Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Matthew R. Pawlus"'
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72358 (2013)
The HIF1- and HIF2-mediated transcriptional responses play critical roles in solid tumor progression. Despite significant similarities, including their binding to promoters of both HIF1 and HIF2 target genes, HIF1 and HIF2 proteins activate unique su
Externí odkaz:
https://doaj.org/article/e95e77da2ddf48d2bf5b4cfe3028e43e
Publikováno v:
Molecular Cancer Research. 12:728-741
Adrenomedullin (ADM) is important for tumor angiogenesis, tumor cell growth, and survival. Under normoxic conditions, the ADM gene was found to produce two alternative transcripts, a fully spliced transcript that produces AM and PAMP peptides and int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aaee8fa3bf21aaa0fda3550cac7ba8e
https://doi.org/10.1158/1541-7786.mcr-13-0607
https://doi.org/10.1158/1541-7786.mcr-13-0607
Autor:
Matthew R. Pawlus, Cheng-Jun Hu
Publikováno v:
Cellular Signalling. 25:1895-1903
Hypoxia is a prevalent attribute of the solid tumor microenvironment that promotes the expression of genes through posttranslational modifications and stabilization of alpha subunits (HIF1α and HIF2α) of hypoxia-inducible factors (HIFs). Despite si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a027fbf89b1255149ba80b50faea21bd
https://doi.org/10.1016/j.cellsig.2013.05.018
https://doi.org/10.1016/j.cellsig.2013.05.018
Autor:
Pinella Failla, Christelle Golzio, Nicholas Katsanis, Ed S. Lein, Kali Witherspoon, Heather C Mefford, Marco Fichera, Jill A. Rosenfeld, David G. Amaral, Jennifer Gerdts, Hilde Peeters, Janneke H M Schuurs-Hoeijmakers, Raphael Bernier, Carl Baker, Ludmila Francescatto, Serafino Buono, Corrado Romano, Brian J. O'Roak, Julia Rankin, Matthew R. Pawlus, Trygve E. Bakken, Bradley P. Coe, Anneke T. Vulto-van Silfhout, Bert B.A. de Vries, Randall T. Moon, Evan E. Eichler, Bo Xiong, Lisenka E.L.M. Vissers, Osnat Penn, Holly A.F. Stessman, Antonino Alberti, Jay Shendure, Paolo Bosco, Jean Steyaert
Publikováno v:
Cell, pp. 263-76
Cell, 263-76
STARTPAGE=263;ENDPAGE=76;ISSN=0092-8674;TITLE=Cell
Cell, 263-76
STARTPAGE=263;ENDPAGE=76;ISSN=0092-8674;TITLE=Cell
SummaryAutism spectrum disorder (ASD) is a heterogeneous disease in which efforts to define subtypes behaviorally have met with limited success. Hypothesizing that genetically based subtype identification may prove more productive, we resequenced the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0699737dab20e22ea8f442361cd8d217
https://doi.org/10.1016/j.cell.2014.06.017
https://doi.org/10.1016/j.cell.2014.06.017
While the functions of hypoxia-inducible factor 1α (HIF1α)/aryl hydrocarbon receptor nuclear translocator (ARNT) and HIF2α/ARNT (HIF2) proteins in activating hypoxia-inducible genes are well established, the role of other transcription factors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc00d1c23ab0c8db44a9e53c4a55a99
https://europepmc.org/articles/PMC3486188/
https://europepmc.org/articles/PMC3486188/
Autor:
Matthew R. Pawlus, John L. Magnani, Elihu H. Estey, Pamela S. Becker, Frederick R. Appelbaum, Randall T. Moon, Megan Othus, Siraj U. Haq, Sylvia Chien
Publikováno v:
Blood. 122:61-61
Background Adhesion within the bone marrow microenvironment enhances leukemia survival and chemoresistance. Both normal hematopoietic stem cells and cancer cells are known to express E-selectin ligands, and adhesion of colon carcinoma cells to E sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f29972de9941af1e2f6b89956db2bc6
https://doi.org/10.1182/blood.v122.21.61.61
https://doi.org/10.1182/blood.v122.21.61.61
Publikováno v:
Cancer Research. 71:2048-2048
Hypoxia inducible factor HIF1α, and in particular HIF2α have been shown to drive malignant progression by activation of angiogenesis, proliferation, anaerobic metabolism, and other processes that enable tumor cells to survive or to escape their O2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c94186988e4434b878592d67271add9
https://doi.org/10.1158/1538-7445.am2011-2048
https://doi.org/10.1158/1538-7445.am2011-2048