Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthew R. Hart"'
Autor:
Avradip Chatterjee, Brad Gallent, Madhusudhanarao Katiki, Chen Qian, Matthew R. Harter, Steve Silletti, Elizabeth A. Komives, Michael R. Freeman, Ramachandran Murali
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The CUT and homeodomain are ubiquitous DNA binding elements often tandemly arranged in multiple transcription factor families. However, how the CUT and homeodomain work concertedly to bind DNA remains unknown. Using ONECUT2, a driver and the
Externí odkaz:
https://doaj.org/article/9fba830ea6bc42999be2459ed6b468de
Autor:
Jin Dai, Sara Borst, Jean Ann Maguire, Pamela S. Becker, Sylvia Chien, Sioban Keel, Deborah L. French, Michelle C Krutein, Michaela R. DelPriore, Marshall S. Horwitz, Donovan J. Anderson, Matthew R. Hart, Jasmin Jeffery, Paul Gadue, Eirini P. Papapetrou, Andriana G. Kotini
Publikováno v:
Blood Adv
RUNX1 familial platelet disorder (RUNX1-FPD) is an autosomal dominant disorder caused by a monoallelic mutation of RUNX1, initially resulting in approximately half-normal RUNX1 activity. Clinical features include thrombocytopenia, platelet functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77576fa734bd4297ba790c76a89d083
https://doi.org/10.1182/bloodadvances.2020002709
https://doi.org/10.1182/bloodadvances.2020002709
Autor:
Alec B. Wilkens, Elena C. Fulton, Margot J. Pont, Gabriel O. Cole, Isabel Leung, Sylvia M. Stull, Matthew R. Hart, Irwin D. Bernstein, Scott N. Furlan, Stanley R. Riddell
Publikováno v:
Blood. 140(21)
Adoptive transfer of T cells expressing chimeric antigen receptors (CAR-T) effectively treats refractory hematologic malignancies in a subset of patients but can be limited by poor T-cell expansion and persistence in vivo. Less differentiated T-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cd4cb1d68215b933a4794bce5f0902
https://pubmed.ncbi.nlm.nih.gov/36422861
https://pubmed.ncbi.nlm.nih.gov/36422861
Autor:
Marshall S. Horwitz, Tobias Neff, Matthew R. Hart, Christopher C. Porter, Donovan J. Anderson, Michael Levin
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 9, p e1007642 (2018)
PLoS Genetics, Vol 14, Iss 9, p e1007642 (2018)
PAX5, one of nine members of the mammalian paired box (PAX) family of transcription factors, plays an important role in B cell development. Approximately one-third of individuals with pre-B acute lymphoblastic leukemia (ALL) acquire heterozygous inac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f835a0d77617f1f0b23f86f09ed4462a
http://europepmc.org/articles/PMC6157899
http://europepmc.org/articles/PMC6157899
Publikováno v:
Molecular Therapy. 21:1996-2007
The ERBB receptors are a family of heterodimerization partners capable of driving transformation and metastasis. While the therapeutic targeting of single receptors has proven efficacious, optimal targeting of this receptor family should target all o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af35a380836a5a21d70501d3d815fa4
https://doi.org/10.1038/mt.2013.196
https://doi.org/10.1038/mt.2013.196
Autor:
