Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Matthew R, Pincus"'
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1144 (2024)
Recent advances in cancer treatment like personalized chemotherapy and immunotherapy are aimed at tumors that meet certain specifications. In this review, we describe a new approach to general cancer treatment, termed peptide-induced poptosis, in whi
Externí odkaz:
https://doaj.org/article/2df602e9301c461080066e667f7f8d4c
Autor:
Anna I. Miller, David Diaz, Bo Lin, Patryk K. Krzesaj, Sarah Ustoyev, Alfred Shim, Eugene J. Fine, Ehsan Sarafraz-Yazdi, Matthew R. Pincus, Richard D. Feinman
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2515 (2023)
The ketone bodies, sodium and lithium salts of acetoacetate (AcAc) and sodium 3-hydroxybutyrate (3-HB; commonly called beta-hydroxybutyrate) have been found to inhibit the proliferation of cancer cells. Previous studies have suggested that lithium it
Externí odkaz:
https://doaj.org/article/b379fc706f9745df8ae1d84fe6abb45d
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 471 (2023)
This is a review of approaches to the design of peptides and small molecules that selectively block the oncogenic RAS-p21 protein in ras-induced cancers. Single amino acid substitutions in this protein, at critical positions such as at Gly 12 and Gln
Externí odkaz:
https://doaj.org/article/456a88ced2f04fffa28cdf096115313f
Autor:
Ehsan Sarafraz-Yazdi, Stephen Mumin, Diana Cheung, Daniel Fridman, Brian Lin, Lawrence Wong, Ramon Rosal, Rebecca Rudolph, Matthew Frenkel, Anusha Thadi, William F. Morano, Wilbur B. Bowne, Matthew R. Pincus, Josef Michl
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 945 (2022)
PNC-27, a 32-residue peptide that contains an HDM-2 binding domain and a cell-penetrating peptide (CPP) leader sequence kills cancer, but not normal, cells by binding to HDM-2 associated with the plasma membrane and induces the formation of pores cau
Externí odkaz:
https://doaj.org/article/42c0ab7d56654ac4b1d38423cc4eef80
Autor:
Matthew R. Pincus, Kristine A Ward, Lauren Lewis, Eve Goldstein, Wilbur B. Bowne, Marian Khalili, Boris Polyak, Martin H. Bluth, Anusha Thadi, Anshu Aggarwal, Shabnam Seydafkan, Michael Styler, Lindsay Steele, Paul M Campbell
Publikováno v:
Anticancer Research. 40:4857-4867
Background/aim Anticancer peptide PNC-27 binds to HDM-2 protein on cancer cell membranes inducing the formation of cytotoxic transmembrane pores. Herein, we investigated HDM-2 membrane expression and the effect of PNC-27 treatment on human non-stem c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3471e9881c61846fa539f6da5e6e49
https://doi.org/10.21873/anticanres.14488
https://doi.org/10.21873/anticanres.14488
Publikováno v:
American Journal of Clinical Pathology. 156:S43-S44
Introduction/Objective The incidence of anal squamous cell carcinoma is increasing in high risk populations. There is no consensus regarding screening for anal squamous cell carcinoma. Anal pap smears are interpreted using the Bethesda System for cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75bf7af74ca9e1f2639cc97648969003
https://doi.org/10.1093/ajcp/aqab191.087
https://doi.org/10.1093/ajcp/aqab191.087
Autor:
Huaien Wang, Nourelhoda Gouda, Andrew E. Lincoln, Noah Moller-Medzon, Angela Chan, Mecca Wright, Nana Ayoluwa, Rauful Hossain, Elmer Gabutan, Miranda McGaskey, Brandon May, Chongfeng Bi, Gil Pagaspas, Gabriella Pollonini, Kelly Holmes, Daniel Neumann, Raychel Lewis, James Lowe, Nusrat Khan, Chante Guy, Nadia Khan, Matthew R. Pincus, Xiao Chen, Jane Kim, Helen Hoxie, Arabia Dodson, Keena Barnes, Candice Gordon, Shanique Jones, Sean Seibel, Elvin Colon, Ana Vasileva, Ethan M. Berke, Robby S. Sikka, Brianna Kelly, James L. Connolly, Meimei Wang, Jenny Libien, Aneeza Asif, Hui-Ting Cheng, Tasnim Chowdhury, Rachelle Mendoza, Prem Premsrirut, Nicholas Gao, Meril Takizawa, Anne L. Wyllie, Michele Esposito
The negative impact of continued school closures during the height of the COVID-19 pandemic warrants the establishment of new cost-effective strategies for surveillance and screening to safely reopen and monitor for potential in-school transmission.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6afe9d36ffb75259b6141ea37389868
https://doi.org/10.1101/2021.02.09.21251464
https://doi.org/10.1101/2021.02.09.21251464
Autor:
William F. Morano, Paul M Campbell, Anusha Thadi, Matthew R. Pincus, Deshka S. Foster, Bo Lin, Eve Goldstein, Wilbur B. Bowne, Elizabeth M. Gleeson, Blake D Babcock, Lindsay Steele, Marian Khalili, Yelena Piazza, Mohammad F. Shaikh
Publikováno v:
Anticancer research. 41(1)
Background/aim We have tested whether the anticancer peptide, PNC-27, that kills cancer cells but not normal cells by binding to cancer cell membrane HDM-2 forming pores, kills CD44+ colon cancer stem cells. Materials and methods Flow cytometry deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819d6792381c4da7d73fb75a45ba49c5
https://pubmed.ncbi.nlm.nih.gov/33419797
https://pubmed.ncbi.nlm.nih.gov/33419797
Autor:
Anusha, Thadi, Elizabeth M, Gleeson, Marian, Khalili, Mohammad F, Shaikh, Eve, Goldstein, William F, Morano, Lynsey M, Daniels, Nikhil, Grandhi, Haley, Glatthorn, Scott D, Richard, Paul M, Campbell, Ehsan, Sarafraz-Yazdi, Matthew R, Pincus, Wilbur B, Bowne
Publikováno v:
Annals of clinical and laboratory science. 50(5)
Patients with epithelial ovarian cancers experience the highest fatality rates among all gynecological malignancies which require development of novel treatment strategies. Tumor cell necrosis was previously reported in a number of cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22837289df64f1ea9b3469b72671ffc3
https://pubmed.ncbi.nlm.nih.gov/33067207
https://pubmed.ncbi.nlm.nih.gov/33067207
Publikováno v:
The protein journal. 39(3)
We have computed the low energy minima for the two endomorphin peptides, N-acetyl-Tyr-Pro-Trp-Phe-NHCH3 (endomorphin 1) and Tyr-Pro-Phe-Phe-NHCH3 (endomorphin 2) in aqueous solution. These peptides block pain without inducing the harmful side effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac1cc11e668c54d492ec3cb89b08ce5
https://pubmed.ncbi.nlm.nih.gov/32449111
https://pubmed.ncbi.nlm.nih.gov/32449111