Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Matthew R. Hynd"'
Autor:
Matthew R. Hynd, Karen L. Smith, William Shain, Natalie Dowell-Mesfin, Hong Wu, Bruce J. Herron, Sung June Kim
Publikováno v:
Journal of Neuroscience Methods. 203:398-406
Neural prosthetic devices are showing increasing clinical use for the treatment of a variety of neurological disorders. However the functions on these devices are often limited due to an inability to effectively and chronically interface with neural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadffccde2691b011b264fd273aa4654
https://doi.org/10.1016/j.jneumeth.2011.09.023
https://doi.org/10.1016/j.jneumeth.2011.09.023
Autor:
Natalie Dowell-Mesfin, William Shain, Matthew R. Hynd, James N. Turner, Shalin J. Jhaveri, Christopher K. Ober
Publikováno v:
Biomacromolecules. 10:174-183
Local pharmacological intervention may be needed to ensure the long-term performance of neural prosthetic devices because of insertion-related neuron loss and reactive cell responses that form compact sheaths, leading to decreased device performance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e83ae1d809c2239981f83fe6137309
https://doi.org/10.1021/bm801101e
https://doi.org/10.1021/bm801101e
Publikováno v:
Journal of Neuroscience Methods. 173:67-73
Primary dorsal root ganglia (DRG) neurons are often used to investigate the relative strength of various guidance cues to promote re-growth in vitro. Current methods of neuron isolation are laborious and disposal of excess dissected cells is ineffici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f74fbee87ee988b70666c4b5b4fd116
https://doi.org/10.1016/j.jneumeth.2008.05.017
https://doi.org/10.1016/j.jneumeth.2008.05.017
Autor:
William Shain, Matthew R. Hynd, Sang Beom Jun, Badrinath Roysam, Sung June Kim, Yousef Al-Kofahi, Natalie Dowell-Mesfin
Publikováno v:
Journal of Neural Engineering. 5:203-213
Polyacrylamide and poly(ethylene glycol) diacrylate hydrogels were synthesized and characterized for use as drug release and substrates for neuron cell culture. Protein release kinetics was determined by incorporating bovine serum albumin (BSA) into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4b61d1917d3d4647866fb8ccdf2f2e
https://doi.org/10.1088/1741-2560/5/2/011
https://doi.org/10.1088/1741-2560/5/2/011
Publikováno v:
Journal of Neural Engineering. 4:399-409
One limitation to the use of neuroprosthestic devices for chronic application, in the treatment of disease, is the reactive cell responses that occur surrounding the device after insertion. These cell and tissue responses result in increases in devic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a8224e5515fde85789c3981cdc6eb1
https://doi.org/10.1088/1741-2560/4/4/006
https://doi.org/10.1088/1741-2560/4/4/006
Autor:
David L. Martin, William Shain, Matthew R. Hynd, John P. Frampton, Natalie Dowell-Mesfin, Mary-Rose Burnham, James N. Turner
Publikováno v:
Journal of Biomedical Materials Research Part A. :347-354
Patterning of multiple proteins and enzymes onto biocompatible surfaces can provide multiple signals to control cell attachment and growth. Acrylamide-based hydrogels were photo-polymerized in the presence of streptavidin-acrylamide, resulting in pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c22942928517abe70c5dec03386c137
https://doi.org/10.1002/jbm.a.31002
https://doi.org/10.1002/jbm.a.31002
Autor:
Wageesha Senaratne, James N. Turner, Christopher K. Ober, Matthew R. Hynd, Shalin J. Jhaveri, Prabuddha Sengupta, Shain Willia
Publikováno v:
Journal of Photopolymer Science and Technology. 19:435-440
Two- and three-dimensional lithographic strategies were used to fabricate materials which enable control and study of biological processes with high efficiency. Electron-beam lithography was used to produce 2D patterns of micrometer-sized features of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ac4c49957ad98b90d8a2f60e06cc5dc
https://doi.org/10.2494/photopolymer.19.435
https://doi.org/10.2494/photopolymer.19.435
Publikováno v:
Journal of Neurochemistry. 89:240-247
Previous work had shown that the ratio of NMDA receptor NR1 subunit mRNA transcripts containing an N-terminal splice cassette to those that do not is markedly lower in regions of the Alzheimer's disease (AD) brain that are susceptible to pathological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744c8759f17ba78222cb75737fa27162
https://doi.org/10.1111/j.1471-4159.2003.02330.x
https://doi.org/10.1111/j.1471-4159.2003.02330.x
Publikováno v:
Journal of Neurochemistry. 85:543-562
The use of human brain tissue obtained at autopsy for neurochemical, pharmacological and physiological analyses is reviewed. RNA and protein samples have been found suitable for expression profiling by techniques that include RT-PCR, cDNA microarrays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c3bd421f80a2fad564ff0ce800cbedd
https://doi.org/10.1046/j.1471-4159.2003.01747.x
https://doi.org/10.1046/j.1471-4159.2003.01747.x
Publikováno v:
Brain Research Protocols. 11:67-79
The NMDA-selective ionotropic receptor constitutes one of the three principal classes of L-glutamate receptors within the mammalian brain. It plays key roles in neuronal differentiation and synapse consolidation, activity-dependent forms of synaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8537b5b928e1a14d4e6e0901e3145a
https://doi.org/10.1016/s1385-299x(03)00017-5
https://doi.org/10.1016/s1385-299x(03)00017-5