Aneta Czaplinska, Aimee L. Desaki, Maureen P. Howell, Bryan I. Smith, Kevin S. Brockway, Ben J. Duncan, Annabel R. Laramee, Shanna R. Fischer, Tsuey-Ming Chen, Reena Kawal, Nancy Ao, Agnes J. Liang, Amy Bernard, Casey Faber, Ed S. Lein, Geralyn J. Orta, Kevin R. Halverson, Jennifer G. Dougherty, Chinh Dang, Cliff Frensley, Caroline C. Overly, Judith J. Morgan, Murat B. Yaylaoglu, Mark S. Boguski, Lee R. Varnam, Susan M. Sunkin, Crissa K. Wolkey, Amanda Ebbert, Matthew J.A. Wood, Paul Wohnoutka, Benjamin A.C. Facer, Li Chen, Jesse Michaels, James H. Lake, Carey D. Teemer, Rebecca A. Johnson, Axel Visel, Marty Mortrud, Michael Hawrylycz, Christina Thaller, Nerick Mosqueda, Victoria Y. Wong, Tim A. Dolbeare, Xu Feng Yuan, Mei Chi Chin, Marcos J. Ruiz, Carol L. Thompson, Katherine Schaffnit, Theresa A. Zwingman, Sayan Dev Pathak, Tracy Lemon, Lydia Ng, Jimmy Chong, Lili K. Estin, Simon Smith, Rob Young, Kirk D. Larsen, Joshua J. Royall, Randy Ng, Rachel H. Knapik, Mikael Ayres, Nick Dee, Sheana Parry, Ray M. Whitlock, Kenda-Ruth Stumpf, Nadiya V. Shapovalova, Emi J. Byrnes, Taz Sivisay, Matthew R. Hart, Chihchau L. Kuan, Owen C. Pearson, Ellen Diep, Nadia R. Sarno, Madhavi Sutram, Andrew F. Boe, Clifford R. Slaughterbeck, Zackery L. Riley, Rebecca J. Morgan, Hong-Wei Dong, Tsega Desta, Patrick T. Karr, Andy J. Sodt, John G. Hohmann, Suvro Datta, Stephen A. Rowland, Tu H. Pak, Ralph B. Puchalski, Lin Chen, Nick N. Stewart, Ying Liu, Hannah R. Rockett, Brian L. Youngstrom, Darren P. Jeung, Lon T. Luong, Matthew J. Donelan, Amy Bensinger, Katie J. Glattfelder, Bin Zhang, Allan R. Jones, Gregor Eichele, Rick Fields, Sabrina N. Gates, Kimberly A. Smith, Angelene Tam, Brian E. Crook, Tim P. Fliss, Jolene Kidney, Christopher Lau
Publikováno v:
Nature. 445:168-176
Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f1bcef3c42664230a6393b0bffc31d
https://doi.org/10.1038/nature05453
https://doi.org/10.1038/nature05453
Publikováno v:
International Journal of Oncology
Bcl-2 and other anti-apoptotic proteins are associated with defective caspase-dependent apoptotic pathways, resulting in chemoresistance. We have previously shown that ATN-224, a copper chelator drug, induces cell death in murine thymic lymphoma cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dde08a99fb948b952f35c94674973fd
https://pubmed.ncbi.nlm.nih.gov/24788952
https://pubmed.ncbi.nlm.nih.gov/24788952
Autor:
Marshall S. Horwitz, Matthew R. Hart
Publikováno v:
Blood. 126:2445-2445
Pre-B cell ALL is the most common pediatric malignancy. More than a third of cases acquire loss-of-function mutations of PAX5, a regulatory transcription factor which is required for the differentiation of B lymphocytes. Additionally, germline loss o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f32d969564621f45af680410a7020b32
https://doi.org/10.1182/blood.v126.23.2445.2445
https://doi.org/10.1182/blood.v126.23.2445.2445
Publikováno v:
Science and Technology of Advanced Materials, Vol 17, Iss 1, Pp 89-97 (2016)
To expand the chemical capabilities of 3D printed structures generated from commercial thermoplastic printers, we have produced and printed polymer filaments that contain inorganic nanoparticles. TiO2 was dispersed into acrylonitrile butadiene styren
Externí odkaz:
https://doaj.org/article/3ae5532807ba4438b6ea3b81dfde4737
Autor:
Seung-Gi Jin, Zhi-Min Zhang, Thomas L. Dunwell, Matthew R. Harter, Xiwei Wu, Jennifer Johnson, Zheng Li, Jiancheng Liu, Piroska E. Szabó, Qiang Lu, Guo-liang Xu, Jikui Song, Gerd P. Pfeifer
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 493-505 (2016)
We report that the mammalian 5-methylcytosine (5mC) oxidase Tet3 exists as three major isoforms and characterized the full-length isoform containing an N-terminal CXXC domain (Tet3FL). This CXXC domain binds to unmethylated CpGs, but, unexpectedly, i
Externí odkaz:
https://doaj.org/article/47abb58ffc4b449a8f329dae7b4c6882