Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Matthew R Lincoln"'
Autor:
Sreeram V Ramagopalan, Andrew P Morris, David A Dyment, Blanca M Herrera, Gabriele C DeLuca, Matthew R Lincoln, Sarah M Orton, Michael J Chao, A Dessa Sadovnick, George C Ebers
Publikováno v:
PLoS Genetics, Vol 3, Iss 9, Pp 1607-1613 (2007)
Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. HLA-DRB1*15 and HLA-DRB1*17-bearing haplotypes and interactions at the HLA-DRB1 locus increase ri
Externí odkaz:
https://doaj.org/article/ad8d63e5ccb14b6095f3b074af48426f
Autor:
Sreeram V Ramagopalan, Narelle J Maugeri, Lahiru Handunnetthi, Matthew R Lincoln, Sarah-Michelle Orton, David A Dyment, Gabriele C Deluca, Blanca M Herrera, Michael J Chao, A Dessa Sadovnick, George C Ebers, Julian C Knight
Publikováno v:
PLoS Genetics, Vol 5, Iss 2, p e1000369 (2009)
Multiple sclerosis (MS) is a complex trait in which allelic variation in the MHC class II region exerts the single strongest effect on genetic risk. Epidemiological data in MS provide strong evidence that environmental factors act at a population lev
Externí odkaz:
https://doaj.org/article/77bcebfcdb4646078140204a1f5791b8
Autor:
Janna Saarela, Suvi P Kallio, Daniel Chen, Alexandre Montpetit, Anne Jokiaho, Eva Choi, Rosanna Asselta, Denis Bronnikov, Matthew R Lincoln, A Dessa Sadovnick, Pentti J Tienari, Keijo Koivisto, Aarno Palotie, George C Ebers, Thomas J Hudson, Leena Peltonen
Publikováno v:
PLoS Genetics, Vol 2, Iss 3, p e42 (2006)
Multiple sclerosis (MS) is a chronic disease of the central nervous system responsible for a large portion of neurological disabilities in young adults. Similar to what occurs in numerous complex diseases, both unknown environmental factors and genet
Externí odkaz:
https://doaj.org/article/a69d4790ba4a44f8914d498c270be99d
Autor:
Pierre-Paul Axisa, Tomomi M. Yoshida, Liliana E. Lucca, Herbert G. Kasler, Matthew R. Lincoln, Giang H. Pham, Dante Del Priore, Jean-Marie Carpier, Carrie L. Lucas, Eric Verdin, Tomokazu S. Sumida, David A. Hafler
Publikováno v:
Science Translational Medicine. 14
Genome-wide association studies identifying hundreds of susceptibility loci for autoimmune diseases indicate that genes active in immune cells predominantly mediate risk. However, identification and functional characterization of causal variants rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f8de95d5734d2cbadf4b1e643cb5eb
https://doi.org/10.1126/scitranslmed.abl3651
https://doi.org/10.1126/scitranslmed.abl3651
Autor:
Tomokazu S. Sumida, Matthew R. Lincoln, Liang He, Yongjin Park, Mineto Ota, Helen A. Stillwell, Greta A. Leissa, Keishi Fujio, Alexander M. Kulminski, Charles B. Epstein, Bradley E. Bernstein, Manolis Kellis, David A. Hafler
Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. While CD4+Foxp3+regulatory T cells (Tregs) play a central role in preventing autoimmunity, the molecular mechanism underlying the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7b18add77bf4924b98ce2e9c66a1abd
https://doi.org/10.1101/2022.12.02.518871
https://doi.org/10.1101/2022.12.02.518871
Publikováno v:
Current Opinion in Immunology. 67:50-56
Genome-wide association studies (GWAS) have identified genetic susceptibility loci for a variety of autoimmune and inflammatory diseases. These studies confirm the fundamental genetic basis of individual autoimmune diseases, and also point to shared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b12f100073ea4ce263f556b7dbacf6
https://doi.org/10.1016/j.coi.2020.09.002
https://doi.org/10.1016/j.coi.2020.09.002
Autor:
David Pitt, Chih Hung Lo, Susan A. Gauthier, Richard A. Hickman, Erin Longbrake, Laura M. Airas, Yang Mao-Draayer, Claire Riley, Philip Lawrence De Jager, Sarah Wesley, Aaron Boster, Ilir Topalli, Francesca Bagnato, Mohammad Mansoor, Olaf Stuve, Ilya Kister, Daniel Pelletier, Panos Stathopoulos, Ranjan Dutta, Matthew R. Lincoln
The classification of multiple sclerosis (MS) has been established by Lublin in 1996 and revised in 2013. The revision includes clinically isolated syndrome, relapsing-remitting, primary progressive and secondary progressive MS, and has added activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2933ec0d7474875f4072a56d76bebd
https://hdl.handle.net/10356/164428
https://hdl.handle.net/10356/164428
Publikováno v:
Expert Review of Clinical Immunology. 17:691-693
Vitamin D insufficiency is implicated in multiple sclerosis (MS) susceptibility, but evidence for a direct disease-modifying effect remains limited. We review evidence that vitamin D drives MS risk...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089474f3403fec51e3d386cce452db10
https://doi.org/10.1080/1744666x.2021.1915772
https://doi.org/10.1080/1744666x.2021.1915772
Autor:
Leonid Padyukov, R. R. Graham, Chris Cotsapas, Mitja Mitrovic, Sung Chun, Matthew R Lincoln, David A. Hafler, Patrick M. Gaffney, Connally N, Carl D. Langefeld, Heel Dv, Cisca Wijmenga, Christiane Gasperi, Sunayev, Iris Jonkers, Pierre-Paul Axisa, Sebo Withoff, Stephen S. Rich
Autoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but the limited resolution of genetic mapping prevents determining if the same allele is responsible, indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f7695945875875467cd6f77be1e447
https://doi.org/10.1101/2021.05.13.21257044
https://doi.org/10.1101/2021.05.13.21257044
Autor:
Matthew R Lincoln, Pierre-Paul Axisa, Naftali Kaminski, Avraham Unterman, Michela Comi, David A. Hafler, Shai Dulberg, Asaf Madi, Jonas C. Schupp, Vijay K. Kuchroo, Tomokazu Sumida, Helen A Stillwell
Publikováno v:
Research Square
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
While inhibition of T cell co-inhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. Type 1 interferon (IFN-I) modulates T cell immunity in viral infection, autoimm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8afa88e6d6b78fe83f17c48a780f3ad
https://pubmed.ncbi.nlm.nih.gov/34127967
https://pubmed.ncbi.nlm.nih.gov/34127967