Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Matthew R. Hildebrandt"'
Autor:
Rebecca S. F. Mok, Wenbo Zhang, Taimoor I. Sheikh, Kartik Pradeepan, Isabella R. Fernandes, Leah C. DeJong, Gabriel Benigno, Matthew R. Hildebrandt, Marat Mufteev, Deivid C. Rodrigues, Wei Wei, Alina Piekna, Jiajie Liu, Alysson R. Muotri, John B. Vincent, Lyle Muller, Julio Martinez-Trujillo, Michael W. Salter, James Ellis
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by heterozygous loss-of-function mutations in the X-linked gene MECP2 that is a global transcriptional regulator. Mutations in the methyl-CpG binding domain (MBD) o
Externí odkaz:
https://doaj.org/article/d539f76d9ee84f05a36dd38c22599078
Autor:
Matthew R. Hildebrandt, Miriam S. Reuter, Wei Wei, Naeimeh Tayebi, Jiajie Liu, Sazia Sharmin, Jaap Mulder, L. Stephen Lesperance, Patrick M. Brauer, Rebecca S.F. Mok, Caroline Kinnear, Alina Piekna, Asli Romm, Jennifer Howe, Peter Pasceri, Guoliang Meng, Matthew Rozycki, Deivid C. Rodrigues, Elisa C. Martinez, Michael J. Szego, Juan C. Zúñiga-Pflücker, Michele K. Anderson, Steven A. Prescott, Norman D. Rosenblum, Binita M. Kamath, Seema Mital, Stephen W. Scherer, James Ellis
Publikováno v:
Stem Cell Reports, Vol 13, Iss 6, Pp 1126-1141 (2019)
Summary: Induced pluripotent stem cells (iPSC) derived from healthy individuals are important controls for disease-modeling studies. Here we apply precision health to create a high-quality resource of control iPSCs. Footprint-free lines were reprogra
Externí odkaz:
https://doaj.org/article/7ac621f9b435435cbc07d7300e6d6051
Autor:
Jaap Mulder, Stephen W. Scherer, Rebecca S.F. Mok, Naeimeh Tayebi, Deivid C. Rodrigues, Sazia Sharmin, Guoliang Meng, Michele K. Anderson, James Ellis, Seema Mital, Peter Pasceri, Juan Carlos Zúñiga-Pflücker, Jennifer L. Howe, Wei Wei, Norman D. Rosenblum, Caroline Kinnear, Jiajie Liu, Binita M. Kamath, Asli Romm, Matthew Rozycki, Michael J. Szego, Lee Stephen Lesperance, Miriam S. Reuter, Patrick M. Brauer, Matthew R. Hildebrandt, Alina Piekna, Elisa C. Martinez, Steven A. Prescott
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 13, Iss 6, Pp 1126-1141 (2019)
Stem Cell Reports, Vol 13, Iss 6, Pp 1126-1141 (2019)
Summary Induced pluripotent stem cells (iPSC) derived from healthy individuals are important controls for disease-modeling studies. Here we apply precision health to create a high-quality resource of control iPSCs. Footprint-free lines were reprogram
Autor:
Lubna Yasmin, Matthew R. Hildebrandt, Lei Li, Yixiong Wang, Roseline Godbout, Darryl D. Glubrecht
Publikováno v:
Developmental Biology. 455:420-433
Temporally-regulated maternal RNA translation is essential for embryonic development, with defective degradation resulting in stalled 2-cell embryos. We show that DDX1, a DEAD box protein implicated in RNA transport, may be a key regulator of materna
Autor:
