Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Matthew R Markovetz"'
Autor:
Kaitlyn R Rouillard, Christopher P Esther, William J Kissner, Lucas M Plott, Dean W Bowman, Matthew R Markovetz, David B Hill
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0294120 (2024)
People with muco-obstructive pulmonary diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) often have acute or chronic respiratory infections that are difficult to treat due in part to the accumulation of hyperconce
Externí odkaz:
https://doaj.org/article/72bb598001344edaa99e0f9f178812c0
Autor:
Matthew R Markovetz, Timothy E Corcoran, Landon W Locke, Michael M Myerburg, Joseph M Pilewski, Robert S Parker
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111972 (2014)
Cystic Fibrosis (CF) lung disease is characterized by liquid hyperabsorption, airway surface dehydration, and impaired mucociliary clearance (MCC). Herein, we present a compartment-based mathematical model of the airway that extends the resolution of
Externí odkaz:
https://doaj.org/article/937e18d4281a4075a5934e82816ae98f
Publikováno v:
mSphere, Vol 7, Iss 4 (2022)
ABSTRACT The pathological properties of airway mucus in cystic fibrosis (CF) are dictated by mucus concentration and composition, with mucins and DNA being responsible for mucus viscoelastic properties. As CF pulmonary disease progresses, the concent
Externí odkaz:
https://doaj.org/article/c90a0a37058d42b885c7d2990e83176b
Autor:
Laura A. Hancock, Corinne E. Hennessy, George M. Solomon, Evgenia Dobrinskikh, Alani Estrella, Naoko Hara, David B. Hill, William J. Kissner, Matthew R. Markovetz, Diane E. Grove Villalon, Matthew E. Voss, Guillermo J. Tearney, Kate S. Carroll, Yunlong Shi, Marvin I. Schwarz, William R. Thelin, Steven M. Rowe, Ivana V. Yang, Christopher M. Evans, David A. Schwartz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The promoter variant rs35705950 confers a gain of function to the MUC5B gene and is the dominant risk factor for idiopathic pulmonary fibrosis. Here the authors show that mice overexpressing Muc5b in distal airspaces show impaired mucociliary clearan
Externí odkaz:
https://doaj.org/article/179e7c61d4b74fa68c0ec80470732ff6
Autor:
Matthew R. Markovetz, Ian C. Garbarine, Cameron B. Morrison, William J. Kissner, Ian Seim, M. Gregory Forest, Micah J. Papanikolas, Ronit Freeman, Agathe Ceppe, Andrew Ghio, Neil E. Alexis, Stephen M. Stick, Camille Ehre, Richard C. Boucher, Charles R. Esther, Marianne S. Muhlebach, David B. Hill
Publikováno v:
Journal of Cystic Fibrosis. 21:959-966
Mucus hyperconcentration in cystic fibrosis (CF) lung disease is marked by increases in both mucin and DNA concentration. Additionally, it has been shown that half of the mucins present in bronchial alveolar lavage fluid (BALF) from preschool-aged CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d562eb564d7ab44b49b3eecdcbe0ec29
https://doi.org/10.1016/j.jcf.2022.04.008
https://doi.org/10.1016/j.jcf.2022.04.008
Autor:
Kaitlyn R. Rouillard, Matthew R. Markovetz, William J. Kissner, William L. Boone, Lucas M. Plott, David B. Hill
Publikováno v:
Biofilm. 5:100104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b83ec5b31882d5af93f6432109d4a0b4
https://doi.org/10.1016/j.bioflm.2023.100104
https://doi.org/10.1016/j.bioflm.2023.100104
Autor:
Matthew R. Markovetz, Jacob E. Hibbard, Lucas M. Plott, Lawrence G. Bacudio, William J. Kissner, Andrew Ghio, Priya A. Kumar, Harendra Arora, David B. Hill
Publikováno v:
Frontiers in Physiology. 14
Across the globe, millions of people are affected by muco-obstructive pulmonary diseases like cystic fibrosis, asthma, and chronic obstructive pulmonary disease. In MOPDs, the airway mucus becomes hyperconcentrated, increasing viscoelasticity and imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a637522e7fc162ede6dfa454448f1e7
https://doi.org/10.3389/fphys.2023.1111647
https://doi.org/10.3389/fphys.2023.1111647
Autor:
Efrat Ozeri-Galai, Lital Friedman, null Ofra-Barchad-Avitzur, Matthew R Markovetz, William Boone, Kaitlyn R Rouillard, Chava D Stampfer, Yifat S Oren, David B Hill, Batsheva Kerem, Gili Hart
The last years have shown enormous advancement in the therapeutic potential of RNA-related treatments, specifically for antisense oligonucleotide (ASO)-based drugs, leading to increased numbers of ASO regulatory approvals. In this study we focus on S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0633060cb2f46556fe1d306a533247ba
https://doi.org/10.1101/2023.01.09.23284328
https://doi.org/10.1101/2023.01.09.23284328
Autor:
Lawrence E. Ostrowski, Matthew R. Markovetz, Richard Superfine, Henry Gong, Ximena M. Bustamante-Marin, Patrick R. Sears, David B. Hill
Publikováno v:
Biophysical Journal. 120:1387-1395
Impaired mucociliary clearance (MCC) is a key feature of many airway diseases, including asthma, bronchiectasis, chronic obstructive pulmonary disease, cystic fibrosis, and primary ciliary dyskinesia. To improve MCC and develop new treatments for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4069b560660922354c453d1b8adafd55
https://doi.org/10.1016/j.bpj.2021.01.041
https://doi.org/10.1016/j.bpj.2021.01.041
Autor:
Camille Ehre, Scott H. Donaldson, Matthieu Robert de Saint Vincent, Jérémy Patarin, Matthew R. Markovetz, Kenza C. Araba, Kendall M. Shaffer, Jason A. Wykoff
Publikováno v:
Journal of visualized experiments : JoVE. (182)
In muco-obstructive lung diseases (e.g., asthma, chronic obstructive pulmonary disease, cystic fibrosis) and other respiratory conditions (e.g., viral/bacterial infections), mucus biophysical properties are altered by goblet cell hypersecretion, airw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c81ea38c044cde08dbc9381bcb63e40
https://pubmed.ncbi.nlm.nih.gov/35532240
https://pubmed.ncbi.nlm.nih.gov/35532240