Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Matthew R. Hight"'
Autor:
Qin Zhang, Dennis K. Jeppesen, James N. Higginbotham, Michelle Demory Beckler, Emily J. Poulin, Alex J. Walsh, Melissa C. Skala, Eliot T. McKinley, H. Charles Manning, Matthew R. Hight, Michael L. Schulte, Kimberly R. Watt, G. Daniel Ayers, Melissa M. Wolf, Gabriela Andrejeva, Jeffrey C. Rathmell, Jeffrey L. Franklin, Robert J. Coffey
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 627-629.e6 (2018)
Externí odkaz:
https://doaj.org/article/2f29401d5351432ba699592b4cc25b76
Autor:
H. Charles Manning, Nipun Merchant, Chanjuan Shi, M. Kay Washington, Frank Revetta, Jarrod A. Smith, Mohammed Noor Tantawy, Gregory D. Ayers, Mingfeng Bai, Qing Xie, Dawei Zhang, Yang Liu, Adria Payne, Allie Fu, Eliot McKinley, Matthew R. Hight, Jun Li, Allison S. Cohen
[18F]V-1008 localization observed in Ptf1a-Cre;LSL-KrasG12D/+;Tgfbr2+/- (KTC) pancreatic lesions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc70c25a478fe0e210512b65bf4ae4c
https://doi.org/10.1158/1078-0432.22476518.v1
https://doi.org/10.1158/1078-0432.22476518.v1
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 90KB, Scheme 1. 19FFB-VAD-FMK (3) (A) and 127IIZ-VAD-FMK (5) (B) synthetic schemes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888ba9dc16f20baa6ca82445a33c310a
https://doi.org/10.1158/1078-0432.22447991
https://doi.org/10.1158/1078-0432.22447991
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
Purpose: Apoptosis, or programmed cell death, can be leveraged as a surrogate measure of response to therapeutic interventions in medicine. Cysteine aspartic acid–specific proteases, or caspases, are essential determinants of apoptosis signaling ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0fbe78ef763d965cf39ffd36bb1228
https://doi.org/10.1158/1078-0432.c.6521267.v1
https://doi.org/10.1158/1078-0432.c.6521267.v1
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 79KB, 19FFB-VAD-FMK and parent peptide enzyme selectivity. Biochemistry, fluorescence measured IC50 values, collected as duplicates, of the parent peptide, VAD-FMK, and 19FFB-VAD-FMK against caspases-3/6/7/8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0557abef2d4bdfa3dcf3d12cadc7b43a
https://doi.org/10.1158/1078-0432.22447994
https://doi.org/10.1158/1078-0432.22447994
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 165KB, Supplemental Materials and Methods, Figure Legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b3efe4bbbe341fd729ace9ce340ff2
https://doi.org/10.1158/1078-0432.22447982.v1
https://doi.org/10.1158/1078-0432.22447982.v1
Autor:
H. Charles Manning, Nipun Merchant, Chanjuan Shi, M. Kay Washington, Frank Revetta, Jarrod A. Smith, Mohammed Noor Tantawy, Gregory D. Ayers, Mingfeng Bai, Qing Xie, Dawei Zhang, Yang Liu, Adria Payne, Allie Fu, Eliot McKinley, Matthew R. Hight, Jun Li, Allison S. Cohen
Purpose:Pancreatic cancer is among the most aggressive malignancies and is rarely discovered early. However, pancreatic “incidentalomas,” particularly cysts, are frequently identified in asymptomatic patients through anatomic imaging for unrelate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78be6d9da0df56b95e889dbd8d7407b5
https://doi.org/10.1158/1078-0432.c.6529412
https://doi.org/10.1158/1078-0432.c.6529412
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 137KB, IHC semi-quantification. Semi-quantitative analysis of cleaved caspase-3 histological samples of DLD-1 and SW620 xenograft tumors treated with vehicle or AZD-1152 (A). Evaluation of multiple low field (2.5x) micrographs revealed a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ea45e9e55938c4ee72be9a67033bec
https://doi.org/10.1158/1078-0432.22447985
https://doi.org/10.1158/1078-0432.22447985
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 93KB, Scheme 2. 18FSFB (9) (A) and 18FFB-VAD-FMK (11) (B) synthetic schemes. Compound (9) radiosynthesis was performed systematically using an automated radiochemistry module.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239836094c3fb17d7e7b7d00c483b3be
https://doi.org/10.1158/1078-0432.22447988.v1
https://doi.org/10.1158/1078-0432.22447988.v1
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 43KB, Docking scores are reported as ranked by the Crash (steric repulsion) score from the protein flexibility (PF-score) scoring function of the Tripos SYBYL-X v2.0 software suite that also features (among other scoring parameters) compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d1703fb7d31ab46f15c792fb611703
https://doi.org/10.1158/1078-0432.22447979
https://doi.org/10.1158/1078-0432.22447979