Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Matthew R. Pratt"'
Publikováno v:
JACS Au, Vol 2, Iss 1, Pp 74-83 (2021)
Externí odkaz:
https://doaj.org/article/9c5677dc32b24cf08c4b648fe6109407
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101113- (2022)
Summary: O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant posttranslational modification involved in a wide range of signaling pathways, but its specific role in regulating biological processes remains unclear. This protocol describes approa
Externí odkaz:
https://doaj.org/article/7705d6936498457cb6b7ab8710abe63a
Autor:
Shuaijiang Jin, Roberto J. Brea, Andrew K. Rudd, Stuart P. Moon, Matthew R. Pratt, Neal K. Devaraj
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Sequestration of reactants in lipid vesicles is a strategy prevalent in biological systems to raise the rate and specificity of chemical reactions. Here, the authors show that micelle-assisted reactions facilitate native chemical ligation between a p
Externí odkaz:
https://doaj.org/article/d523faaf6776431fa7a2b80e8cddfeb5
Autor:
Shuaijiang Jin, Roberto J. Brea, Andrew K. Rudd, Stuart P. Moon, Matthew R. Pratt, Neal K. Devaraj
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22508-2
Externí odkaz:
https://doaj.org/article/ec3e440211dd48658ef588780b581bba
Autor:
Narek Darabedian, Bo Yang, Richie Ding, Giuliano Cutolo, Balyn W. Zaro, Christina M. Woo, Matthew R. Pratt
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Monosaccharide analogs bearing bioorthogonal functionalities, or metabolic chemical reporters (MCRs) of glycosylation, have been used for approximately two decades for the visualization and identification of different glycoproteins. More recently, pr
Externí odkaz:
https://doaj.org/article/9af1763064db4c8484cd82331fd5bd1c
Publikováno v:
Biomolecules, Vol 5, Iss 3, Pp 1210-1227 (2015)
α-Synuclein is the aggregation-prone protein associated with Parkinson’s disease (PD) and related neurodegenerative diseases. Complicating both its biological functions and toxic aggregation are a variety of posttranslational modifications. These
Externí odkaz:
https://doaj.org/article/31959b78c6de42eb9d845db3f687c2b6
Autor:
Saki Ichikawa, Hope A. Flaxman, Wenqing Xu, Nandini Vallavoju, Hannah C. Lloyd, Binyou Wang, Dacheng Shen, Matthew R. Pratt, Christina M. Woo
Publikováno v:
Nature
The ubiquitin E3 ligase substrate adapter cereblon (CRBN) is a target of thalidomide and lenalidomide(1), therapeutic agents used in the treatment of haematopoietic malignancies(2-4) and as ligands for targeted protein degradation(5-7). These agents
Autor:
Paul M. Levine, Timothy W. Craven, Xinting Li, Aaron T. Balana, Gregory H. Bird, Marina Godes, Patrick J. Salveson, Patrick W. Erickson, Mila Lamb, Maggie Ahlrichs, Michael Murphy, Cassandra Ogohara, Meerit Y. Said, Loren D. Walensky, Matthew R. Pratt, David Baker
Publikováno v:
ACS Chem Biol
Peptide and protein bioconjugation technologies have revolutionized our ability to site-specifically or chemoselectively install a variety of functional groups for applications in chemical biology and medicine, including the enhancement of bioavailab
Autor:
Nageswari Yarravarapu, Rohit Sai Reddy Konada, Narek Darabedian, Nichole J. Pedowitz, Soumya N. Krishnamurthy, Matthew R. Pratt, Jennifer J. Kohler
Publikováno v:
Bioconjug Chem
Glycan binding often mediates extracellular macromolecular recognition events. Accurate characterization of these binding interactions can be difficult because of dissociation and scrambling that occur during purification and analysis steps. Use of p
Autor:
Aaron T. Balana, Anne-Laure Mahul-Mellier, Binh A Nguyen, Mian Horvath, Afraah Javed, Eldon R. Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M.-Y. Lee, Kelvin C. Luk, Lorena Saelices, Hilal A. Lashuel, Matthew R. Pratt
Publikováno v:
bioRxiv
The process of amyloid fibril formation remains one of the primary targets for developing diagnostics and treatments for several neurodegenerative diseases (NDDs). Amyloid-forming proteins such α-Synuclein and Tau, which are implicated in the pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9a9ba932fcb45cc42feb6f11579b5d
https://doi.org/10.1101/2023.03.07.531573
https://doi.org/10.1101/2023.03.07.531573