Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Matthew R. Box"'
Autor:
Jennifer E. Nelson, Graeme R. Robb, Martin R. Howard, Piotr Raubo, Paul D. Kemmitt, Kevin Blades, Junjie Shi, Tony Cheung, Qing Cao, Peter Barton, Andrew D. Ferguson, D. Bryan Prince, Shaun M. Fillery, Jun Hu, David J. Hargreaves, Roman D. Abrams, Nathan O. Fuller, Claudio Chuaqui, Eric Gangl, Matthew R. Box, Ning Gao, William McCoull, Kate Byth, Michael J. Waring, Jonathan Burgess, Xiahui Zhu, Matthew Grist, Erica Anderson, Nichole O'Connell, Philip B. Rawlins, Marta Wylot, David Whittaker, Rodrigo J. Carbajo, Erin Code
Publikováno v:
Journal of medicinal chemistry. 60(10)
Inhibition of the protein-protein interaction between B-cell lymphoma 6 (BCL6) and corepressors has been implicated as a therapeutic target in diffuse large B-cell lymphoma (DLBCL) cancers and profiling of potent and selective BCL6 inhibitors are cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208040f32aed94f8aa4f242f2c50c2a7
https://pubmed.ncbi.nlm.nih.gov/28714680
https://pubmed.ncbi.nlm.nih.gov/28714680
Autor:
Katrina S. Madden, Kevin Blades, Gillian M. Lamont, Matthew R. Box, Paul D. Kemmitt, William McCoull, Stephanie Dickinson, Jason D. Williams
Publikováno v:
The Journal of Organic Chemistry. 79:7682-7688
A new synthetic route to 3-(heteroaryl) tetrahydropyrazolo[3,4-c]pyridines has been developed that uses the Suzuki-Miyaura cross-coupling of a triflate 6 with (hetero)aryl boronic acids or esters. Using Pd(OAc)2 and XPhos or an XPhos precatalyst, a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421996275e7367a5db955afe3edaafdf
https://doi.org/10.1021/jo5012015
https://doi.org/10.1021/jo5012015
Publikováno v:
Synlett. 25:123-127
A range of useful disubstituted benzyl alcohol building blocks have been synthesised in multigram quantities in a lithium–bromide exchange to give aldehyde, carboxylic acid and pinacol boranes in high yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8be52774626e6397444cbe620ea160a1
https://doi.org/10.1055/s-0033-1340069
https://doi.org/10.1055/s-0033-1340069
Autor:
Clare Lane, Nicola Colclough, Les A. Dakin, M. Raymond V. Finlay, Claudio Chuaqui, Mark J. Anderton, Christopher G. Chorley, Matthew Grist, Darren Cross, Richard A. Ward, Michael J. Waring, Teresa Klinowska, Jonathon P. Orme, Cath Eberlein, Judit E. Debreczeni, Scott W. Martin, Matthew R. Box, Peter D. Smith, Susan Ashton, Paul A. Bethel, Fengjiang Wang, Sam Butterworth, George B. Hill
Publikováno v:
Journal of Medicinal Chemistry. 56:7025-7048
A novel series of small-molecule inhibitors has been developed to target the double mutant form of the epidermal growth factor receptor (EGFR) tyrosine kinase, which is resistant to treatment with gefitinib and erlotinib. Our reported compounds also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237e19427658906a39a69db96dfe94d1
https://doi.org/10.1021/jm400822z
https://doi.org/10.1021/jm400822z
Autor:
Pasi A. Jänne, Zhenfan Yang, Matthew R. Box, Dong Wan Kim, Matthew Grist, Mireille Cantarini, Angela Jordan, Peter Johnström, Peter Ballard, James Chih-Hsin Yang, Michael J. Hickey, Darren Cross, James W.T. Yates, Kenneth S. Thress, Jonas Malmquist, Kathryn Pickup, Katarina Varnäs
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(20)
