Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Matthew R, Levengood"'
Autor:
Vivian Trang, Weiping Zeng, Julia H. Cochran, Xinqun Zhang, Serena W. Wo, Maureen Ryan, Melissa M. Dominguez, Peter D. Senter, Jessica K. Simmons, Matthew R. Levengood, Ivan Stone, Roma C. Yumul, Robert P. Lyon
Publikováno v:
Nature Biotechnology. 37:761-765
The use of monoclonal antibodies in cancer therapy is limited by their cross-reactivity to healthy tissue. Tumor targeting has been improved by generating masked antibodies that are selectively activated in the tumor microenvironment, but each such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3ac2163aeb26ce3ffaadf5efd028ae6
https://doi.org/10.1038/s41587-019-0135-x
https://doi.org/10.1038/s41587-019-0135-x
Publikováno v:
Journal of Biological Chemistry. 292:2944-2955
The suborder Corynebacterineae encompasses species like Corynebacterium glutamicum, which has been harnessed for industrial production of amino acids, as well as Corynebacterium diphtheriae and Mycobacterium tuberculosis, which cause devastating huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e6b029dc6e29b8297825fad92564e7
https://doi.org/10.1074/jbc.m116.759340
https://doi.org/10.1074/jbc.m116.759340
Autor:
Vivian H, Trang, Xinqun, Zhang, Roma C, Yumul, Weiping, Zeng, Ivan J, Stone, Serena W, Wo, Melissa M, Dominguez, Julia H, Cochran, Jessica K, Simmons, Maureen C, Ryan, Robert P, Lyon, Peter D, Senter, Matthew R, Levengood
Publikováno v:
Nature biotechnology. 37(7)
The use of monoclonal antibodies in cancer therapy is limited by their cross-reactivity to healthy tissue. Tumor targeting has been improved by generating masked antibodies that are selectively activated in the tumor microenvironment, but each such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a73508dee1b508d11f9e1d4dc32d07d
https://pubmed.ncbi.nlm.nih.gov/31133742
https://pubmed.ncbi.nlm.nih.gov/31133742
Publikováno v:
The Journal of biological chemistry. 292(7)
The suborder Corynebacterineae encompasses species like Corynebacterium glutamicum, which has been harnessed for industrial production of amino acids, as well as Corynebacterium diphtheriae and Mycobacterium tuberculosis, which cause devastating huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::abde0a24be49c15e890c20116af38695
https://pubmed.ncbi.nlm.nih.gov/28039359
https://pubmed.ncbi.nlm.nih.gov/28039359
Autor:
Jamie B. Miyamoto, Timothy S. Lewis, Joshua H. Hunter, Peter D. Senter, Xinqun Zhang, Kim K. Emmerton, Matthew R. Levengood
Publikováno v:
Angewandte Chemie (International Ed. in English)
A strategy for the preparation of homogeneous antibody–drug conjugates (ADCs) containing multiple payloads has been developed. This approach utilizes sequential unmasking of cysteine residues with orthogonal protection to enable site‐specific con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639527dd3582ff445f461a1e2ca7479f
https://pubmed.ncbi.nlm.nih.gov/27966822
https://pubmed.ncbi.nlm.nih.gov/27966822
Autor:
Weiping Zeng, Melissa M. Dominguez, Ivan Stone, Julia H. Cochran, Peter D. Senter, Matthew R. Levengood, Vivian Trang, Xinqun Zhang
Publikováno v:
Cancer Research. 78:750-750
The power of monoclonal antibody therapeutics arises from their remarkable selectivity for a particular antigen. However, antibody therapies can still be limited by serious side effects that result from target-mediated toxicity when the antigen is al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83b6dbe835d48d72cf2fd011ac762ed9
https://doi.org/10.1158/1538-7445.am2018-750
https://doi.org/10.1158/1538-7445.am2018-750
Autor:
Young Ok You, Wilfred A. van der Donk, Aaron K. Knowlton, Matthew R. Levengood, L. A. Furgerson Ihnken
Publikováno v:
ACS Chemical Biology
Methods that introduce posttranslational modifications in a general, mild, and non-sequence-specific manner using biologically produced peptides have great utility for investigation of the functions of these modifications. In this study, the substrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f6d83cc248623c13f4f6397ff85f96
https://doi.org/10.1021/cb800309v
https://doi.org/10.1021/cb800309v
Publikováno v:
ChemBioChem. 10:911-919
Lantibiotics are peptide antimicrobial compounds that are characterized by the thioether-bridged amino acids lanthionine and methyllanthionine. For lacticin 481, these structures are installed in a two-step post-translational modification process by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ff8e6f5fb086d07f181cc18d555606
https://doi.org/10.1002/cbic.200800752
https://doi.org/10.1002/cbic.200800752
Publikováno v:
Cancer Research. 77:982-982
A common theme in treating cancer is the use of combination chemotherapy, where multiple drugs with different mechanisms of action are combined to elicit synergistic activity or overcome differential drug sensitivities. Antibody-drug conjugates (ADCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29145b9c01062021e37b0d81032e77ba
https://doi.org/10.1158/1538-7445.am2017-982
https://doi.org/10.1158/1538-7445.am2017-982
A Processive Carbohydrate Polymerase That Mediates Bifunctional Catalysis Using a Single Active Site
Autor:
John F. May, Rebecca A. Splain, Christopher D. Brown, Laura L. Kiessling, Matthew R. Levengood
Even in the absence of a template, glycosyltransferases can catalyze the synthesis of carbohydrate polymers of specific sequence. The paradigm has been that one enzyme catalyzes the formation of one type of glycosidic linkage, yet certain glycosyltra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c819b7b7789cfdb09fa3cf5fe855f7e
https://europepmc.org/articles/PMC3326345/
https://europepmc.org/articles/PMC3326345/
