Dysregulation of distal cholesterol biosynthesis in association with relapse and advanced disease in CHC genotype 2 and 3 treated with sofosbuvir and ribavirin

Autor: Zobair M. Younossi, Matthew Paulson, Paul J. Clark, Maria Stepanova, Francesco Negro, Qinghua Song, John G. McHutchison, Luisa M. Stamm, Michael Estep, Diana M. Brainard, G. Mani Subramanian, Sharon L. Hunt, Keyur Patel

Publikováno v: Journal of Hepatology, Vol. 64, No 1 (2016) pp. 29-36

Hepatitis C virus (HCV) modulates host lipid metabolism for its replication and lifecycle. Our aims were to assess changes in the serum lipid and distal (post-squalene) cholesterol biosynthesis metabolite profile of HCV genotypes (GT) 2 and 3 patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034340cf45c2254d4341f904b36456c1
https://doi.org/10.1016/j.jhep.2015.08.027

Selection of Clinically Relevant Protease Inhibitor-Resistant Viruses Using the Genotype 2a Hepatitis C Virus Infection System

Autor: William E. Delaney, Maria Pokrovskii, Weidong Zhong, Katie Chan, Amy Corsa, Guofeng Cheng, Matthew Paulson, Gina Bahador, Huiling Yang

Publikováno v: Antimicrobial Agents and Chemotherapy. 55:2197-2205

Treatment of patients infected with hepatitis C virus (HCV) with direct acting antivirals can lead to the emergence of drug-resistant variants that may pose a long-term threat to viral eradication. HCV replicons have been used to select resistance mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9554dffa75f8dde5159f4cd354b41ed5
https://doi.org/10.1128/aac.01382-10

Substituted imidazopyridines as potent inhibitors of HCV replication☆

Autor: David A. Oare, I-hung Shih, Laura S. Lehman, Erik De Clercq, Eric Mabery, Steven S. Bondy, Weidong Zhong, Inge Vliegen, Matthew Paulson, Johan Neyts, Gerhard Pürstinger, Hans Reiser, Jan Paeshuyse, Nina Boddeker, Tine De Burghgraeve, William A. Lee

Publikováno v: Journal of Hepatology

Background/Aims Following lead optimization, a set of substituted imidazopyridines was identified as potent and selective inhibitors of in vitro HCV replication. The particular characteristics of one of the most potent compounds in this series (5-[[3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034b0a9d32ab3e902fed4fe6a8554f20
http://europepmc.org/articles/PMC7114863

Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity

Autor: Michelle Holko, Bryan R.G. Williams, Charles M. Rice, Isabelle Marié, Hao-Ming Chang, David E. Levy, Matthew Paulson

Publikováno v: Proceedings of the National Academy of Sciences. 101:9578-9583

Histone deacetylase (HDAC) activity, commonly correlated with transcriptional repression, was essential for transcriptional induction of IFN-stimulated genes (ISG). Inhibition of HDAC function led to global impairment of ISG expression, with little e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672b3243317036859464ec12d7fb9ad2
https://doi.org/10.1073/pnas.0400567101

Interferon γ-induced protein10 kinetics in treatment-naive versus treatment-experienced patients receiving interferon-free therapy for hepatitis C virus infection: Implications for the innate immune response

Autor: Jennifer C. Lin, Maribel Rodriguez-Torres, François Habersetzer, Yanni Zhu, Mark S. Sulkowski, Robert T. Schooley, David L. Wyles, Gangadharan Mani Subramanian, Eric Lawitz, John G. McHutchison, Nezam H. Afdhal, Matthew Paulson

Publikováno v: Lin, JC; Habersetzer, F; Rodriguez-Torres, M; Afdhal, N; Lawitz, EJ; Paulson, MS; et al.(2014). Interferon γ-induced protein10 kinetics in treatment-naive versus treatment-experienced patients receiving interferon-free therapy for hepatitis C virus infection: Implications for the innate immune response. Journal of Infectious Diseases, 210(12), 1881-1885. doi: 10.1093/infdis/jiu325. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/27x3x8q7

© The Author 2014. We measured interferon γ-induced protein 10 (IP-10) levels in 428 patients at baseline, week 1, and week 2 of all-oral treatment for hepatitis C virus (HCV) infection. An increased baseline IP-10 level was associated with a T all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c106b183343b181e3034133c16371c
http://www.escholarship.org/uc/item/27x3x8q7