Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Matthew P. Strout"'
Publikováno v:
FEBS Open Bio, Vol 10, Iss 9, Pp 1782-1792 (2020)
Activation‐induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination of immunoglobulin genes in B cells, whereas off‐targeted AID activity contributes to oncogenic mutations and chromosomal translocations ass
Externí odkaz:
https://doaj.org/article/7179933ddb07459a8111ceabc93ffbae
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 10, Iss 9, Pp 1782-1792 (2020)
FEBS Open Bio, Vol 10, Iss 9, Pp 1782-1792 (2020)
Here, we develop a high‐fidelity differential DNA denaturation PCR approach and investigate whether activation‐induced cytidine deaminase (AID) can target mitochondrial DNA (mtDNA) in vitro. We demonstrate AID targeting of mtDNA is a rare event.
Publikováno v:
Blood. 127:102-112
Somatic hypermutation and class-switch recombination of the immunoglobulin (Ig) genes occur in germinal center (GC) B cells and are initiated through deamination of cytidine to uracil by activation-induced cytidine deaminase (AID). Resulting uracil-g
Autor:
Hailong Meng, Peining Li, Larissa Lozovatsky, Steven H. Kleinstein, S. David Hudnall, Matthew P. Strout
Publikováno v:
Leukemialymphoma. 57(12)
Genetic analysis of classical Hodgkin lymphoma (cHL) has been hampered by the paucity of Hodgkin cells in biopsies and their poor growth in vitro. However, a wealth of information has been obtained from cHL cell lines. Here we report results of whole
Autor:
Till Strowig, David G. Schatz, Lin Zhang, Ellice Wong, Richard A. Flavell, Kavita M. Dhodapkar, Matthew P. Strout, Srinivas V. Koduru, Madhav V. Dhodapkar, Ranjini K. Sundaram
Publikováno v:
Blood. 119:2302-2309
Tumor microenvironment (TME) is commonly implicated in regulating the growth of tumors, but whether it can directly alter the genetics of tumors is not known. Genomic instability and dendritic cell (DC) infiltration are common features of several can
Autor:
Adrienne M. Dorrance, Laura J. Rush, Li Yu, Susan P. Whitman, Michael Weinstein, Weifeng Yuan, Amy K. Ferketich, Matthew P. Strout, Lan Feng, Brian Becknell, Martin Guimond, Guido Marcucci, Michael A. Caligiuri, Tatsuya Nakamura, Gustavo Leone, Shujun Liu, Lizhao Wu, Kristy J. Arnoczky
Publikováno v:
Journal of Clinical Investigation. 116:2707-2716
We previously identified a rearrangement of mixed-lineage leukemia (MLL) gene (also known as ALL-1, HRX, and HTRX1), consisting of an in-frame partial tandem duplication (PTD) of exons 5 through 11 in the absence of a partner gene, occurring in appro
Autor:
Clara D. Bloomfield, Marko I. Klisovic, Li Yu, Rebecca B. Klisovic, Guido Marcucci, Chunhui Liu, Laura J. Rush, Kati Maharry, Adrienne M. Dorrance, Martin Guimond, Shujun Liu, Michael A. Caligiuri, Susan P. Whitman, Brian Becknell, Tamara Vukosavljevic, Christoph Plass, Matthew P. Strout
Publikováno v:
Blood. 106:345-352
MLL (ALL-1) chimeric fusions and MLL partial tandem duplications (PTD) may have mechanistically distinct contributions to leukemogenesis. Acute myeloid leukemia (AML) blasts with the t(9;11)(p22; q23) express MLL-AF9 and MLL wild-type (WT) transcript
Autor:
Tapani Ruutu, Matthew P. Strout, Maria Luisa Veronese, Karl S. Theil, Ralf Krahe, Clara D. Bloomfield, Carlo M. Croce, Sakari Knuutila, Michael A. Caligiuri, Brian Becknell, Peter J. Kourlas
Publikováno v:
Proceedings of the National Academy of Sciences. 97:2145-2150
We have identified a gene at 11q23, telomeric to MLL , that encodes a guanine nucleotide exchange factor (GEF). This gene is transcribed into a 9.5-kb mRNA containing a 4.6-kb ORF. By Northern analysis, it was found to be expressed in all human tissu
Autor:
Matthew P. Strout, David G. Schatz
Publikováno v:
Cancer Cell. 16(3):174-176
Very little is known about how acquired oncogenic mutations arise. In this issue of Cancer Cell, Klemm and colleagues present evidence supporting a role for the antibody diversification enzyme activation-induced deaminase (AID) in the generation of m
Autor:
Clara D. Bloomfield, Wael El-Rifai, Erkki Elonen, William A. Held, Donn C. Young, Christoph Plass, Feng Yu, Sakari Knuutila, Guido Marcucci, Li Yu, Matthew P. Strout, Michael A. Caligiuri
Publikováno v:
Oncogene. 18:3159-3165
There is substantial evidence to suggest that aberrant DNA methylation in the regulatory regions of expressed genes may play a role in hematologic malignancy. In the current report, the Restriction Landmark Genomic Scanning (RLGS) method was used to