Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Matthew R. Garcia"'
Autor:
Madeline B. Searcy, Randolph K. Larsen, Bradley T. Stevens, Yang Zhang, Hongjian Jin, Catherine J. Drummond, Casey G. Langdon, Katherine E. Gadek, Kyna Vuong, Kristin B. Reed, Matthew R. Garcia, Beisi Xu, Darden W. Kimbrough, Grace E. Adkins, Nadhir Djekidel, Shaina N. Porter, Patrick A. Schreiner, Shondra M. Pruett-Miller, Brian J. Abraham, Jerold E. Rehg, Mark E. Hatley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) driven by the expression of the PAX3-FOXO1 (P3F) fusion oncoprotein is an aggressive subtype of pediatric rhabdomyosarcoma. FP-RMS histologically resembles developing muscle yet occurs throughout the
Externí odkaz:
https://doaj.org/article/af11c11b372b412d83edd57dfaac71cf
Autor:
Casey G. Langdon, Katherine E. Gadek, Matthew R. Garcia, Myron K. Evans, Kristin B. Reed, Madeline Bush, Jason A. Hanna, Catherine J. Drummond, Matthew C. Maguire, Patrick J. Leavey, David Finkelstein, Hongjian Jin, Patrick A. Schreiner, Jerold E. Rehg, Mark E. Hatley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
PTEN copy number loss is found in 25% of fusion-negative rhabdomyosarcomas (FN-RMS). Here, the authors use a Hedgehog-driven FN-RMS mouse model to show that PTEN loss drives the expression of core transcription factor PAX7 and its transcriptional axi
Externí odkaz:
https://doaj.org/article/0413e8410b0248ed86492edc2f4f4634
Autor:
Mark E. Hatley, Jerold E. Rehg, David Finkelstein, Jonathan C. Go, Matthew R. Garcia, Catherine J. Drummond, Jason A. Hanna
Angiosarcoma is an aggressive vascular sarcoma with an extremely poor prognosis. Because of the relative rarity of this disease, its molecular drivers and optimal treatment strategies are obscure. DICER1 is an RNase III endoribonuclease central to mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f726706e802599f3ac8d6c8ea7f10f
https://doi.org/10.1158/0008-5472.c.6509529
https://doi.org/10.1158/0008-5472.c.6509529
Autor:
Mark E. Hatley, Jerold E. Rehg, David Finkelstein, Jonathan C. Go, Matthew R. Garcia, Catherine J. Drummond, Jason A. Hanna
This file contains four supplementary tables and four supplementary figures pertinent to the submitted manuscript as follows: Table S1 lists the Enrichr analysis of miRNA targets in angiosarcoma. Table S2 lists the antibodies used for immunohistochem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3ffa0c6d904f8111713e34b5b71bb2
https://doi.org/10.1158/0008-5472.22416348
https://doi.org/10.1158/0008-5472.22416348
Autor:
Jason A Hanna, Casey G Langdon, Matthew R Garcia, Annaleigh Benton, Nadia A Lanman, David Finkelstein, Jerold E Rehg, Mark E Hatley
Publikováno v:
The Journal of Pathology. 257:109-124
Angiosarcomas are aggressive vascular sarcomas that arise from endothelial cells and have an extremely poor prognosis. Because of the rarity of angiosarcomas, knowledge of molecular drivers and optimized treatment strategies is lacking, highlighting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10600ea8f2be4d3dbe9e013b3f37eae
https://doi.org/10.1002/path.5873
https://doi.org/10.1002/path.5873
Autor:
Mark E. Hatley, Casey G. Langdon, Katherine E. Gadek, Matthew R. Garcia, Catherine J. Drummond, Jason A. Hanna, Hongjian E. Jin, Jerold E. Rehg
Publikováno v:
Clinical Cancer Research. 28:IA013-IA013
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Despite aggressive treatment clinical outcomes for RMS have not improved for three decades, emphasizing the need to uncover the molecular underpinnings of the disease. RMS has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85d98ed72a51eb434dd8cbb8bab57100
https://doi.org/10.1158/1557-3265.sarcomas22-ia013
https://doi.org/10.1158/1557-3265.sarcomas22-ia013
Autor:
Casey G. Langdon, Katherine E. Gadek, Matthew R. Garcia, Myron K. Evans, Kristin B. Reed, Madeline Bush, Jason A. Hanna, Catherine J. Drummond, Matthew C. Maguire, Patrick J. Leavey, David Finkelstein, Hongjian Jin, Patrick A. Schreiner, Jerold E. Rehg, Mark E. Hatley
Publikováno v:
Cancer Research. 82:1667-1667
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children with no improvements in treatment options for RMS patients over the past four decades. Therefore, it is critical to understand the fundamental processes underlying RMS tumorige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c071fdf37d4ca23db824b11c87304aa
https://doi.org/10.1158/1538-7445.am2022-1667
https://doi.org/10.1158/1538-7445.am2022-1667
Autor:
Jordan Roach, Patrick J. Leavey, Jason A. Hanna, Mark E. Hatley, Jonathan C. Go, Dino Maglic, Alexandre Fagnan, Yong Dong Wang, David Finkelstein, Matthew R. Garcia, Alicia Lardennois
Publikováno v:
Oncogene
Rhabdomyosarcoma is the most common soft-tissue sarcoma in childhood and histologically resembles developing skeletal muscle. Alveolar rhabdomyosarcoma (ARMS) is an aggressive subtype with a higher rate of metastasis and poorer prognosis. The majorit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817f2a592a992f6994d609e6706c269e
http://europepmc.org/articles/PMC5895609
http://europepmc.org/articles/PMC5895609
Autor:
David Finkelstein, Jerold E. Rehg, Casey G. Langdon, Madeline Bush, Hongjian Jin, Matthew R. Garcia, Katherine E. Gadek, Catherine J. Drummond, Jason A. Hanna, Patrick J. Leavey, Matthew C. Maguire, Kristin B. Reed, Mark E. Hatley
Publikováno v:
Cancer Research. 81:3022-3022
Rhabdomyosarcoma (RMS) is an embryonal tumor resembling developing skeletal muscle and the most common pediatric soft-tissue sarcoma. RMS is molecularly defined by the presence or absence of a fusion oncoprotein corresponding with the histological su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03372dfe18baa327fe72a828ae9e6abc
https://doi.org/10.1158/1538-7445.am2021-3022
https://doi.org/10.1158/1538-7445.am2021-3022
Publikováno v:
Cancer Research. 80:PR01-PR01
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Despite aggressive chemotherapy, radiotherapy, and surgery, clinical outcomes for RMS have not improved for three decades, emphasizing the need to uncover the molecular underp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff534032cc6f703c342eefbd4d27255
https://doi.org/10.1158/1538-7445.camodels2020-pr01
https://doi.org/10.1158/1538-7445.camodels2020-pr01