Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Matthew R. Griffiths"'
Autor:
Somhairle Maccormick, Steven Durrant, Anisa Nizarali Virani, Christopher John Davis, Steve Young, Golec Julian M C, Storck Pierre Henri, Philip Michael Reaper, David Kay, John Pollard, Michael O'donnell, Heather Twin, Jean-Damien Charrier, Peter Littlewood, Matthew R. Griffiths, Joanne Pinder, Ronald Knegtel
Publikováno v:
Journal of medicinal chemistry. 62(11)
The DNA damage response (DDR) is a DNA damage surveillance and repair mechanism that can limit the effectiveness of radiotherapy and DNA-damaging chemotherapy, commonly used treatment modalities in cancer. Two related kinases, ataxia telangiectasia m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236bb1d7274297437c1461393876f89b
https://pubmed.ncbi.nlm.nih.gov/31074988
https://pubmed.ncbi.nlm.nih.gov/31074988
Autor:
Matthew R. Griffiths, Judith Freund, Don Smith, Matthew Law, Jeff Hudson, Allison Martin, Investigators, David A. Cooper, Andrew Carr, Sue Kalnins
Publikováno v:
HIV Clinical Trials. 4:45-49
The accurate measurement of total body and subcutaneous fat is essential if therapeutic interventions, aimed at preventing or reversing lipodystrophy syndrome, are to be adequately assessed. The aim of this study was to investigate the variability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2857ff8f210ba5f1945a8f4dcebf53
https://doi.org/10.1310/wrl8-dwh1-7vql-ak81
https://doi.org/10.1310/wrl8-dwh1-7vql-ak81
Autor:
David A. F. Gillespie, Jeremy M. Tavaré, Matthew R. Griffiths, Ainsley A. Culbert, Peter E. Shaw, Elizabeth J. Black, Martin Dickens
Publikováno v:
Biochemical Journal. 335:19-26
The activator protein-1 (AP-1) transcriptional complex is made up of members of the Fos (c-Fos, FosB, Fra1, Fra2) and Jun (c-Jun, JunB, JunD) families and is stimulated by insulin in several cell types. The mechanism by which insulin activates this c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22dcc2b31613341865aaa26a9bbc7a96
https://doi.org/10.1042/bj3350019
https://doi.org/10.1042/bj3350019
Autor:
Matthew R. Griffiths, Hardy Sundaram
Publikováno v:
Methods in Molecular Biology ISBN: 9781617790799
Drug design is an iterative process requiring cycles of compound synthesis and testing, with each successive synthesis phase yielding molecules predicted to have improved characteristics over the previous set of compounds. In the field of cancer drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75d831f733083130840271fb1f6640a1
https://doi.org/10.1007/978-1-61779-080-5_36
https://doi.org/10.1007/978-1-61779-080-5_36
Autor:
Golec Julian M C, Peter A. Charlton, Jean-Damien Charrier, Joanna M Long, Matthew R. Griffiths, Somhairle Maccormick, Philip Michael Reaper, John Pollard
Publikováno v:
Nature chemical biology. 7(7)
Here we report a comprehensive biological characterization of a potent and selective small-molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound synthetic lethal interaction between ATR and the ATM-p53 tumor suppressor pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd45edc683c9cc9064334f3aae74b6c
https://pubmed.ncbi.nlm.nih.gov/21490603
https://pubmed.ncbi.nlm.nih.gov/21490603
Autor:
Torsten Stein, Matthew R. Griffiths, Barry A. Gusterson, Martin John Page, Joanna S. Morris, Andrew R. Pitt, Claire R. Davies
Publikováno v:
Proteomics. 6(21)
After lactation, the mouse mammary gland undergoes apoptosis and tissue remodelling as the gland reverts to its prepregnant state. This complex change was investigated using 2-DE. An integrated database was produced from lactation and involution prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e524e0a9b3029889c392964469d78408
https://pubmed.ncbi.nlm.nih.gov/17022101
https://pubmed.ncbi.nlm.nih.gov/17022101
Autor:
Barry A. Gusterson, Thakor Patel, James A. Bruce, Athula Herath, Matthew R. Griffiths, Martin John Page, Joanna S. Morris, Claire R. Davies
Publikováno v:
Proteomics. 4(6)
Ductal morphogenesis in the mouse mammary gland occurs mainly postnatally and is driven by specialized structures at the ends of the developing ducts, the terminal end buds (TEBs), which later regress once ductal growth is complete. To identify prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3885cf52bcadd386c7a7d96989ae674a
https://pubmed.ncbi.nlm.nih.gov/15174146
https://pubmed.ncbi.nlm.nih.gov/15174146
Publikováno v:
Proteomics. 4(4)
Adipose tissue plays a crucial endocrine role in controlling whole body glucose homeostasis and insulin sensitivity. Given the substantial rise in obesity and obesity-related diseases such as diabetes, it is important to understand the molecular basi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7a98875dd9b13a8d598d5372146c8d
https://pubmed.ncbi.nlm.nih.gov/15048985
https://pubmed.ncbi.nlm.nih.gov/15048985
Autor:
Joseph C H, Wong, Matthew R, Griffiths
Publikováno v:
Australasian radiology. 47(3)
The precision error of the bone densitometer is used to interpret significant change in bone mineral density (BMD) in serial studies. The precision error can be expressed as standard deviation (SD) or coefficient of variation (CV). The aims of this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8c3f35c6eb299106ecbc8399049bdd2
https://pubmed.ncbi.nlm.nih.gov/12890241
https://pubmed.ncbi.nlm.nih.gov/12890241
Autor:
Helen R. Poyser, Laurent Daviet, Raj Parekh, Sonal Patel, Kerry Louise Tyson, Adrian L. Harris, Alasdair Stamps, Julie A. Loader, Lindsey Hudson, Graham Steers, Matthew R. Griffiths, Paul J. Adam, Pierre Legrain, Joanne Berry, Fletcher Graham Charles, Raymond R. Townsend, Jonathan A Terrett, Robert Boyd, Nick Redpath
Publikováno v:
The Journal of biological chemistry. 278(8)
Proteins associated with cancer cell plasma membranes are rich in known drug and antibody targets as well as other proteins known to play key roles in the abnormal signal transduction processes required for carcinogenesis. We describe here a proteomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28dcc11e9d5bd255241ad3d5d5a477eb
https://pubmed.ncbi.nlm.nih.gov/12477722
https://pubmed.ncbi.nlm.nih.gov/12477722