Wilson W L Sung, S. Mohsen Hosseini, Brett Trost, Stephen W. Scherer, John Wei, James Ellis, Jeffrey R. MacDonald, Sarah Bowdin, Janet A. Buchanan, M. Stephen Meyn, Miriam S. Reuter, Rohan V. Patel, Giovanna Pellecchia, Allison Hazell, Ryan A. Cook, Sergio L. Pereira, Bhooma Thiruvahindrapuram, Jennifer L. Howe, Iris Cohn, Lisa J. Strug, Ryan K. C. Yuen, Peter Pasceri, Yvonne Bombard, Joe Whitney, Hin C. Lee, Tara Paton, Anne S. Bassett, Rosanna Weksberg, Jill Davies, Barbara Kellam, Dimitri J. Stavropoulos, Wei Wei, Christian R. Marshall, Cheryl Shuman, Marc Fiume, Fred W. Keeley, Richard F. Wintle, Matthew R. Hildebrandt, Jo Anne Herbrick, Zhuozhi Wang, Peter N. Ray, Thomas Nalpathamkalam, Ronald D. Cohn, Sherilyn L. Bell, Neal Sondheimer, Daniele Merico, Susan Walker, Ann M. Joseph-George, Melanie M. Mahtani, Asli Romm, Chao Lu, Michael J. Szego, Nasim Monfared
Publikováno v:
Canadian Medical Association Journal. 190:E126-E136
BACKGROUND: The Personal Genome Project Canada is a comprehensive public data resource that integrates whole genome sequencing data and health information. We describe genomic variation identified in the initial recruitment cohort of 56 volunteers. M
Autor:
Lei Li, Roseline Godbout, Richard P. Fahlman, Devon R. Germain, Elizabeth A. Monckton, Ho-Yin Poon, Matthew R. Hildebrandt
Publikováno v:
DNA Repair. 55:47-63
Human Rap1-interacting factor 1 (RIF1) is an important player in the repair of DNA double strand breaks (DSBs). RIF1 acts downstream of 53BP1, with well-documented roles in class switch recombination in B-cells and inhibition of end resection initiat
Autor:
Lei Li, Roseline Godbout, Michael J. Hendzel, Elizabeth A. Monckton, Ho-Yin Poon, Darin McDonald, Matthew R. Hildebrandt, Devon R. Germain
Publikováno v:
Molecular and Cellular Biology. 36:2794-2810
Although RNA and RNA-binding proteins have been linked to double-strand breaks (DSBs), little is known regarding their roles in the cellular response to DSBs and, if any, in the repair process. Here, we provide direct evidence for the presence of RNA
Autor:
Jaap, Mulder, Sazia, Sharmin, Theresa, Chow, Deivid Carvalho, Rodrigues, Matthew R, Hildebrandt, Robert, D'Cruz, Ian, Rogers, James, Ellis, Norman D, Rosenblum
Publikováno v:
Pediatric research. 87(4)
Human induced pluripotent stem cells (iPSCs) are a promising tool to investigate pathogenic mechanisms underlying human genetic conditions, such as congenital anomalies of the kidney and urinary tract (CAKUT). Currently, iPSC-based research in pediat
Autor:
Patrick M. Brauer, Jaap Mulder, Juan Carlos Zúñiga-Pflücker, Jennifer L. Howe, Rebecca S.F. Mok, Peter Pasceri, Matthew R. Hildebrandt, Caroline Kinnear, Naeimeh Tayebi, Stephen W. Scherer, Matthew Rozycki, Michael J. Szego, Deivid C. Rodrigues, Asli Romm, Michele K. Anderson, Lee Stephen Lesperance, Guoliang Meng, Alina Piekna, James Ellis, Steven A. Prescott, Jiajie Liu, Elisa C. Martinez, Binita M. Kamath, Seema Mital, Sazia Sharmin, Wei Wei, Miriam S. Reuter, Norman D. Rosenblum
SummaryInduced Pluripotent Stem Cells (iPSC) derived from healthy individuals are important controls for disease modeling studies. To create a resource of genetically annotated iPSCs, we reprogrammed footprint-free lines from four volunteers in the P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b0cbef22ce3495a2def013199daf7f
Autor:
Miranda Brun, Devon R. Germain, Roseline Godbout, Matthew R. Hildebrandt, Elizabeth A. Monckton
Publikováno v:
Scientific Reports
DEAD box 1 (DDX1) is a member of the DEAD box family of RNA helicases which are involved in all aspects of RNA metabolism. DDX1 has been implicated in a variety of biological processes, including 3’-end processing of mRNA, DNA repair, microRNA proc