Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Matthew R Bennett"'
Publikováno v:
BMJ Open, Vol 11, Iss 12 (2021)
Objectives Reform of England’s social care system is repeatedly discussed in the context of increasing demand, rising costs and austere policies that have decreased service provision. This study investigates the association between unpaid carers’
Externí odkaz:
https://doaj.org/article/0a998ceb6ad8468b9ab1533fb05c00b5
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009381 (2021)
The increased complexity of synthetic microbial biocircuits highlights the need for distributed cell functionality due to concomitant increases in metabolic and regulatory burdens imposed on single-strain topologies. Distributed systems, however, int
Externí odkaz:
https://doaj.org/article/b5d3e5a515724a449fca718d2c8ac1d0
Autor:
Marcin Budka, Matthew R Bennett, Sally C Reynolds, Shelby Barefoot, Sarah Reel, Selina Reidy, Jeremy Walker
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255630 (2021)
Footprints are left, or obtained, in a variety of scenarios from crime scenes to anthropological investigations. Determining the sex of a footprint can be useful in screening such impressions and attempts have been made to do so using single or multi
Externí odkaz:
https://doaj.org/article/b9eeca9929ad4e79b38ee8721fea0841
Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer
Autor:
Anisha M Perez, Marcella M Gomez, Prashant Kalvapalle, Erin O'Brien‐Gilbert, Matthew R Bennett, Yousif Shamoo
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 12, Pp 1-16 (2017)
Abstract The major facilitator superfamily (MFS) effluxers are prominent mediators of antimicrobial resistance. The biochemical characterization of MFS proteins is hindered by their complex membrane environment that makes in vitro biochemical analysi
Externí odkaz:
https://doaj.org/article/982ed8ef8fba41cf86a73940ff00ed00
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-11 (2010)
Abstract Systems biology can offer a great deal of insight into evolution by quantitatively linking complex properties such as protein structure, folding, and function to the fitness of an organism. Although the link between diseases such as Alzheime
Externí odkaz:
https://doaj.org/article/462318ae2c134908aca7021d8980ba09
Publikováno v:
Molecular Systems Biology, Vol 3, Iss 1, Pp 1-5 (2007)
Abstract Protein decay rates are regulated by degradation machinery that clears unnecessary housekeeping proteins and maintains appropriate dynamic resolution for transcriptional regulators. Turnover rates are also crucial for fluorescence reporters
Externí odkaz:
https://doaj.org/article/3e81a3cb89a949f58d4f819f52112cf3
Autor:
Alan Veliz-Cuba, Andrew J Hirning, Adam A Atanas, Faiza Hussain, Flavia Vancia, Krešimir Josić, Matthew R Bennett
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 12, p e1004674 (2015)
Synthetic gene oscillators are small, engineered genetic circuits that produce periodic variations in target protein expression. Like other gene circuits, synthetic gene oscillators are noisy and exhibit fluctuations in amplitude and period. Understa
Externí odkaz:
https://doaj.org/article/d488803f994b4677a60985eda0d0a322
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 7, p e1004399 (2015)
Modulation of gene network activity allows cells to respond to changes in environmental conditions. For example, the galactose utilization network in Saccharomyces cerevisiae is activated by the presence of galactose but repressed by glucose. If both
Externí odkaz:
https://doaj.org/article/9bca81b45f8641919194704fc3397088
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60755 (2013)
Human footprints provide some of the most publically emotive and tangible evidence of our ancestors. To the scientific community they provide evidence of stature, presence, behaviour and in the case of early hominins potential evidence with respect t
Externí odkaz:
https://doaj.org/article/609c4d0633514397aa005e55b6f22b7b
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 4, p e1002480 (2012)
Gene expression actualizes the organismal phenotypes encoded within the genome in an environment-dependent manner. Among all encoded phenotypes, cell population growth rate (fitness) is perhaps the most important, since it determines how well-adapted
Externí odkaz:
https://doaj.org/article/70fa809107b74923ae2b472a7307004b