Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Matthew R, Plumb"'
Autor:
Nicholas F G Chen, Chrispin Chaguza, Luc Gagne, Matthew Doucette, Sandra Smole, Erika Buzby, Joshua Hall, Stephanie Ash, Rachel Harrington, Seana Cofsky, Selina Clancy, Curtis J Kapsak, Joel Sevinsky, Kevin Libuit, Daniel J Park, Peera Hemarajata, Jacob M Garrigues, Nicole M Green, Sean Sierra-Patev, Kristin Carpenter-Azevedo, Richard C Huard, Claire Pearson, Kutluhan Incekara, Christina Nishimura, Jian Ping Huang, Emily Gagnon, Ethan Reever, Jafar Razeq, Anthony Muyombwe, Vítor Borges, Rita Ferreira, Daniel Sobral, Silvia Duarte, Daniela Santos, Luís Vieira, João Paulo Gomes, Carly Aquino, Isabella M Savino, Karinda Felton, Moneeb Bajwa, Nyjil Hayward, Holly Miller, Allison Naumann, Ria Allman, Neel Greer, Amary Fall, Heba H Mostafa, Martin P McHugh, Daniel M Maloney, Rebecca Dewar, Juliet Kenicer, Abby Parker, Katharine Mathers, Jonathan Wild, Seb Cotton, Kate E Templeton, George Churchwell, Philip A Lee, Maria Pedrosa, Brenna McGruder, Sarah Schmedes, Matthew R Plumb, Xiong Wang, Regina Bones Barcellos, Fernanda M S Godinho, Richard Steiner Salvato, Aimee Ceniseros, Mallery I Breban, Nathan D Grubaugh, Glen R Gallagher, Chantal B F Vogels
Publikováno v:
PLoS Biology, Vol 21, Iss 6, p e3002151 (2023)
The 2022 multicountry mpox outbreak concurrent with the ongoing Coronavirus Disease 2019 (COVID-19) pandemic further highlighted the need for genomic surveillance and rapid pathogen whole-genome sequencing. While metagenomic sequencing approaches hav
Externí odkaz:
https://doaj.org/article/f6624948d6784e6da2c1bd198855dab0
Autor:
Nicholas F G, Chen, Chrispin, Chaguza, Luc, Gagne, Matthew, Doucette, Sandra, Smole, Erika, Buzby, Joshua, Hall, Stephanie, Ash, Rachel, Harrington, Seana, Cofsky, Selina, Clancy, Curtis J, Kapsak, Joel, Sevinsky, Kevin, Libuit, Daniel J, Park, Peera, Hemarajata, Jacob M, Garrigues, Nicole M, Green, Sean, Sierra-Patev, Kristin, Carpenter-Azevedo, Richard C, Huard, Claire, Pearson, Kutluhan, Incekara, Christina, Nishimura, Jian Ping, Huang, Emily, Gagnon, Ethan, Reever, Jafar, Razeq, Anthony, Muyombwe, Vítor, Borges, Rita, Ferreira, Daniel, Sobral, Silvia, Duarte, Daniela, Santos, Luís, Vieira, João Paulo, Gomes, Carly, Aquino, Isabella M, Savino, Karinda, Felton, Moneeb, Bajwa, Nyjil, Hayward, Holly, Miller, Allison, Naumann, Ria, Allman, Neel, Greer, Amary, Fall, Heba H, Mostafa, Martin P, McHugh, Daniel M, Maloney, Rebecca, Dewar, Juliet, Kenicer, Abby, Parker, Katharine, Mathers, Jonathan, Wild, Seb, Cotton, Kate E, Templeton, George, Churchwell, Philip A, Lee, Maria, Pedrosa, Brenna, McGruder, Sarah, Schmedes, Matthew R, Plumb, Xiong, Wang, Regina Bones, Barcellos, Fernanda M S, Godinho, Richard Steiner, Salvato, Aimee, Ceniseros, Mallery I, Breban, Nathan D, Grubaugh, Glen R, Gallagher, Chantal B F, Vogels
Publikováno v:
medRxiv : the preprint server for health sciences.
