Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthew Pratt-Hyatt"'
Publikováno v:
Gene. 556:13-18
Mod5 is the yeast tRNA isopentenyl transferase, an enzyme that is conserved from bacteria to humans. Mod5 is primarily cytoplasmic where it modifies the A37 position of a few tRNAs, and the yeast enzyme has been shown capable of forming heritable, am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2f7b969ab5e47c32a45e09148f813c
https://doi.org/10.1016/j.gene.2014.09.049
https://doi.org/10.1016/j.gene.2014.09.049
Autor:
Kottarappat N. Dileepan, Donald D. Smith, Andrew J. Lickteig, Iván L. Csanaky, James P. Luyendyk, Gregory A. Reed, Rachel Cherian, Karen M. Kassel, Kurt J. Williams, Curtis D. Klaassen, Vineesh V. Raveendran, Colleen A. Flynn, Matthew Pratt-Hyatt
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 307:G219-G228
We examined the effects of two over-the-counter H1-antihistamines on the progression of fatty liver disease in male C57Bl/6 wild-type and apolipoprotein E (ApoE)−/− mice. Mice were fed a high-fat diet (HFD) for 3 mo, together with administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80919f54fd36f3f526222e50ee389ae7
https://doi.org/10.1152/ajpgi.00027.2014
https://doi.org/10.1152/ajpgi.00027.2014
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 151(2)
Activation of Constitutive Androstane Receptor (CAR) protects against bile acid (BA)-induced liver injury. This study was performed to determine the effect of CAR activation on bile flow, BA profile, as well as expression of BA synthesis and transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcdd9e2b5564bd4151ca5094ce2c776
https://pubmed.ncbi.nlm.nih.gov/26984780
https://pubmed.ncbi.nlm.nih.gov/26984780
Autor:
Matthew Pratt-Hyatt, Haoming Zhang, Cesar Kenaan, Erin V. Shea, Hsia Lien Lin, Paul F. Hollenberg
Publikováno v:
Drug Metabolism and Disposition. 41:101-110
Studies in microsomal and reconstituted systems have shown that the presence of one cytochrome P450 isoform can significantly influence the catalytic activity of another isoform. In this study, we assessed whether CYP2E1 could influence the catalytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2a06797eca9a30d2d228a744f839b8
https://doi.org/10.1124/dmd.112.046094
https://doi.org/10.1124/dmd.112.046094
Autor:
Carrie L. Welch, Matthew Pratt-Hyatt, Curtis D. Klaassen, Rebecca A. Haeusler, Domenico Accili
Publikováno v:
Cell Metabolism. 15(1):65-74
SummaryThe association of type 2 diabetes with elevated plasma triglyceride (TG) and very low-density lipoproteins (VLDL), and intrahepatic lipid accumulation represents a pathophysiological enigma and an unmet therapeutic challenge. Here, we uncover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc18ab5eafec8826158133a93d57b9d3
Publikováno v:
Genes & Development. 22:2204-2214
The 274 tRNA genes in Saccharomyces cerevisiae are scattered throughout the linear maps of the 16 chromosomes, but the genes are clustered at the nucleolus when compacted in the nucleus. This clustering is dependent on intact nucleolar organization a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40efc7e2ebe8c89f949a0c76d76e2441
https://doi.org/10.1101/gad.1675908
https://doi.org/10.1101/gad.1675908
Autor:
Jing Lu, Iván L. Csanaky, Anuradha Rao, Paul A. Dawson, Xiaoling Li, Andrew J. Lickteig, Aparna Purushotham, Yingming Zhao, Nevzat Kazgan, Mallikarjuna R. Metukuri, Matthew Pratt–Hyatt, Sangkyu Lee
Publikováno v:
Gastroenterology. 146(4)
Background & Aims Sirtuin 1 (SIRT1), the most conserved mammalian oxidized nicotinamide adenine dinucleotide–dependent protein deacetylase, is an important metabolic sensor in many tissues. However, little is known about its role in the small intes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2c5295573ef72fcca82be85cf02462
https://pubmed.ncbi.nlm.nih.gov/24566103
https://pubmed.ncbi.nlm.nih.gov/24566103
Autor:
Dave A. Pai, Matthew Pratt-Hyatt, Ian McLeod, John R. Yates, Paul D. Good, Anita K. Hopper, David R. Engelke, Glenn G. Wozniak, Rebecca A. Haeusler, Erin L. Miller
Publikováno v:
Proceedings of the National Academy of Sciences. 110
The tRNA gene-mediated (tgm) silencing of RNA polymerase II promoters is dependent on subnuclear clustering of the tRNA genes, but genetic analysis shows that the silencing requires additional mechanisms. We have identified proteins that bind tRNA ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86885c9f3089875cbc23f177b7b06a1
https://doi.org/10.1073/pnas.1219946110
https://doi.org/10.1073/pnas.1219946110
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 41(8)
Aldo-keto reductases (Akrs) are a conserved group of NADPH-dependent oxido-reductase enzymes. This study provides a comprehensive examination of the tissue distribution of the 16 substrate-metabolizing Akrs in mice, their expression during developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f25813c4a203b2bb37b69517021a62
https://pubmed.ncbi.nlm.nih.gov/23660342
https://pubmed.ncbi.nlm.nih.gov/23660342
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 39(12)
The mechanism-based inactivation of human CYP2B6 by tert-butylphenylacetylene (BPA) in the reconstituted system was investigated. The inactivation of CYP2B6 by BPA is time-, concentration-, and NADPH-dependent and exhibits a K(I) of 2.8 μM, a k(inac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbc72d64f74a6f9b5be48d79a57faae
https://pubmed.ncbi.nlm.nih.gov/21930824
https://pubmed.ncbi.nlm.nih.gov/21930824