Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthew R. Locher"'
Autor:
Matthew R. Locher, Ying Ge, Yi-Chen Chen, Richard L. Moss, Nicole M. Lane, Takushi Kohmoto, Ying Peng, Lars Larsson, Serife Ayaz-Guner
Publikováno v:
Analytical Chemistry. 87:8399-8406
Actin is the major component of the cytoskeleton playing an essential role in the structure and motility of both muscle and non-muscle cells. It is highly conserved and encoded by a multigene family. α-cardiac actin (αCAA) and α-skeletal actin (α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e05320008f75607df306edced411cd8
https://doi.org/10.1021/acs.analchem.5b01745
https://doi.org/10.1021/acs.analchem.5b01745
Autor:
Tanya Bekyarova, Brett A. Colson, Daniel P. Fitzsimons, Richard L. Moss, Jitandrakumar R. Patel, Matthew R. Locher, Thomas C. Irving
Publikováno v:
The Journal of Physiology. 588:981-993
Phosphorylation of myosin regulatory light chain (RLC) by myosin light chain kinase (MLCK) and myosin binding protein-C (cMyBP-C) by protein kinase A (PKA) independently accelerate the kinetics of force development in ventricular myocardium. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91e2e15985511402d447d25c6188ec77
https://doi.org/10.1113/jphysiol.2009.183897
https://doi.org/10.1113/jphysiol.2009.183897
Autor:
Julian E. Stelzer, Matthew R. Locher, Maria V. Razumova, Jitandrakumar R. Patel, Holly S. Norman, Richard L. Moss
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 297:H247-H256
The ventricles of small mammals express mostly α-myosin heavy chain (α-MHC), a fast isoform, whereas the ventricles of large mammals, including humans, express ∼10% α-MHC on a predominately β-MHC (slow isoform) background. In failing human vent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f5ade930d73fa8c74e6b759157a53b
https://doi.org/10.1152/ajpheart.00922.2008
https://doi.org/10.1152/ajpheart.00922.2008
Publikováno v:
The Journal of Physiology. 579:161-173
The speed and force of myocardial contraction during systolic ejection is largely dependent on the intrinsic contractile properties of cardiac myocytes. As the myosin heavy chain (MHC) isoform of cardiac muscle is an important determinant of the cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc9f1be85d971d8c6cc8d1403129ff4a
https://doi.org/10.1113/jphysiol.2006.119719
https://doi.org/10.1113/jphysiol.2006.119719
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 300(3)
Myosin heavy chain (MHC) isoforms are principal determinants of work capacity in mammalian ventricular myocardium. The ventricles of large mammals including humans normally express ∼10% α-MHC on a predominantly β-MHC background, while in failing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686e9b6e4909c58731685745460157ca
https://pubmed.ncbi.nlm.nih.gov/21217059
https://pubmed.ncbi.nlm.nih.gov/21217059
Autor:
Thomas C. Irving, Matthew R. Locher, Patricia A. Powers, Tanya Bekyarova, Brett A. Colson, Carl W. Tong, Daniel P. Fitzsimons, Richard L. Moss
Publikováno v:
Biophysical Journal. 96(3)
Protein kinase A-mediated (PKA) phosphorylation of cardiac myosin binding protein-C (cMyBP-C) accelerates the kinetics of cross-bridge cycling and appears to relieve the tether-like constraint of myosin heads imposed by cMyBP-C (Colson et al., 2008,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29baf121fbabae31e3bc83b01a54cc0f
Autor:
Tanya Bekyarova, Daniel P. Fitzsimons, Brett A. Colson, Matthew R. Locher, Richard L. Moss, Thomas C. Irving
Publikováno v:
Circulation research. 103(3)
Protein kinase A–mediated (PKA) phosphorylation of cardiac myosin binding protein C (cMyBP-C) accelerates the kinetics of cross-bridge cycling and may relieve the tether-like constraint of myosin heads imposed by cMyBP-C. We favor a mechanism in wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caad274000e1c62f58003d2052980643
https://pubmed.ncbi.nlm.nih.gov/18599866
https://pubmed.ncbi.nlm.nih.gov/18599866
Publikováno v:
Journal of Molecular and Cellular Cardiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe862286cfac0d5ba9eee32313661d56
https://doi.org/10.1016/j.yjmcc.2007.03.845
https://doi.org/10.1016/j.yjmcc.2007.03.845
Autor:
Richard L. Moss, John C. Ralphe, Willem J. de Lange, Matthew R. Locher, Laura F. Hegge, Adrian C. Grimes
Publikováno v:
Biophysical Journal. 102:351a-352a
Congestive heart failure is a debilitating disease in which the principal pathology is impaired ventricular contractility leading to diminished cardiac output, and previous work indicates that reduced contractility is based in part on the ratio of my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d4b27dceaa2b48463522f751e5651b
https://doi.org/10.1016/j.bpj.2011.11.1926
https://doi.org/10.1016/j.bpj.2011.11.1926
Autor:
Nancy K. Sweitzer, Satoru Osaki, Richard L. Moss, Holly S. Norman, Matthew R. Locher, Takushi Kohmoto
Publikováno v:
Biophysical Journal. 98:716a
The ventricles of human myocardium normally express low levels of α myosin heavy chain (MHC) on a predominately β MHC background. However, in heart failure the distribution changes to ∼100% β MHC with virtually undetectable levels of α MHC, a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca1b257a6ece19664275f1ca8b90358
https://doi.org/10.1016/j.bpj.2009.12.3924
https://doi.org/10.1016/j.bpj.2009.12.3924