Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Matthew R Brown"'
Autor:
Matthew R. Brown, Damien Laouteouet, Morgane Delobel, Orianne Villard, Christophe Broca, Gyslaine Bertrand, Anne Wojtusciszyn, Stéphane Dalle, Magalie A. Ravier, Aleksey V. Matveyenko, Safia Costes
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-12 (2022)
Abstract Pancreatic β-cell failure in type 2 diabetes mellitus (T2DM) is associated with impaired regulation of autophagy which controls β-cell development, function, and survival through clearance of misfolded proteins and damaged organelles. Howe
Externí odkaz:
https://doaj.org/article/b8f90d9713164bc79d87bd9e85ebe040
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Our ever-changing modern environment is a significant contributor to the increased prevalence of many chronic diseases, and particularly, type 2 diabetes mellitus (T2DM). Although the modern era has ushered in numerous changes to our daily living con
Externí odkaz:
https://doaj.org/article/7071ef5e69254d55bf1fe613c02d333b
Autor:
Quinn P. Peterson, Adrian Veres, Lihua Chen, Michael Q. Slama, Jennifer H. R. Kenty, Shaimaa Hassoun, Matthew R. Brown, Haiqiang Dou, Caden D. Duffy, Quan Zhou, Aleksey V. Matveyenko, Björn Tyrberg, Maria Sörhede-Winzell, Patrik Rorsman, Douglas A. Melton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Deriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression
Externí odkaz:
https://doaj.org/article/6faab0e582834b4a8aca6528596abca2
Autor:
Naureen Javeed, Tracy K. Her, Matthew R. Brown, Patrick Vanderboom, Kuntol Rakshit, Aoife M. Egan, Adrian Vella, Ian Lanza, Aleksey V. Matveyenko
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109613- (2021)
Summary: Coordinated communication among pancreatic islet cells is necessary for maintenance of glucose homeostasis. In diabetes, chronic exposure to pro-inflammatory cytokines has been shown to perturb β cell communication and function. Compelling
Externí odkaz:
https://doaj.org/article/f6142bb336574cc9a398c46f3da9ef28
Autor:
Sean A Briceno, Matthew R Brown, Andrew B Herson, Steven T Fischer, Kevin D Healey, Brooke T Miller, Michael W. Fountain
Publikováno v:
Cureus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acd0ec5dce278e59a70b4614f30c7ffe
https://doi.org/10.7759/cureus.38217
https://doi.org/10.7759/cureus.38217
Autor:
Nicolas Wieder, Juliana Coraor Fried, Choah Kim, Eriene-Heidi Sidhom, Matthew R. Brown, Jamie L. Marshall, Carlos Arevalo, Moran Dvela-Levitt, Maria Kost-Alimova, Jonas Sieber, Katlyn R. Gabriel, Julian Pacheco, Clary Clish, Hamdah Shafqat Abbasi, Shantanu Singh, Justine Rutter, Martine Therrien, Haejin Yoon, Zon Weng Lai, Aaron Baublis, Renuka Subramanian, Ranjan Devkota, Jonnell Small, Vedagopuram Sreekanth, Myeonghoon Han, Donghyun Lim, Anne E. Carpenter, Jason Flannick, Hilary Finucane, Marcia C. Haigis, Melina Claussnitzer, Eric Sheu, Beth Stevens, Bridget K. Wagner, Amit Choudhary, Jillian L. Shaw, Juan Lorenzo Pablo, Anna Greka
Publikováno v:
bioRxiv
SummaryCellular exposure to free fatty acids (FFA) is implicated in the pathogenesis of obesity-associated diseases. However, studies to date have assumed that a few select FFAs are representative of broad structural categories, and there are no scal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7daa44ca6aa3c52a2ff38c29c3f14b60
https://doi.org/10.1101/2023.02.19.529127
https://doi.org/10.1101/2023.02.19.529127
Autor:
Raquel Orozco, Matthew R. Brown
Publikováno v:
Biotechnology and Bioengineering. 118:3367-3374
As part of a viral mitigating strategy for continuous bioprocessing, that utilizes a plug flow reactor (PFR) for continuous viral inactivation (CVI), understanding the minimum residence time as a function of reactor scale and operational conditions i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1bb21b85296924a593f6dfc960ed10
https://doi.org/10.1002/bit.27734
https://doi.org/10.1002/bit.27734
Autor:
Areonna C. Schreiber, Adam J. Rossano, Carmen J. Reynolds, Heather L. Holmes, Matthew R. Brown, Aleksey Matveyenko, Michael F. Romero
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cfa10c2b142bf42505ed98e7e48e06f
https://doi.org/10.1096/fasebj.2022.36.s1.r5425
https://doi.org/10.1096/fasebj.2022.36.s1.r5425
Autor:
Quan Zhou, Maria Sörhede-Winzell, Douglas A. Melton, Shaimaa Hassoun, Jennifer H. R. Kenty, Aleksey V. Matveyenko, Matthew R. Brown, Caden D. Duffy, Adrian Veres, Björn Tyrberg, Patrik Rorsman, Michael Q. Slama, Lihua Chen, Quinn P. Peterson, Haiqiang Dou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The generation of pancreatic cell types from renewable cell sources holds promise for cell replacement therapies for diabetes. Although most effort has focused on generating pancreatic beta cells, considerable evidence indicates that glucagon secreti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1830555d671cc5d40102c6a337558a27
https://doaj.org/article/6faab0e582834b4a8aca6528596abca2
https://doaj.org/article/6faab0e582834b4a8aca6528596abca2
Autor:
Michael F. Romero, Y. S. Prakash, Satish Sen, Gary E. Shull, Matthew R. Brown, Alison A. Stiller, Aleksey V. Matveyenko, Heather L. Holmes, Naureen Javeed, Kuntol Rakshit, Tracy K. Her
Publikováno v:
J Clin Invest
Pancreatic β cell failure in type 2 diabetes mellitus (T2DM) is attributed to perturbations of the β cell’s transcriptional landscape resulting in impaired glucose-stimulated insulin secretion. Recent studies identified SLC4A4 (a gene encoding an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623cb5ac371912498eaf1c803d9f5b61
https://doi.org/10.1172/jci142365
https://doi.org/10.1172/jci142365