Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Matthew Plant"'
Publikováno v:
BBA Advances, Vol 1, Iss , Pp 100022- (2021)
The fundamental importance of membrane protein (MP) targets in central biological and cellular events has driven a marked increase in the use of membrane mimetics for exploring these proteins as therapeutic targets. The main challenge associated with
Externí odkaz:
https://doaj.org/article/ec1e472128ac483db74b592db91ec414
Autor:
Karen Rex, Shawn Jeffries, Matthew L Brown, Timothy Carlson, Angela Coxon, Flordeliza Fajardo, Brendon Frank, Darin Gustin, Alexander Kamb, Paul D Kassner, Shyun Li, Yihong Li, Kurt Morgenstern, Matthew Plant, Kim Quon, Astrid Ruefli-Brasse, Joanna Schmidt, Elissa Swearingen, Nigel Walker, Zhulun Wang, J E Vivienne Watson, Dineli Wickramasinghe, Mariwil Wong, Guifen Xu, Holger Wesche
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68328 (2013)
Sphingosine kinases (SPHKs) are enzymes that phosphorylate the lipid sphingosine, leading to the formation of sphingosine-1-phosphate (S1P). In addition to the well established role of extracellular S1P as a mitogen and potent chemoattractant, SPHK a
Externí odkaz:
https://doaj.org/article/dfda1f39979a456d9edd17f32579cba1
Autor:
Ryan P. Wurz, Liping H. Pettus, Bradley Henkle, Lisa Sherman, Matthew Plant, Kent Miner, Helen J. McBride, Lu Min Wong, Christiaan J.M. Saris, Matthew R. Lee, Samer Chmait, Christopher Mohr, Faye Hsieh, Andrew S. Tasker
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(5)
A novel class of pyrazolopyridazine p38alpha mitogen-activated protein kinase (MAPK) inhibitors is disclosed. A structure activity relationship (SAR) investigation was conducted driven by the ability of these compounds to inhibit the p38alpha enzyme,
Autor:
Holger Wesche, Matthew L. Brown, Timothy J. Carlson, Angela Coxon, Brendon Frank, Darin J. Gustin, Shawn Jeffries, Shyun Li, Yihong Li, Kurt Morgenstern, Matthew Plant, Karen Rex, Joanna Schmidt, Shanling Shen, Nigel Walker, Dineli Wickramasinghe, Guifen Xu
Publikováno v:
Cancer Research. 73:LB-39
Sphingosine kinase activity is not required for tumor cell viability Holger Wesche, Matthew L. Brown, Timothy J. Carlson, Angela Coxon, Brendon Frank, Darin J. Gustin, Shawn Jeffries, Shyun Li, Yihong Li, Kurt Morgenstern, Matthew Plant, Karen Rex, J
Autor:
Essa Hu, Andrew Tasker, Ryan D. White, Roxanne K. Kunz, Jason Human, Ning Chen, Roland Bürli, Randall Hungate, Perry Novak, Andrea Itano, Xuxia Zhang, Violeta Yu, Yen Nguyen, Yanyan Tudor, Matthew Plant, Shaun Flynn, Yang Xu, Kristin L. Meagher, Douglas A. Whittington, Gordon Y. Ng
Publikováno v:
Journal of Medicinal Chemistry; May2008, Vol. 51 Issue 11, p3065-3068, 4p
Autor:
Violeta Yu, Yanyan Tudor, Clarence Hale, Matthew Plant, Ki Won Kim, Minghan Wang, Yen Nguyen, Tisha San Miguel, Michelle Chen, Rebecca Nybo, Jamie Baumgartner, Robert J.M. Kurzeja, David Powers
Publikováno v:
Assay & Drug Development Technologies; Feb2007, Vol. 5 Issue 1, p105-116, 12p