Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Matthew R. Sullivan"'
Autor:
Matthew R. Sullivan, Rachel P. White, Dashnamoorthy Ravi, Ninad Kanetkar, Ilana Berger Fridman, Adam Ekenseair, Andrew M. Evens, Tania Konry
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract For over two decades, Rituximab and CHOP combination treatment (rCHOP) has remained the standard treatment approach for diffuse large B-cell lymphoma (DLBCL). Despite numerous clinical trials exploring treatment alternatives, few options hav
Externí odkaz:
https://doaj.org/article/ac4a1e2186c6414b8e7f1185567e9e33
Autor:
Matthew R. Sullivan, James C Kostas, Alexander R. Ivanov, Smadar Cohen, Michal Gregus, Somak Ray, Ilana Berger Fridman, Tania Konry
Publikováno v:
Acta Biomater
Cancer is driven by both genetic aberrations in the tumor cells and fundamental changes in the tumor microenvironment (TME). These changes offer potential targets for novel therapeutics, yet lack of in vitro 3D models recapitulating this complex micr
Publikováno v:
Applied Thermal Engineering. 229:120578
Autor:
Matthew G Dowgiallo, Krishna Aluri, Jeffrey N. Agar, Ninad S. Kanetkar, Amin Hossain, Adam K. Ekenseair, Matthew R. Sullivan, Brandon C Miller, Durgalakshmi Sivasankar, Tania Konry, Roman Manetsch
Publikováno v:
Bioconjugate Chemistry. 32:584-594
We recently reported that cyclic thiosulfinates are cysteine selective cross-linkers that avoid the "dead-end" modifications that contribute to other cross-linkers' toxicity. In this study, we generalize the chemistry of cyclic thiosulfinates to that
Autor:
Matthew R. Sullivan, Saheli Sarkar, Seamus Mckenney, Giovanni Stefano Ugolini, Tania Konry, Evan Carlton Smith, Wenjing Kang
Publikováno v:
Cell Death and Disease, Vol 11, Iss 11, Pp 1-9 (2020)
The inhibition of the PD1/PDL1 pathway has led to remarkable clinical success for cancer treatment in some patients. Many, however, exhibit little to no response to this treatment. To increase the efficacy of PD1 inhibition, additional checkpoint inh
Autor:
John D. Chodera, Michael W. Chiu, Steven Murkli, Lyle Isaacs, John N. McNeill, Michael K. Gilson, Andrea Rizzi, Bruce C. Gibb, Matthew R. Sullivan, Wei Yao, David L. Mobley
Publikováno v:
Journal of Computer-Aided Molecular Design. 32:937-963
Accurately predicting the binding affinities of small organic molecules to biological macro-molecules can greatly accelerate drug discovery by reducing the number of compounds that must be synthesized to realize desired potency and selectivity goals.
Publikováno v:
The Journal of Physical Chemistry B. 122:1702-1713
The interactions between nonpolar surfaces and polarizable anions lie in a gray area between the hydrophobic and Hofmeister effects. To assess the affinity of these interactions, NMR and ITC were used to probe the thermodynamics of eight anions bindi
Autor:
Joshua A. Long, Thong Nguyen, Henry S. Ashbaugh, Bruce C. Gibb, J. Wesley Barnett, Matthew R. Sullivan, Dor Ben-Amotz, Du Tang
Publikováno v:
Nat Chem
There are many open questions regarding the hydration of solvent-exposed non-polar tracts and pockets in proteins. Although water is predicted to de-wet purely repulsive surfaces and evacuate crevices, the extent of de-wetting is unclear when ubiquit
Publikováno v:
Supramolecular chemistry. 31(3)
Although computer-aided drug design has greatly improved over time, its application in the pharmaceutical industry is still limited by the accuracy of association constant predictions. Towards improving this situation, the Statistical Assessment of t
Publikováno v:
Journal of Computer-Aided Molecular Design. 31:21-28
In participation of the fifth statistical assessment of modeling of proteins and ligands (SAMPL5), the strength of association of six guests (3-8) to two hosts (1 and 2) were measured by 1H NMR and ITC. Each host possessed a unique and well-defined b