Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Matthew R. Hester"'
Autor:
Daniel P. Walker, Barbara A. Olson, Fusen Han, E. Jon Jacobsen, Raymond S. Hurst, Shaojuan Jia, Lester A. Dolak, Brandon J. Margolis, Nicole R. Higdon, Tatiana N. Vetman, David W. Piotrowski, Brian A. Staton, Matthew R. Hester, Luz A. Cortes-Burgos, Erik H. F. Wong, Theron M. Wall, Steven Charles Reitz, Vincent E. Groppi, Bruce N. Rogers, Kai S. Li, Brad A. Acker, Bruce A. Thornburgh, Paula M. Tinholt, Jason K. Myers, Mihály Hajós, Thomas J. Raub, Mark L. Wolfe, Karen M. Yates, William E. Hoffmann, Laura Fitzgerald, Donn G. Wishka, Eric P. Seest, Rodney R. Walters
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8219-8248
A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the alpha7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed alpha7 nAChR agonist, PNU-282,987, whil
Autor:
Richard A. Hohler, Taylor Wendy Dianne, Paul M. Herrinton, Eric P. Seest, Steven P. Tanis, Bruce Roy Evans, Matthew R. Hester, Timothy Parker, James A. Nieman, Steven E. Heasley, Perrault William R, Lester A. Dolak
Publikováno v:
Tetrahedron: Asymmetry. 17:2154-2182
As part of medicinal chemistry efforts we found it necessary to develop general syntheses of highly enantiomerically enriched 1-aryl-2-chloroethanols and 1-aryl-2-methylaminoethanols. A survey of literature methods suggested that a truly general appr
Autor:
Brian D. Wakefield, Gregg M. Kamilar, Michael T. Sweeney, Earline P. Melchior, Donna L. Romero, Scott D. Larsen, J. Craig Ruble, Keith R. Marotti, Matthew R. Hester
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(24)
The novel bacterial transcription/translation (TT) inhibitor 1 was identified through a combination of high throughput screening and exploratory medicinal chemistry. Initial optimization of the anthranilic acid moiety and sulfonamide amine diversity
Publikováno v:
ChemInform. 21
Derivatives of 2,2′,7,7′-tetrahydroxy-1,1′-binaphthyl (5) are synthetically readily available chiral shapes with a major and a minor groove. Previous work by Cram et al. has shown that efficient chiral crown ether binding sites can be construct
Autor:
Kyria L. Boundy, Judith K. Guy, Craig M. Van Zyl, Michael P. Doyle, Surendra N. Mahapatro, Matthew R. Hester
Publikováno v:
Inorganic Chemistry. 26:3387-3392
Publikováno v:
Israel Journal of Chemistry. 29:201-212
Derivatives of 2,2′,7,7′-tetrahydroxy-1,1′-binaphthyl (5) are synthetically readily available chiral shapes with a major and a minor groove. Previous work by Cram et al. has shown that efficient chiral crown ether binding sites can be construct
Publikováno v:
Angewandte Chemie International Edition in English. 27:1705-1711
Publikováno v:
Angewandte Chemie. 100:1775-1777
Autor:
Matthew R. Hester, Surendra N. Mahapatro, K. L. Boundy, Michael P. Doyle, Judith K. Guy, C. M. Van Zyl
Publikováno v:
ChemInform. 19
Publikováno v:
Journal of the American Chemical Society. 107:6136-6137