Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Matthew R. Kimbrell"'
Autor:
Clayton E. Mathews, Daniel J. Perry, Mark A. Atkinson, Andrew Muir, Anna V. Chernatynskaya, Jian-Wei Li, Jing Chen, Matthew R. Kimbrell, Richard J. Cassidy, Todd M. Brusko
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
T lymphocytes constitute a major effector cell population in autoimmune type 1 diabetes. Despite essential functions of mitochondria in regulating activation, proliferation, and apoptosis of T cells, little is known regarding T cell metabolism in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85837e41936157e1273fd7c4d045c57f
https://pubmed.ncbi.nlm.nih.gov/28883439
https://pubmed.ncbi.nlm.nih.gov/28883439
Autor:
Sunil A. David, Xinkun Wang, Hemamali J. Warshakoon, Subbalakshmi S. Malladi, Nikunj M. Shukla, Matthew R. Kimbrell, Jennifer D. Hood
Publikováno v:
Human Vaccines. 6:322-335
There is a pressing need for the development of novel, safe and effective adjuvants. The recent discovery and characterization of pathogen-associated molecular pattern (PAMP)-recognizing elements such as the Toll-like, NOD-like and RIG-like receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40373f926b0c3cb5c051284800e24b76
https://doi.org/10.4161/hv.6.4.10866
https://doi.org/10.4161/hv.6.4.10866
Protection from endotoxic shock by EVK-203, a novel alkylpolyamine sequestrant of lipopolysaccharide
Autor:
Thuan B. Nguyen, E. V. K. Suresh Kumar, Rajalakshmi Balakrishna, Sunil A. David, Matthew R. Kimbrell, Apurba Datta, Kelly A. Miller, Ashok Kumar Adisechan
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5694-5709
Lipopolysaccharides (LPS) play a key role in the pathogenesis of septic shock, a major cause of mortality in the critically ill patient. The only therapeutic option aimed at limiting downstream systemic inflammatory processes by targeting lipopolysac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a5bbe9498deba6aaa8b9f8010b1873
https://doi.org/10.1016/j.bmc.2007.06.015
https://doi.org/10.1016/j.bmc.2007.06.015
Autor:
Shravan Arora, Diptesh Sil, Apurba Datta, Matthew R. Kimbrell, Shannon Short, Sunil A. David, Jens R. Cromer, Anurupa Shrestha, Benjamin G. Abbo, Thuan B. Nguyen, Kelly A. Miller, Subbalakshmi S. Malladi, Ashok Kumar Adisechan, Rajalakshmi Balakrishna
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:2811-2819
Lipopolysaccharide (LPS), or endotoxin, a structural component of gram-negative bacterial outer membranes, plays a key role in the pathogenesis of septic shock, a syndrome of severe systemic inflammation which leads to multiple-system organ failure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65aeee5d3070b439764e6f63eff6ba0
https://doi.org/10.1128/aac.00200-07
https://doi.org/10.1128/aac.00200-07
Publikováno v:
Molecular pharmacology. 82(4)
α7 nicotinic acetylcholine receptors (nAChRs) have been a puzzle since their discovery in brain and non-neuronal tissues. Maximal transient probability of an α7 nAChR being open with rapid agonist applications is only 0.002. The concentration depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd454df08d03459d8c88d41f07dcc85
https://pubmed.ncbi.nlm.nih.gov/22828799
https://pubmed.ncbi.nlm.nih.gov/22828799
Autor:
Subbalakshmi S. Malladi, Apurba Datta, Wenyan Wu, Matthew R. Kimbrell, Rehman Ukani, Sunil A. David, Hemamali J. Warshakoon, Michael W. Amolins, Rongti Li
The N-termini of bacterial lipoproteins are acylated with a (S)-(2,3-bisacyloxypropyl)cysteinyl residue. Lipopeptides derived from lipoproteins activate innate immune responses by engaging Toll-like receptor 2 (TLR2) and are highly immunostimulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9564299d62546a9905398a35a9b4bd11
https://europepmc.org/articles/PMC2859677/
https://europepmc.org/articles/PMC2859677/
Publikováno v:
ChemInform. 40
Chronic immune activation is a hallmark of progressive HIV infection. Recent reports point to the engagement of toll-like receptor 7 (TLR7) and -9 by viral RNA as contributing to the activation of innate immune responses, which drive viral replicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9487e7b1fc9a24baf36337e7b3d74005
https://doi.org/10.1002/chin.200936153
https://doi.org/10.1002/chin.200936153
Autor:
Hemamali J. Warshakoon, Matthew R. Kimbrell, Diptesh Sil, Timothy P. Day, Sunil A. David, Subbalakshmi S. Malladi, Samusi A. Adediran
Publikováno v:
Molecular pharmaceutics. 6(5)
Amphotericin B (AmB), a well-known polyene antifungal agent, displays a marked tendency to self-associate and, as a consequence, exhibits very poor solubility in water. The therapeutic index of AmB is low and is associated with significant dose-relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7cac166fd2d89965f6c441debc33980
https://pubmed.ncbi.nlm.nih.gov/19663403
https://pubmed.ncbi.nlm.nih.gov/19663403
Autor:
Nikunj M. Shukla, Hemamali J. Warshakoon, Diptesh Sil, Jennifer D. Hood, Sunil A. David, Subbalakshmi S. Malladi, Geetanjali Agnihotri, Wenyan Wu, Matthew R. Kimbrell
Publikováno v:
Human vaccines. 5(6)
Toll-like receptors (TLRs) are a family of conserved pattern recognition receptors (PRRs) that recognize pathogen associated molecular patterns and serve as primary sensors of the innate immune system. Ten members of the TLR family have so far been i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0428d4a6800f542548615625b85e10b
https://pubmed.ncbi.nlm.nih.gov/19270494
https://pubmed.ncbi.nlm.nih.gov/19270494
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(8)
Chronic immune activation is a hallmark of progressive HIV infection. Recent reports point to the engagement of toll-like receptor 7 (TLR7) and -9 by viral RNA as contributing to the activation of innate immune responses, which drive viral replicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7408562c58afd5d719065744d4b38b
https://pubmed.ncbi.nlm.nih.gov/19285861
https://pubmed.ncbi.nlm.nih.gov/19285861