Purpose: Approximately one-third of patients with non–small cell lung cancer (NSCLC) harboring tumors with EGFR-tyrosine kinase inhibitor (TKI)-sensitizing mutations (EGFRm) experience disease progression during treatment due to brain metastases. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abd44cd1ee6732fad8f3711fbbf7296
https://pubmed.ncbi.nlm.nih.gov/27435396
https://pubmed.ncbi.nlm.nih.gov/27435396
Autor:
Kevin Blades, Paul D. Kemmitt, William McCoull, Stephanie Dickinson, Jason D. Williams, Gillian M. Lamont, Matthew R. Box, Katrina S. Madden
Publikováno v:
ChemInform. 46
A new synthetic route to 3-(heteroaryl) tetrahydropyrazolo[3,4-c]pyridines has been developed that uses the Suzuki–Miyaura cross-coupling of a triflate 6 with (hetero)aryl boronic acids or esters. Using Pd(OAc)2 and XPhos or an XPhos precatalyst, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::497777ea27c5a8492998fb8c8f3a9f2d
https://doi.org/10.1002/chin.201508232
https://doi.org/10.1002/chin.201508232
Autor:
Peter Ballard, Michael James, Daniel S. James, Peter D. Smith, Simon J. Brown, M. Raymond V. Finlay, Michael J. Waring, Paula Perkins, Andrew D. Campbell, Heather L. McFarland, David Perkins, Gordon S. Currie, Gillian M. Lamont, Graham Richmond, Matthew R. Box, David Whittaker, Mark J. Anderton, Richard A. Ward, Teresa Klinowska, Scott G. Lamont, Nicola Colclough, Stuart L. Wells, Darren Cross, Gail L. Wrigley, George B. Hill, Nathaniel G. Martin, Paul D. Kemmitt, Susan Ashton, Lorraine A. Hassall, Paul A. Bethel, Robert Hugh Bradbury, Sam Butterworth, Christopher G. Chorley, Martine J. Mellor, Matthew Grist, Jonathon P. Orme
Publikováno v:
Journal of medicinal chemistry. 57(20)
Epidermal growth factor receptor (EGFR) inhibitors have been used clinically in the treatment of non-small-cell lung cancer (NSCLC) patients harboring sensitizing (or activating) mutations for a number of years. Despite encouraging clinical efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9360f89f601b2e2e19d1acdd90f2bb
https://pubmed.ncbi.nlm.nih.gov/25271963
https://pubmed.ncbi.nlm.nih.gov/25271963
Autor:
Julius Tibbelin, Jonathan D. Sellars, Michal Czyzewski, Patrick G. Steel, Tamaz Guliashvili, Lisa Johnstone, Henrik Ottosson, Matthew R. Box, Robert D. M. Davies, Justin Bower
Publikováno v:
ChemInform. 45
A derivative of (Ia) with a methyl-substituent at the terminal double bond yields no cycloadduct under the presented conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::320866f2dc06757b33849042b2a8c32c
https://doi.org/10.1002/chin.201428189
https://doi.org/10.1002/chin.201428189
Publikováno v:
ChemInform. 45
A range of useful disubstituted benzyl alcohol building blocks have been synthesised in multigram quantities in a lithium–bromide exchange to give aldehyde, carboxylic acid and pinacol boranes in high yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1958ebb925d8817c4917f2de8d8ca3f
https://doi.org/10.1002/chin.201424045
https://doi.org/10.1002/chin.201424045
Autor:
Michal Czyzewski, Justin Bower, Patrick G. Steel, Robert D. M. Davies, Julius Tibbelin, Matthew R. Box, Lisa Johnstone, Henrik Ottosson, Tamaz Guliashvili, Jonathan D. Sellars
Publikováno v:
Chemical communications, 2014, Vol.50(22), pp.2919-2921 [Peer Reviewed Journal]
The synthesis of silaheterocycles through the first examples of an intramolecular silene Diels-Alder reaction is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac335446ed133d93321393c2ab0c897c
http://dro.dur.ac.uk/12062/
http://dro.dur.ac.uk/12062/
