Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Matthew R, Hass"'
Autor:
Kenyatta C. M. F. Viel, Sreeja Parameswaran, Omer A. Donmez, Carmy R. Forney, Matthew R. Hass, Cailing Yin, Sydney H. Jones, Hayley K. Prosser, Arame A. Diouf, Olivia E. Gittens, Lee E. Edsall, Xiaoting Chen, Hope Rowden, Katelyn A. Dunn, Rui Guo, Andrew VonHandorf, Merrin Man Long Leong, Kevin Ernst, Kenneth M. Kaufman, Lucinda P. Lawson, Ben Gewurz, Bo Zhao, Leah C. Kottyan, Matthew T. Weirauch
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background There are two major genetic types of Epstein-Barr Virus (EBV): type 1 (EBV-1) and type 2 (EBV-2). EBV functions by manipulating gene expression in host B cells, using virus-encoded gene regulatory proteins including Epstein-Barr N
Externí odkaz:
https://doaj.org/article/155fc47c06e74fd5b11dee66241b344d
Autor:
Matthew R Hass, Daniel Brissette, Sreeja Parameswaran, Mario Pujato, Omer Donmez, Leah C Kottyan, Matthew T Weirauch, Raphael Kopan
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009574 (2021)
Runt-related transcription factor 1 (Runx1) can act as both an activator and a repressor. Here we show that CRISPR-mediated deletion of Runx1 in mouse metanephric mesenchyme-derived mK4 cells results in large-scale genome-wide changes to chromatin ac
Externí odkaz:
https://doaj.org/article/a61e659e34d045a0b33e892800ee2cb9
Autor:
Francis M Kobia, Kristina Preusse, Quanhui Dai, Nicholas Weaver, Matthew R Hass, Praneet Chaturvedi, Sarah J Stein, Warren S Pear, Zhenyu Yuan, Rhett A Kovall, Yi Kuang, Natanel Eafergen, David Sprinzak, Brian Gebelein, Eric W Brunskill, Raphael Kopan
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000850 (2020)
Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for
Externí odkaz:
https://doaj.org/article/56bb8176d92c404f8da9d4b31d6102f3
Autor:
Yi Kuang, Ohad Golan, Kristina Preusse, Brittany Cain, Collin J Christensen, Joseph Salomone, Ian Campbell, FearGod V Okwubido-Williams, Matthew R Hass, Zhenyu Yuan, Nathanel Eafergan, Kenneth H Moberg, Rhett A Kovall, Raphael Kopan, David Sprinzak, Brian Gebelein
Publikováno v:
eLife, Vol 9 (2020)
Notch pathway haploinsufficiency can cause severe developmental syndromes with highly variable penetrance. Currently, we have a limited mechanistic understanding of phenotype variability due to gene dosage. Here, we unexpectedly found that inserting
Externí odkaz:
https://doaj.org/article/d503de51d4de46d4b3e298e0644a7d3d
Autor:
Raphael Kopan, Daniel Brissette, Matthew T. Weirauch, Matthew R. Hass, Sreeja Parameswaran, Leah C. Kottyan, Mario Pujato, Omer Donmez
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 6, p e1009574 (2021)
PLoS Genetics, Vol 17, Iss 6, p e1009574 (2021)
Runt-related transcription factor 1 (Runx1) can act as both an activator and a repressor. Here we show that CRISPR-mediated deletion of Runx1 in mouse metanephric mesenchyme-derived mK4 cells results in large-scale genome-wide changes to chromatin ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052a2bd065af1a8ccaed0b889492a280
https://pubmed.ncbi.nlm.nih.gov/34111109
https://pubmed.ncbi.nlm.nih.gov/34111109
Autor:
Leah C. Kottyan, Mario Pujato, Sreeja Parameswaran, Omer Donmez, Raphael Kopan, Matthew T. Weirauch, Daniel Brisette, Matthew R. Hass
Runt-related transcription factor 1 (Runx1) can act as both an activator and a repressor. Here we show that CRISPR-mediated deletion of Runx1 in an embryonic kidney-derived cell (mK4) results in large-scale genome-wide changes to chromatin accessibil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac310729c5f9d584873c3c5895ac583
https://doi.org/10.1101/2020.09.25.313767
https://doi.org/10.1101/2020.09.25.313767
Autor:
Brian Gebelein, Zhenyu Yuan, Yi Kuang, Raphael Kopan, Matthew R. Hass, FearGod V Okwubido-Williams, Ohad Golan, Kristina Preusse, Joseph Salomone, Collin J Christensen, Brittany Cain, Rhett A. Kovall, David Sprinzak, Ian Campbell, Kenneth H. Moberg, Nathanel Eafergan
Publikováno v:
eLife, Vol 9 (2020)
Notch pathway haploinsufficiency can cause severe developmental syndromes with highly variable penetrance. Currently, we have a limited mechanistic understanding of phenotype variability due to gene dosage. Here, we unexpectedly found that inserting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830b6f447d0e1bd3898e0fdaa1f85633
https://doi.org/10.7554/elife.53659
https://doi.org/10.7554/elife.53659
Autor:
Yi Kuang, Kristina Preusse, Matthew R. Hass, Ohad Golan, Ian Campbell, Zhenyu Yuan, David Sprinzak, Rhett A. Kovall, Raphael Kopan, Brittany Cain, Collin J Christensen, Brian Gebelein, Kenneth H. Moberg, FearGod V Okwubido-Williams, Nathanel Eafergan, Joseph Salomone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d808fd3b59b5e4b091bd358f10b40808
https://doi.org/10.7554/elife.53659.sa2
https://doi.org/10.7554/elife.53659.sa2
Autor:
Raphael Kopan, Brian Gebelein, Francis M. Kobia, Sarah J. Stein, Rhett A. Kovall, Warren S. Pear, Kristina Preusse, Quanhui Dai, Yi Kuang, David Sprinzak, Natanel Eafergen, Eric W. Brunskill, Praneet Chaturvedi, Nicholas Weaver, Matthew R. Hass, Zhenyu Yuan
Publikováno v:
PLoS Biology
PLoS Biology, Vol 18, Iss 10, p e3000850 (2020)
PLoS Biology, Vol 18, Iss 10, p e3000850 (2020)
Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a9475d271e0979f0f791d9d3588804
https://pubmed.ncbi.nlm.nih.gov/33017398
https://pubmed.ncbi.nlm.nih.gov/33017398
Autor:
Chihiro Sato, Mustafa Turkoz, Joshua T Dearborn, David F Wozniak, Raphael Kopan, Matthew R Hass
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48180 (2012)
Previous studies suggest that loss of γ-secretase activity in postnatal mouse brains causes age-dependent memory impairment and neurodegeneration. Due to the diverse array of γ-secretase substrates, it remains to be demonstrated whether loss of cle
Externí odkaz:
https://doaj.org/article/866e48f701074e758bca789c28719da6