hollern, Eran R. Andrechek, Kathleen M. Caron, Kathleen A. Gallo
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
In prior work we demonstrated that loss of E2F transcription factors inhibits metastasis. Here we address the mechanisms for this phenotype and identify the E2F regulated genes that coordinate tumor cell metastasis. Transcriptomic profiling of E2F1 k
Autor:
Salendra Singh, Vasilios Papavasiliou, Catherine R. Dufour, Jane Beith, Ipshita Nandi, Eran R. Andrechek, Virginie Sanguin-Gendreau, Ewan K.A. Millar, Lyndsay Harris, Asier Unciti-Broceta, Mark Basik, Harvey W. Smith, Sandra A O'Toole, Carolin Temps, Vincent van Hoef, Vinay Varadan, Vincent Giguère, Cynthia Lavoie, Matthew R. Swiatnicki, Ola Larsson, Paul Savage, Alison Hirukawa, Kristofferson Tandoc, Jonathan P. Rennhack, Christina I. Selinger, Matthew Leibovitch, Neil O. Carragher, Ana Cristina Vargas Calderon, Ivan Topisirovic, Dongmei Zuo, Morag Park, Caroline Cooper, William J. Muller
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Dysregulation of histone modifications promotes carcinogenesis by altering transcription. Breast cancers frequently overexpress the histone methyltransferase EZH2, the catalytic subunit of Polycomb Repressor Complex 2 (PRC2). However, the role of EZH
Publikováno v:
Journal of Thoracic Oncology. 15:S20
Publikováno v:
Journal of mammary gland biology and neoplasia. 24(3)
Human breast cancer is a heterogeneous disease with numerous subtypes that have been defined through immunohistological, histological, and gene expression patterns. The diversity of breast cancer has made the study of its various underlying causes co