Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Matthew R Karolak"'
Autor:
J Preston Campbell, Matthew R Karolak, Yun Ma, Daniel S Perrien, S Kathryn Masood-Campbell, Niki L Penner, Steve A Munoz, Andries Zijlstra, Xiangli Yang, Julie A Sterling, Florent Elefteriou
Publikováno v:
PLoS Biology, Vol 10, Iss 7, p e1001363 (2012)
Bone and lung metastases are responsible for the majority of deaths in patients with breast cancer. Following treatment of the primary cancer, emotional and psychosocial factors within this population precipitate time to recurrence and death, however
Externí odkaz:
https://doaj.org/article/e5a97d066b954491a30c186e5aa93c1b
Autor:
Xiangli Yang, Weixi Wang, Jean de la Croix Ndong, Matthew R. Karolak, Koichiro Ono, Florent Elefteriou
Publikováno v:
Human Molecular Genetics. 22:3048-3062
The severe defects in growth plate development caused by chondrocyte extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) gain or loss-of-function suggest that tight spatial and temporal regulation of mitogen-activated protein kinase signa
Autor:
Andries Zijlstra, Florent Elefteriou, Matthew R. Karolak, J. Preston Campbell, Patrick L. Mulcrone, S. K. Masood, Julie A. Sterling, Katie E. Hebron, Alyssa R. Merkel
Publikováno v:
Scientific Reports
Current methods for detecting disseminated tumor cells in the skeleton are limited by expense and technical complexity. We describe a simple and inexpensive method to quantify, with single cell sensitivity, human metastatic cancer in the mouse skelet
Publikováno v:
Human molecular genetics. 24(9)
Aberrant fibroblast growth factor receptor 3 (FGFR3) signaling disrupts chondrocyte proliferation and growth plate size and architecture, leading to various chondrodysplasias or bone overgrowth. These observations suggest that the duration, intensity
Autor:
Robert T. Dorr, Matthew R. Karolak, Ryan McGrath, Aluvia M. Escalante, Ronald M. Lynch, Terry H. Landowski
Publikováno v:
Cancer chemotherapy and pharmacology. 71(6)
Bortezomib, a first-generation proteasome inhibitor, induces an endoplasmic reticulum (ER) stress response, which ultimately leads to dysregulation of intracellular Ca(2+) and apoptotic cell death. This study investigated the role of the Ca(2+)-depen
Autor:
Niki Penner, S. Kathryn Masood-Campbell, Xiangli Yang, Julie A. Sterling, J. Preston Campbell, Matthew R. Karolak, Steve Munoz, Florent Elefteriou, Andries Zijlstra, Daniel S. Perrien, Yun-Yun Ma
Publikováno v:
PLoS Biology, Vol 10, Iss 7, p e1001363 (2012)
PLoS Biology
PLoS Biology
The activation of sympathetic nerves by psychosocial stress creates a favorable environment in bone for the establishment of cancer cells in a mouse model of breast cancer.
Bone and lung metastases are responsible for the majority of deaths in p
Bone and lung metastases are responsible for the majority of deaths in p
Autor:
Meredith C. Henderson, Matthew R. Karolak, Terry H. Landowski, Ryan McGrath, Georgia O. Perrian, Ronald M. Lynch, Aluvia M. Escalante
Publikováno v:
Cancer Research. 71:2643-2643
The proteasome is a multi-subunit enzyme complex that plays a central role in the regulation of proteins controlling many important cellular functions including cell cycle progression, differentiation, gene transcription and apoptosis. Bortezomib is