Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Matthew R. Gangl"'
Autor:
Lingling Dai, Prerna Bhargava, Kristopher J. Stanya, Ryan K. Alexander, Yae-Huei Liou, David Jacobi, Nelson H. Knudsen, Alexander Hyde, Matthew R. Gangl, Sihao Liu, Chih-Hao Lee
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1186-1197 (2017)
Objective: Alternative activation (M2) of adipose tissue resident macrophage (ATM) inhibits obesity-induced metabolic inflammation. The underlying mechanisms remain unclear. Recent studies have shown that dysregulated lipid homeostasis caused by incr
Externí odkaz:
https://doaj.org/article/591691068e984936bef452226fe6690b
Autor:
Matthew R. Gangl, Ryan K. Alexander, Prerna Bhargava, Yae-Huei Liou, Lingling Dai, Chih-Hao Lee, Sihao Liu, Nelson H. Knudsen, Alexander L. Hyde, Kristopher J. Stanya, David Jacobi
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 10, Pp 1186-1197 (2017)
Molecular Metabolism, Vol 6, Iss 10, Pp 1186-1197 (2017)
Objective Alternative activation (M2) of adipose tissue resident macrophage (ATM) inhibits obesity-induced metabolic inflammation. The underlying mechanisms remain unclear. Recent studies have shown that dysregulated lipid homeostasis caused by incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fddf1fc780ac751c7ee7c1f80647de5
http://europepmc.org/articles/PMC5641682
http://europepmc.org/articles/PMC5641682
Autor:
Jamie A. Cooper, Frank B. Hu, Chad M. Paton, Wendy S. Garrett, Diogo Fonseca-Pereira, Yae-Huei Liou, Eric A. Ortlund, Kyle A Starost, Danesh H. Sopariwala, Ryan K. Alexander, Kristopher J. Stanya, David Jacobi, Vihang A. Narkar, Mayer M. Chalom, Alexander L. Hyde, Jonathan H. Kim, Jun Li, Sihao Liu, Nelson H. Knudsen, Matthew R. Gangl, Chih-Hao Lee
Publikováno v:
Science (New York, N.Y.). 368(6490)
IL-13 hits the gym Interleukin-13 (IL-13) is a cytokine secreted by T cells, innate lymphoid cells (ILC2s), and granulocytes. It acts as a central mediator in allergy and antihelminth defense with various effects. Knudsen et al. report a distinct rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42eae2b120e56189ed96de7ddc7b17d1
https://pubmed.ncbi.nlm.nih.gov/32553179
https://pubmed.ncbi.nlm.nih.gov/32553179
Autor:
Alexander L. Hyde, Ugur Unluturk, David Jacobi, William B. Mair, Xiaohui Kong, Chih-Hao Lee, Nora Kory, Xiaobo Li, Sihao Liu, Nelson H. Knudsen, Kristopher Burkewitz, Matthew R. Gangl, Ryan K. Alexander
Publikováno v:
Cell Metabolism. 22(4):709-720
SummaryMitochondria undergo architectural/functional changes in response to metabolic inputs. How this process is regulated in physiological feeding/fasting states remains unclear. Here we show that mitochondrial dynamics (notably fission and mitopha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe657f1b2a023e4e3f041a0e5a15b8fb
Autor:
Lingling Dai, Alan Saghatelian, Sihao Liu, Gökhan S. Hotamisligil, Matthew R. Gangl, Karen Inouye, Edwin A. Homan, Chih-Hao Lee, Ben Hatano, Mathias Leidl, Kristopher J. Stanya, Jorge Plutzky, Prerna Bhargava, Jonathan D. Brown
Publikováno v:
Nature
Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage or utilization. In mice, this program follows a circadian rhythm that peaks with nocturnal feeding1,2 and is repressed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e822c143cae05cafaf192d2e2336ce31
https://doi.org/10.1038/nature12710
https://doi.org/10.1038/nature12710
Autor:
Chih-Hao Lee, Lingling Dai, David Jacobi, Kristopher J. Stanya, Sihao Liu, Donald A. Harn, Changlin Li, Matthew R. Gangl, Prerna Bhargava
Publikováno v:
Nature medicine
Parasitic worms express host-like glycans to attenuate the immune response of human hosts. The therapeutic potential of this immunomodulatory mechanism in controlling the metabolic dysfunction that is associated with chronic inflammation remains unex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1382834ef65c1fc8aee708af7dc2b4f
http://europepmc.org/articles/PMC3493877
http://europepmc.org/articles/PMC3493877
Autor:
Frank B. Hu, Ronald M. Evans, Lu Qi, Russell R. Nofsinger, Cem Z. Görgün, Sihao Liu, Chih-Hao Lee, Shannon M. Reilly, Prerna Bhargava, Matthew R. Gangl
Publikováno v:
Cell Metabolism. 12:643-653
SummaryThe transcriptional corepressor SMRT utilizes two major receptor-interacting domains (RID1 and RID2) to mediate nuclear receptor (NR) signaling through epigenetic modification. The physiological significance of such interaction remains unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ffaccdef9bc837231638e58c780ca8
https://doi.org/10.1016/j.cmet.2010.11.007
https://doi.org/10.1016/j.cmet.2010.11.007
Autor:
Volkan Karabacak, Kelly Fitzgerald, Ben Hatano, Shannon M. Reilly, Chih-Hao Lee, Kihwa Kang, Matthew R. Gangl
Publikováno v:
Cell Metabolism. 7:485-495
The polarization of adipose tissue-resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to improve insulin sensitivity. However, the mechanisms controlling tissue macrophage activation remain unclear. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4539763dd4c2166d1ba95d3333c287e0
https://doi.org/10.1016/j.cmet.2008.04.002
https://doi.org/10.1016/j.cmet.2008.04.002
Autor:
Chih-Hao Lee, Ling Qi, David Jacobi, Lingling Dai, Hang Shi, Karen Inouye, Sihao Liu, Kristopher J. Stanya, Joseph P. Mizgerd, Matthew R. Gangl, Yewei Ji, Jillian Barlow, Prerna Bhargava, Andrew Neil James Mckenzie
Hyperglycemia is a result of impaired insulin action on glucose production and disposal, and a major target of antidiabetic therapies. The study of insulin-independent regulatory mechanisms of glucose metabolism may identify new strategies to lower b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87eda614c59d9475edc84da66479810
https://europepmc.org/articles/PMC3533296/
https://europepmc.org/articles/PMC3533296/
Autor:
Minghui Zhao, Chen-Chung Yen, Ben Hatano, Chih-Hao Lee, James M. Ntambi, Sihao Liu, Shannon M. Reilly, Matthew R. Gangl, Kihwa Kang, James A. Balschi, Cem Z. Görgün
Pharmacological activation of peroxisome proliferator-activated receptor δ/β (PPARδ/β) improves glucose handling and insulin sensitivity. The target tissues of drug actions remain unclear. We demonstrate here that adenovirus-mediated liver-restri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01dd70bffcddffdb574b6fff2f8d059b
https://europepmc.org/articles/PMC3020731/
https://europepmc.org/articles/PMC3020731/