The 2022 multi-country monkeypox outbreak concurrent with the ongoing COVID-19 pandemic has further highlighted the need for genomic surveillance and pathogen whole genome sequencing. While metagenomic sequencing approaches have been used to sequence
Autor:
Nicholas F.G. Chen, Chrispin Chaguza, Luc Gagne, Matthew Doucette, Sandra Smole, Erika Buzby, Joshua Hall, Stephanie Ash, Rachel Harrington, Seana Cofsky, Selina Clancy, Curtis J. Kapsak, Joel Sevinsky, Kevin Libuit, Daniel J. Park, Peera Hemarajata, Jacob M. Garrigues, Nicole M. Green, Sean Sierra-Patev, Kristin Carpenter-Azevedo, Richard C. Huard, Claire Pearson, Kutluhan Incekara, Christina Nishimura, Jian Ping Huang, Emily Gagnon, Ethan Reever, Jafar Razeq, Anthony Muyombwe, Vítor Borges, Rita Ferreira, Daniel Sobral, Silvia Duarte, Daniela Santos, Luís Vieira, João Paulo Gomes, Carly Aquino, Isabella M. Savino, Karinda Felton, Moneeb Bajwa, Nyjil Hayward, Holly Miller, Allison Naumann, Ria Allman, Neel Greer, Amary Fall, Heba H. Mostafa, Martin P. McHugh, Daniel M. Maloney, Rebecca Dewar, Juliet Kenicer, Abby Parker, Katharine Mathers, Jonathan Wild, Seb Cotton, Kate E. Templeton, George Churchwell, Philip A. Lee, Maria Pedrosa, Brenna McGruder, Sarah Schmedes, Matthew R. Plumb, Xiong Wang, Regina Bones Barcellos, Fernanda M.S. Godinho, Richard Steiner Salvato, Aimee Ceniseros, Mallery I. Breban, Nathan D. Grubaugh, Glen R. Gallagher, Chantal B.F. Vogels
The 2022 multi-country monkeypox (mpox) outbreak concurrent with the ongoing COVID-19 pandemic has further highlighted the need for genomic surveillance and rapid pathogen whole genome sequencing. While metagenomic sequencing approaches have been use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c28b583984857d908847dbcd929754
https://doi.org/10.1101/2022.10.14.22280783
https://doi.org/10.1101/2022.10.14.22280783
Autor:
Erik Serrao, Frederic D. Bushman, Alan Engelman, Venkatasubramanian Dharmarajan, Ashley C. Hoyte, Alison Slaughter, Jacques J. Kessl, Patrick R. Griffin, James R. Fuchs, Matthew R. Plumb, Ross C. Larue, Mamuka Kvaratskhelia, Amit Sharma, Lei Feng
Publikováno v:
ACS Chemical Biology. 11:1313-1321
Allosteric HIV-1 integrase inhibitors (ALLINIs) have recently emerged as a promising class of antiretroviral agents and are currently in clinical trials. In infected cells, ALLINIs potently inhibit viral replication by impairing virus particle matura
LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes
Autor:
Stephen H. Hughes, James R. Iben, Parmit K. Singh, Andrea L. Ferris, Henry L. Levin, Hind J. Fadel, Xiaolin Wu, Mamuka Kvaratskhelia, Caroline Esnault, Brian T. Luke, Eric M. Poeschla, Matthew R. Plumb
Publikováno v:
Genes & Development. 29:2287-2297
The host chromatin-binding factor LEDGF/p75 interacts with HIV-1 integrase and directs integration to active transcription units. To understand how LEDGF/p75 recognizes transcription units, we sequenced 1 million HIV-1 integration sites isolated from
Autor:
G. V. T. Swapna, Sriram Aiyer, Nirav Malani, Frederic D. Bushman, Matthew R. Plumb, James M. Aramini, William M. Schneider, Monica J. Roth, Mustafa H. Ghanem, Barbara Studamire, Ross C. Larue, Amit Sharma, Mamuka Kvaratskhelia, Gaetano T. Montelione
Publikováno v:
Nucleic Acids Research
We report alterations to the murine leukemia virus (MLV) integrase (IN) protein that successfully result in decreasing its integration frequency at transcription start sites and CpG islands, thereby reducing the potential for insertional activation.
Autor:
Amit Sharma, Matthew R. Plumb, Frederic D. Bushman, Julia V. DiFiore, Nikoloz Shkriabai, Monica J. Roth, Ross C. Larue, Nirav Malani, Mark P. Foster, Brandon L. Crowe, Mamuka Kvaratskhelia, Sriram Aiyer
Publikováno v:
Nucleic Acids Research
The importance of understanding the molecular mechanisms of murine leukemia virus (MLV) integration into host chromatin is highlighted by the development of MLV-based vectors for human gene-therapy. We have recently identified BET proteins (Brd2, 3 a
Autor:
Mamuka Kvaratskhelia, Robert Graham, Sonja Hess, Mark P. Foster, Matthew R. Plumb, Jocelyn O. Eidahl, Christopher McKee, Lei Feng, Nikoloz Shkriabai, Michael G. Poirier, Brandon L. Crowe, Robert J. Gorelick, Justin A. North
Publikováno v:
Nucleic Acids Research
Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 interactions with lentiviral integrases are well characterized, but the stru
Autor:
Ross C. Larue, Mamuka Kvaratskhelia, Elizabeth K. Coward, Li Wu, Alison Slaughter, Matthew R. Plumb, Patrick L. Green, Sriram Aiyer, Monica J. Roth, Jacques J. Kessl, Nikoloz Shkriabai, Nirav Malani, Amit Sharma, Frances Male, Frederic D. Bushman
Publikováno v:
Retrovirology
Background The selection of chromosomal targets for retroviral integration varies markedly, tracking with the genus of the retrovirus, suggestive of specific targeting by cellular factors. Gamma-retroviral murine leukemia virus (MLV) DNA integration
Autor:
Elizabeth K. Coward, Nikolozi Shkriabai, Alison Slaughter, Mamuka Kvaratskhelia, Ross C. Larue, Nirav Malani, Frederic D. Bushman, Jacques J. Kessl, Patrick L. Green, Monica J. Roth, Matthew R. Plumb, Li Wu, Amit Sharma, Frances Male, Sriram Aiyer
The selection of chromosomal targets for retroviral integration varies markedly, tracking with the genus of the retrovirus, suggestive of targeting by binding to cellular factors. γ-Retroviral murine leukemia virus (MLV) DNA integration into the hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea1e7fe2f4b07496c157a170818f3e2
https://europepmc.org/articles/PMC3718171/
https://europepmc.org/articles/PMC3718171/